Determination of solubility of Aprepitant (an antiemetic drug for chemotherapy) in supercritical carbon dioxide: Empirical and thermodynamic models

Sodeifian, Gholamhossein; Ardestani, Nedasadat Saadati

doi:10.1016/j.supflu.2017.05.019

Cited by 106 publications

(37 citation statements)

References 37 publications

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“…In our previous study, the reliability of the solubility setup was evaluated by determining the solubility of naphthalene and alpha-tocopherol in SC-CO 2 at different pressures and temperatures and comparing them with the corresponding data in the literature 60 . In general, the authors systematically check and calibrate the device before testing naphthalene and alpha-tocopherol solubilities in SC-CO 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Figure 2 a presents a pressure range of 19–20 MPa that was considered as the crossover pressure area for KTZ in the binary system. In general, several studies demonstrated that the solute vapor pressure and SC-CO 2 density are the major parameters below and top of the crossover area 26 , 60 – 63 . Yamini and Moradi 1 measured KTZ solubility in SC-CO 2 at 12.2–35.5 MPa and 308–348 K considering the absorbance at (220 nm).…”

Section: Resultsmentioning

confidence: 99%

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Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations

Sodeifian

Sajadian

Razmimanesh

et al. 2021

Sci Rep

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One of the main steps in choosing the drug nanoparticle production processes by supercritical carbon dioxide (SC-CO2) is determining the solubility of the solid solute. For this purpose, the solubility of Ketoconazole (KTZ) in the SC-CO2, binary system, as well as in the SC-CO2-menthol (cosolvent), ternary system, was measured at 308–338 K and 12–30 MPa using the static analysis method. The KTZ solubility in the SC-CO2 ranged between 0.20 × 10–6 and 8.02 × 10–5, while drug solubility in the SC-CO2 with cosolvent varied from 1.2 × 10–5 to 1.96 × 10–4. This difference indicated the significant effect of menthol cosolvent on KTZ solubility in the SC-CO2. Moreover, KTZ solubilities in the two systems were correlated by several empirical and semiempirical models. Among them, Sodeifian et al., Bian et al., MST, and Bartle et al. models can more accurately correlate experimental data for the binary system than other used models. Also, the Sodeifian and Sajadian model well fitted the solubility data of the ternary system with AARD% = 6.45, Radj = 0.995.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations

Sodeifian

Sajadian

Razmimanesh

et al. 2021

Sci Rep

Self Cite

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show abstract

“…In our previous study, the reliability of the solubility setup was evaluated by determining the solubility of naphthalene and alpha-tocopherol in SC-CO2 at different pressures and temperatures and comparing them with the corresponding data in the literature 55 . In general, the authors systematically check and calibrate the device before testing naphthalene and alphatocopherol solubilities in SC-CO2.…”

Section: Binary Systemmentioning

confidence: 99%

Solubility of the Ketoconazole (an Antifungal Drug) in Supercritical Carbon Dioxide and Menthol as a Cosolvent (Ternary System): Experimental Data and Empirical Correlations

Sodeifian¹,

Sajadian²,

Razmimanesh³

et al. 2021

Preprint

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One of the main steps in choosing the drug nanoparticle production processes by supercritical carbon dioxide (SC-CO2) is determining the solubility of the solid solute. For this purpose, the solubility of Ketoconazole (KTZ) in the SC-CO2, binary system, as well as in the SC-CO2-menthol (cosolvent), ternary system, was measured at 308–338 K and 12–30 MPa using the static analysis method. The KTZ solubility in the SC-CO2 ranged between 1.70×10− 6 and 8.02×10− 4, while drug solubility in the SC-CO2 with cosolvent varied from 2.7×10− 5 to 1.96×10− 4. This difference indicated the significant effect of menthol cosolvent on KTZ solubility in the SC-CO2. Moreover, KTZ solubilities in the two systems were correlated by several empirical and semiempirical models. Among them, Sodeifian et al., Bian et al., MST, and Bartle et al. models can more accurately correlate experimental data for the binary system than other used models. Also, the Sodeifian and Sajadian model well fitted the solubility data of the ternary system with AARD,%= 6.45, Radj= 0.995.

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“…Figure 2 shows the line diagram of the equipment used in the study. More details about the solubility measuring device have been presented in our earlier studies [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] . However, a brief outline of the same is presented in this section.…”

Section: Experiments Detailsmentioning

confidence: 99%

Measurement and Modeling of Clemastine Fumarate (Antihistamine Drug) Solubility in Supercritical Carbon Dioxide

Sodeifian

Garlapati²,

Razmimanesh

et al. 2021

Preprint

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The solubilities of clemastine fumarate in supercritical carbon dioxide) ScCO2( were measured for the first time at temperature (308 to 338 K) and pressure (12 to 27 MPa). The measured solubilities were reported in terms of mole faction and it is ranged from 1.61 ×10− 6 to 9.41×10− 6. Various models were used to correlate the data. The efficacy of the models was quantified with corrected Akaike’s information criterion (AICc). A new cluster salvation model was derived to correlate the solubility data. The new model was able to correlate the data and deviation was 10.3% in terms of average absolute relative deviation (AARD). Furthermore, the measured solubilities were also correlated with existing K.-W. Chen et al., cluster salvation model, equation of state (EoS) model and few density models. Among density models, Tippana and Garlapati model was observed to be the best model and corresponding AARD% was 7.57 (corresponding AICc is -678.88). The Peng-Robinson equation of state as temperature independent was able to correlate the data and deviation was 8.25% in terms of AARD% (corresponding AICc is -674.88). Moreover, thermodynamic enthalpies of clemastine fumarate were estimated.

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Determination of solubility of Aprepitant (an antiemetic drug for chemotherapy) in supercritical carbon dioxide: Empirical and thermodynamic models

Cited by 106 publications

References 37 publications

Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations

Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: measurements and empirical correlations

Solubility of the Ketoconazole (an Antifungal Drug) in Supercritical Carbon Dioxide and Menthol as a Cosolvent (Ternary System): Experimental Data and Empirical Correlations

Measurement and Modeling of Clemastine Fumarate (Antihistamine Drug) Solubility in Supercritical Carbon Dioxide

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