Determination of single-kidney glomerular filtration rate (GFR) with CT urography versus renal dynamic imaging Gates method

You, Shan; Ma, XianWu; Zhang, Changzhu; Li, Qiang; Shi, Wenwei; Zhang, Jing; Yuan, Xiaoyang

doi:10.1007/s00330-017-5061-z

Cited by 19 publications

(11 citation statements)

References 29 publications

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“…Kwon et al, reported that unilateral GFR measured by contrast enhanced CT was reproducible and it agreed well with the iothalamate clearance [22]. An additional article by You et al reported that, with a renal dynamic image as the reference, the unilateral renal GFR measured by CT revealed a well and significant correlation [23]. We have found similar results in the current study, especially for patients with modified eGFR over 60 mL/min.…”

Section: Discussionsupporting

confidence: 88%

“…It measures objective renal depth while also providing information of renal location and morphology, and, thus, it helps to raise the accuracy when evaluating the GFR. The multidetector CT had been used to measure unilateral renal GFR [22,23]. Kwon et al, reported that unilateral GFR measured by contrast enhanced CT was reproducible and it agreed well with the iothalamate clearance [22].…”

Section: Discussionmentioning

confidence: 98%

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Clinical Comparison of the Glomerular Filtration Rate Calculated from Different Renal Depths and Formulae

Hsu

Chang

2022

Applied Sciences

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A camera-based method using Technetium-99m diethylenetriaminepentaacetic acid (Tc-99m DTPA) is commonly used to calculate glomerular filtration rate (GFR), especially, as it can easily calculate split renal function. Renal depth is the main factor affecting the measurement of GFR accuracy. This study aimed to compare the difference of renal depths between three formulae and a CT scan, and, additionally, to calculate the GFRs by four methods. We retrospectively reviewed the medical records of patients receiving a renal dynamic scan. All patients underwent a laboratory test within one month, and a computed tomography (CT) scan within two months, before or after the renal dynamic scan. The GFRs were calculated by employing a renal dynamic scan using renal depth measured in three formulae (Tonnesen’s, Itoh K’s, and Taylor’s), and a CT scan. The renal depths measured by the above four methods were compared, and the GFRs were compared to the modified estimated GFR (eGFR). Fifty-one patients were enrolled in the study. The mean modified eGFR was 60.5 ± 42.7 mL/min. The mean GFRs calculated by three formulae and CT were 45.3 ± 23.3, 54.7 ± 27.5, 56.5 ± 26.3, and 63.7 ± 30.0, respectively. All of them correlated well with the modified eGFR (r = 0.87, 0.87, 0.87, and 0.84, respectively). The Bland–Altman plot revealed good consistency between the calculated GFR by Tonnesen’s and the modified eGFR. The renal depths measured using the three formulae were smaller than those measured using the CT scan, and the right renal depth was always larger than the left. In patients with modified eGFR > 60 mL/min, the GFR calculated by CT was the closest to the modified eGFR. The Renal depth measured by CT scan is deeper than that using formula, and it influences the GFR calculated by Gate’s method. The GFR calculated by CT is more closely related to modified eGFR when modified eGFR > 60 mL/min.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 98%

Clinical Comparison of the Glomerular Filtration Rate Calculated from Different Renal Depths and Formulae

Hsu

Chang

2022

Applied Sciences

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“…Therefore, the product of kidney volume and CT enhancement value may be used for evaluating kidney function. 36 Hence, spiral CT is a reliable tool to determine whether the contrast agent is filtered by the kidney. Renal blood perfusion and renal filtration effect the CT enhancement at different stages, and have different effects on renal CT value.…”

Section: Imaging Methodsmentioning

confidence: 99%

“…Renal blood perfusion and renal filtration effect the CT enhancement at different stages, and have different effects on renal CT value. 35 , 36 Therefore, contrast media can cause renal injury, which limits the application of enhanced CT.. The accuracy of kidney function by the CT enhancement scan remains to be improved.…”

