Determination of Sildenafil, Tadalafil, and Vardenafil in Tablets and Adulterated Herbal Products by ESI‐MS‐MS

Abdel-Hamid, M. E.

doi:10.1080/10826070500479393

Cited by 30 publications

(9 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mass spectrum acquired from a tablet containing tadalafil is shown in Figure 2(d) . Peaks corresponding to tadalafil are found at m/z 268 and 412, corresponding to a tadalafil fragment ion and the molecular ion of tadalafil cationized on sodium [ 41 , 44 , 45 ]. The signal intensity of tadalafil in Cialis-type tablets was lower than the other APIs analyzed.…”

Section: Resultsmentioning

confidence: 99%

Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS

Cardoso-Palacios

Lanekoff

2016

Journal of Analytical Methods in Chemistry

View full text Add to dashboard Cite

Counterfeit pharmaceutical drugs imply an increasing threat to the global public health. It is necessary to have systems to control the products that reach the market and to detect falsified medicines. In this work, molecules in several pharmaceutical tablets were directly analyzed using nanospray desorption electrospray ionization mass spectrometry (nano-DESI MS). Nano-DESI is an ambient surface sampling technique which enables sampling of molecules directly from the surface of the tablets without any sample pretreatment. Both the active pharmaceutical ingredients (APIs) and some excipients were detected in all analyzed tablets. Principal component analysis was used to analyze mass spectral features from different tablets showing strong clustering between tablets with different APIs. The obtained results suggest nano-DESI MS as future tool for forensic analysis to discern APIs present in unknown tablet samples.

show abstract

Section: Resultsmentioning

confidence: 99%

Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS

Cardoso-Palacios

Lanekoff

2016

Journal of Analytical Methods in Chemistry

View full text Add to dashboard Cite

show abstract

“…Estimation of these drugs combination with other drugs or alone has been reported. Derivative UV methods for tadalafil in pharmaceutical dosage form [9] and other methods like stability indicating HPLC [10] HPTLC [11], spectrofluorimetry [12], Human serum in HPLC [13], capillary electrophoresis [14], with other combinations [15,16], Estimation of dapoxetine by UV [17], related Impurities in HPLC [18], rat plasma in UPLC/MS [19] and combined with other drugs [20][21] has been reported. Therefore, the aim of the present study for developing simple, rapid, economical and effective method for the simultaneous analysis of tadalafil and dapoxetine applied with DOE and CCD estimation of the developed method.…”

Section: Introductionmentioning

confidence: 99%

Chemometric Access for RP-HPLC Simultaneous Estimation of Tadalafil and Dapoxetine Applying Response Surface Methodology

Jayaseelan¹,

Kannappan

Ganesan³

2021

JPRI

View full text Add to dashboard Cite

Aims: A RP-HPLC method was developed and validated for simultaneous estimation of Tadalafil and Dapoxetine applying statistical experimental design. Methodology: Multivariate optimization of the experimental conditions of RP-HPLC method was using Design of experiments. Independent three factors like phosphate buffer pH, mobile phase composition and flow rate were applied to design mathematical models. To study the response surface methodology by using Central composite design (CCD). In depth the effects of these independent factors was studied using CCD. Simultaneously optimize the retention time and resolution of the analytes was applying Desirability function. Results: The predicted and optimized data from contour picture containing phosphate buffer (pH 3.4) and acetonitrile in the ratio of 40:60%v/v respectively. Flow rate was found to be 0.8 ml/min. Baseline separation of both analytes with run time of less than 10.0 min and good resolution were achieved using these optimum conditions. Conclusion: Method was validated according to ICH guidelines by using optimized assay conditions. Therefore, the reports distinctly indicated that Quality by design access could be satisfactorily used to optimize RP-HPLC method for simultaneous estimation of Tadalafil and Dapoxetine.

show abstract

“…The most frequently used method for determination of SC is high performance liquid chromatography [5][6][7]. Other reported methods for confirmation of SC in pharmaceutical preparations or biological fluids are optical methods such as UV-VIS spectrophotometric methods [8], NMR spectroscopy [9] or Electrospray tandem mass spectrometry (ESI-MS-Ms) spectrophotometry [10] and electroanalytical methods [11][12][13][14][15]. Among electrochemical methods different electrodes and voltammetric techniques were used.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical behavior of sildenafil citrate at gold and cystein modified gold electrode in acid solution

Lović

Trišović

Antanasijević

et al. 2018

J. Electrochem. Sci. Eng.

View full text Add to dashboard Cite

Electrochemical behavior of sildenafil citrate (SC) at gold and cystein (Cys) modified gold electrode (Au/Cys) in 0.1 M H2SO4 was investigated by cyclic voltammetry (CV) and by square wave voltammetry (SWV). Effect of scan rate on the CVs of SC standard was performed in order to examine the mode of transport and irreversibility of process. SC as standard is determined by SWV in acid solution at Au electrode in a range: 10-3, 10-2, 0.1, 0.5, 1 μM and on Au/Cys in a range: 10-3, 10-2, 0.05, 0.1 μM. The presence of Cys causes two-time larger peak currents and shifting of the incipient potential of the SC oxidation to 0.1 V in negative direction. In investigated range of concentration of SC standard in acid solution on modified and unmodified Au electrodes SWV method have excellent linear regression coefficient with value 0.997 promoting SWV for reliable determination of SC.

show abstract

Determination of Sildenafil, Tadalafil, and Vardenafil in Tablets and Adulterated Herbal Products by ESI‐MS‐MS

Cited by 30 publications

References 8 publications

Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS

Direct Analysis of Pharmaceutical Drugs Using Nano-DESI MS

Chemometric Access for RP-HPLC Simultaneous Estimation of Tadalafil and Dapoxetine Applying Response Surface Methodology

Electrochemical behavior of sildenafil citrate at gold and cystein modified gold electrode in acid solution

Contact Info

Product

Resources

About