Determination of Seventeen Pesticide Residues in Agricultural Products by LC/MS.

Okihashi, Masahiro; Kitagawa, Yoko; Akutsu, Kazuhiko; Obana, Hirotaka; Hori, Shinjiro

doi:10.3358/shokueishi.43.389

Cited by 11 publications

(4 citation statements)

References 13 publications

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“…However, other methods monitored both isomers, e.g. phosphamidon and chlorfenvinphos by GC–MS,9 mevinphos by GC10 and HPLC–APcI–MS11 and dimethomorph by GC–MS,12 LC–MS13 and LC–MS/MS 8, 14, 15. The individual isomers of those pesticides were not separately quantified in any of these papers although they were sometimes well separated.…”

Section: Introductionmentioning

confidence: 99%

Different responses of E:Z‐isomers of pesticides in liquid chromatography–electrospray ionization–mass spectrometry

Mayer-Helm¹,

Hofbauer²,

Pani³

2010

J. Mass Spectrom.

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The mass spectrometric behavior of four pairs of stereoisomers was investigated by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). The E- and Z-isomers of the pesticides chlorfenvinphos, dimethomorph, mevinphos and phosphamidon-each with one double bond-were chosen for this study. The MS response of the individual isomers was investigated by infusing the isomers individually into the MS or after the separation of isomer mixtures via high-performance liquid chromatography (HPLC). In the case of dimethomorph, the same MS response was found for the two isomers. In contrast to that, the individual isomers of chlorfenvinphos, mevinphos and phosphamidon showed different MS response both in the single ion monitoring (SIM) mode in single quadrupole MS and multiple reaction monitoring (MRM) mode in tandem MS. The MS response of the isomers partly depends on (1) the declustering potential of the precursor ion in the SIM mode, (2) the selected transition and (3) the collision energy in the MRM mode. Consequently, quantification by summation of the peak areas of the isomers is inaccurate due to over- or underestimating of one of the stereoisomers. Accurate quantitative results can only be achieved when the compound-specific MS parameters are separately determined for each isomer. This can be done by using pure isomers or by the determination of the MS parameters after HPLC separation and the measurement of the actual isomer ratio with an independent technique.

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Section: Introductionmentioning

confidence: 99%

Different responses of E:Z‐isomers of pesticides in liquid chromatography–electrospray ionization–mass spectrometry

Mayer-Helm¹,

Hofbauer²,

Pani³

2010

J. Mass Spectrom.

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“…HPLC has gained more applications for the determination of many pollutants. As BU insecticides are concerned, there also have some methods such as SPE‐LC–ESI‐MS , HPLC with atmospheric‐pressure chemical ionization MS (HPLC‐APCI‐MS) , HPLC–MS with both ESI and APCI techniques , HPLC–MS/MS with pressurized‐liquid extraction preconcentration , and photochemical‐spectrofluorimetric methods . In order to obtain high sensitivity, the derivatization step is also often used when a conventional HPLC with fluorescence detection is used.…”

Section: Introductionmentioning

confidence: 99%

Dispersive liquid-phase microextraction in combination with HPLC for the enrichment and rapid determination of benzoylurea pesticides in environmental water samples

2013

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Benzoylurea (BU) insecticides have contributed greatly to the output of crops. Their residue in the environment put serious threats on human health and environmental safety. In this study, we have established a new, rapid, and reliable method for the monitoring of typical BU insecticides such as diflubenzuron, flufenoxuron, triflumuron, and chlorfluazuron with dispersive liquid-liquid microextraction prior to HPLC. Chlorobenzene and ethanol were employed as the extraction solvent and disperser solvent, respectively. The possible parameters which would influence the extraction efficiency such as the kinds and volumes of extraction and disperser solvents, extraction time, sample pH, centrifuging time, and salting-out effect were optimized in detail. Under the optimal conditions, the linear range of proposed method was in the range of 1.0-70 μg/L. The detection limits varied from 0.24 to 0.82 μg/L and the precision of the method was <6.5% (RSD, n = 6). The proposed method was validated with real water samples and satisfactory spiked recoveries were achieved. All these results indicate that the proposed method is a low cost, easy to operate, efficient, and sensitive method for the analysis of BU insecticides in water samples.

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“…Many methods have been reported for the analysis of BU insecticides, such as solid‐phase microextraction (SPME) coupled with GC‐MS (SPME‐GC‐MS) 5, SPE prior to HPLC with ESI‐MS (SPE‐LC‐ESI‐MS) 6, photochemical‐spectrofluorimetric method 7 HPLC with atmospheric pressure chemical ionization‐MS 8 and HPLC‐MS with both ESI and atmospheric pressure chemical ionization techniques 9.…”

Section: Introductionmentioning

confidence: 99%

Combination of ultrasound‐assisted ionic liquid dispersive liquid‐phase microextraction and high performance liquid chromatography for the sensitive determination of benzoylureas pesticides in environmental water samples

Zhou

Zhang

2010

J of Separation Science

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This paper describes a new method for rapid and sensitive determination of diflubenzuron, flufenoxuron, triflumuron and chlorfluazuron in water samples by ultrasound-assisted ionic liquid dispersive liquid-phase microextraction in combination with HPLC. Ionic liquid 1-hexyl-3-methylimidazolium hexafluorophosphate ([C(6)MIM][PF(6)]) was used as the extraction solvent for the enrichment of four benzoylurea (BU) pesticides. Factors such as volume of [C(6)MIM][PF(6)], sonication time, sample pH, extraction time, centrifuging time and salting-out effect were systematically investigated. Under the optimum conditions, an excellent linear relationship was achieved in the range of 1.0-100 μg/L. The detection limits varied from 0.21 to 0.45 μg/L and the precision of the method was below 6.9% (RSD, n=6). The proposed method was successfully applied for the determination of these BU pesticides in water samples and excellent spiked recoveries were achieved. All these results demonstrated that this procedure provided a new simple, rapid, easy to operate, efficient and sensitive method for the analysis of BU pesticides in aqueous samples.

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Determination of Seventeen Pesticide Residues in Agricultural Products by LC/MS.

Cited by 11 publications

References 13 publications

Different responses of E:Z‐isomers of pesticides in liquid chromatography–electrospray ionization–mass spectrometry

Different responses of E:Z‐isomers of pesticides in liquid chromatography–electrospray ionization–mass spectrometry

Dispersive liquid-phase microextraction in combination with HPLC for the enrichment and rapid determination of benzoylurea pesticides in environmental water samples

Combination of ultrasound‐assisted ionic liquid dispersive liquid‐phase microextraction and high performance liquid chromatography for the sensitive determination of benzoylureas pesticides in environmental water samples

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