Section: Imaging Methodsmentioning

confidence: 99%

Present Situation and Research Progress of Kidney Function Recoverability Evaluation of Acute Kidney Injury Patient

Yao¹,

Gao²

2021

IJGM

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Acute kidney injury (AKI) is a critical illness in clinic. The guideline recommendation of kidney disease for improving global outcomes regards urine volume and creatinine as standards to evaluate kidney functions. However, urine volume and creatinine have a certain delay for kidney function evaluation, and these would be interfered by many factors. Whether the renal function of AKI patients can recover is very important, which affects the quality of life of patients. Therefore, the present study reviews the application situation and research progress of the recoverability evaluation of AKI patient kidney function from three aspects: conventional indexes, biomarkers, and imaging methods of kidney function.

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“…[1] Glomerular filtration rate (GFR) is the most direct indicator which can reflect renal filtering function, and it is also one of the most sensitive indicators which are used to evaluate renal function. [2] However, GFR can be only acquired indirectly by calculating the clearance rate of some markers instead of being measured directly. Inulin clearance rate is a generallyacknowledged golden standard in GFR measurement, but it is not suitable to be popularized in clinical practice due to its complicated operation and time waste.…”

Section: Introductionmentioning

confidence: 99%

Comparison of clinical value of dynamic contrast-enhanced MRI and SPECT renal dynamic imaging of GFR measurement in the evaluation of renal function in renal transplantation

Hong

Liu

Yunhe

2019

DCC

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Objective: To compare the clinical value of dynamic contrast-enhanced MRI (DCE-MRI) and single-photon emission computed tomography (SPECT) renal dynamic imaging in the measurement of glomerular filtration rate (GFR) in the evaluation of renal function in renal transplantation.Methods: A total of 70 recipients who underwent renal transplantation in Baogang Hospital of Inner Mongolia from April of 2015 to April of 2018 were selected as research objects. GFR was measured in renal transplant recipients by use of DCE-MRI and SPECT (GFR-MRI and GFR-SPECT respectively), and was compared with creatinine clearance rate (Ccr). The safety of contrast media was evaluated in DCE-MRI detection.Results: The bias of GFR-MRI against Ccr value was higher than that of GFR-SPECT against Ccr value, with 30% and 50% accuracy of GFR-MRI higher than that of GFR-SPECT, and the difference was statistically significant (p < .05). Pearson correlation analysis showed that GFR-MRI and GFR-SPECT values were positively correlated to Ccr (p < .05), and the correlation coefficient of GFR-MRI and Ccr was higher than that of GFR-SPECT and Ccr, with the difference statistically significant (p < .05). By Bland-Altman analysis, 95% confidence interval of GFR-SPECT was 95.49 ml/(min·1.73 m2), and 95% confidence interval of GFR-MRI was 62.35 ml/(min·1.73m2), which was much narrower. Only 2 cases of patients developed mild rash among 70 cases of patients, and recovered spontaneously without any treatment.Conclusions: Compared with SPECT, the bias of GFR measured by DCE-MRI against Ccr is much greater. However, DCE-MRI has a higher accuracy, correlation and consistency in comparison with Ccr, and it has a narrower confidence interval. DCE-MRI can more accurately evaluate renal function in renal transplantation by measuring GFR, and it has a high safety.

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Determination of single-kidney glomerular filtration rate (GFR) with CT urography versus renal dynamic imaging Gates method

Abstract: • A new CT method can assess split renal function • Only using images from CT urography and the value of haematocrit • A one-stop-shop CT technique without additional radiation dose.

Cited by 19 publications

References 29 publications

Clinical Comparison of the Glomerular Filtration Rate Calculated from Different Renal Depths and Formulae

Clinical Comparison of the Glomerular Filtration Rate Calculated from Different Renal Depths and Formulae

Present Situation and Research Progress of Kidney Function Recoverability Evaluation of Acute Kidney Injury Patient

Comparison of clinical value of dynamic contrast-enhanced MRI and SPECT renal dynamic imaging of GFR measurement in the evaluation of renal function in renal transplantation

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