Determination of Serum Zinc and Phosphorus Levels in Patients with Hypothyroidism

Abstract

BackgroundVarious studies reported that serum zinc (Zn) and phosphorus (P) levels altered in patients with hypothyroidism and vice versa, but results were found inconsistent. AimIt was aimed to nd the association between serum Zn and P in patients with hypothyroidism. Material and MethodIn this case-control study, a total of 100 subjects (50 newly diagnosed patients of hypothyroidism and 50 controls) were enrolled aged between 25 and 60 years. Biochemical parameters such as thyroid pro le, serum Zn, and P were estimated in each subject. A p < 0.05 was considered statistically signi cant. ResultThe mean level of body mass index (BMI), thyroid-stimulating hormone (TSH), and serum P was found signi cantly elevated in cases compared to controls (p < 0.001). However, the mean level of triiodothyronine (T3), thyroxine (T4), and serum Zn was found signi cantly reduced in cases compared to controls (p < 0.001). The serum Zn has shown a signi cant negative correlation with T3 and BMI among cases (r= -0.313 p < 0.05, r= -0.338 p < 0.05, respectively). However, Serum P has shown a signi cant positive correlation with TSH and BMI among cases (r = 0.310 p < 0.05, r = 0.449 p < 0.01, respectively).Regression analysis indicated that serum Zn signi cantly predicted hypothyroidism (p < 0.00). Similarly, Serum P signi cantly predicted hypothyroidism (p < 0.007). ConclusionResults showed that serum Zn levels were signi cantly reduced and serum P levels were signi cantly elevated in cases compared to controls. The serum Zn and serum P both may act as predictors for hypothyroidism and its complications.