Determination of soluble ICAM-1 and TNFalphaR in the cerebrospinal fluid and serum levels in a population of Brazilian patients with relapsing-remitting multiple sclerosis

Alves-Leon, Soniza Vieira; Batista, Elizabeth; Papais-Alvarenga, Regina María; Quirico-Santos, Thereza

doi:10.1590/s0004-282x2001000100005

Cited by 13 publications

(3 citation statements)

References 35 publications

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“…Both I/P and conceptualization subscales were significantly influenced by schooling in all subgroups. The influence of schooling on verbal fluency, presented in the I/P subscale and accounting for more than half of the subscale total, was observed in studies carried out by Brucki 26 and Caramelli et al 27 The conceptualization subscale contains tasks related to semantic memory. Porto et al.…”

Section: Discussionmentioning

confidence: 94%

The influence of schooling on performance in the Mattis Dementia Rating Scale (DRS)

Porto

Caramelli

Nitrini

2010

Dement. neuropsychol.

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Studies have shown the influence of schooling on performance in the Dementia Rating Scale (DRS), suggesting that a single cut-off score is not appropriate for all groups of elderly people.ObjectivesTo verify the influence of schooling on the DRS in a Brazilian elderly population.MethodsThe DRS was applied to 118 cognitively healthy controls and to 97 patients with mild probable Alzheimer’s disease (AD). In order to analyze the influence of education, patients and controls were divided into four groups of schooling (GRSC): GRSC 1 with 1 to 4 years of schooling, GRSC 2 with 5 to 8 years of schooling, GRSC 3 with 9 to 11 years of schooling, and GRSC 4 with more than 11 years of schooling.ResultsIn the intragroup analysis, the performance of controls within each schooling group was compared, revealing a significant difference on total score and the subscales Attention, I/P and Conceptualization. The same procedure was used for the AD patients and a significant difference was observed for total score and the subscales Attention, Construction, Conceptualization and Memory. In the intergroup analysis, the results on total DRS and for the I/P, Conceptualization and Memory subscales showed significant differences in GRSC 1, 2, 3 and 4. The Attention subscale showed differences in GRSC 3 and 4, and on the Construction subscale in GRSC 1 and 4.ConclusionsThe results highlight the importance of norms for the DRS in the Brazilian population that take into account the effects of schooling on the scores of this scale.

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Section: Discussionmentioning

confidence: 94%

The influence of schooling on performance in the Mattis Dementia Rating Scale (DRS)

Porto

Caramelli

Nitrini

2010

Dement. neuropsychol.

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“…Several attempts have been made in previous studies to assess serum sICAM-1 levels in RRMS patients. Researchers have observed increased expression of ICAM-1 and elevated serum sICAM-1 levels not only at the onset of clinical symptoms but also during clinical remission (Alves-Leon, Batista, Papais-Alvarenga, & Quírico-Santos, 2001;Doerck et al, 2010). Alves-Leon, Batista, Papais-Alvarenga, and Quírico-Santos.…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Biomarkers of Immune Activation and Associations With Neurological Impairment in Relapsing-Remitting Multiple Sclerosis Patients During Remission

Witkowska

Socha

Kochanowicz

et al. 2015

Biological Research For Nursing

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Although a decreased sICAM-1 concentration was observed in RRMS patients in remission as compared to healthy controls, sICAM-1 seemed to reflect neurological impairment and clinical disability. These data suggest that increasing serum sICAM-1 levels may be associated with progression of cerebellar or brain stem perturbations. However, further studies are required to confirm these findings in a larger population of RRMS patients.

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“…Likewise, the differential expression of cytokines directly involved in RRMS pathogenesis might also indicate disease status. However, their biomarker potential (5) has been validated for application in clinical practice only in a few cases. We conducted a pilot cross-sectional study to investigate the biomarker potential of pNF-H and several cytokines for disability in patients with 5-year RRMS evolution.…”

Section: Introductionmentioning

confidence: 99%

A Pilot Cross-Sectional Study to Investigate the Biomarker Potential of Phosphorylated Neurofilament-H and Immune Mediators of Disability in Patients With 5 Year Relapsing-Remitting Multiple Sclerosis

et al. 2019

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Objective: To test the feasibility of conducting a full-scale project evaluating the potential value of the phosphorylated neurofilament H (pNF-H) and several cytokines as disability markers in relapsing-remitting multiple sclerosis (RRMS).Methods: Twenty-four patients with 5-year RRMS evolution and eleven healthy control subjects entered the study. None of the participants had an inflammatory systemic or metabolic disease. Disability progression was evaluated using the Expanded Disability Status Scale. Serum level of pNF-H, the anti-inflammatory cytokine transforming growth factor-β 1 (TGF-β1), and the pro-inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-17A (IL-17A), monocyte chemotactic protein-1 (MCP-1), and soluble intercellular cell-adhesion molecule 1 (sICAM-1) were quantified using enzyme-linked immunosorbent assay (ELISA).Results: The patients had higher serum level of TGF-β1, IL-6, sICAM-1, and pNF-H. Based on these findings, a sample of at least 49 controls and 89 recent-onset RRMS patients is required to find an at least 1-point between-group difference in pNF-H with a power of 80% and an α error = 0.05. The progression of the disease was correlated with the level of pNF-H (Spearman rho = 0.624, p = 0.006), but not with the cytokines'.Conclusions: The serum level of pNF-H, EDSS score-correlated, might stand for a potential biomarker of disability in RRMS reflecting progressive axonal damage and cumulative neurological deterioration. The novelty of these results warrants conducting a larger confirmatory trial.

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Determination of soluble ICAM-1 and TNFalphaR in the cerebrospinal fluid and serum levels in a population of Brazilian patients with relapsing-remitting multiple sclerosis

Cited by 13 publications

References 35 publications

The influence of schooling on performance in the Mattis Dementia Rating Scale (DRS)

The influence of schooling on performance in the Mattis Dementia Rating Scale (DRS)

Serum Levels of Biomarkers of Immune Activation and Associations With Neurological Impairment in Relapsing-Remitting Multiple Sclerosis Patients During Remission

A Pilot Cross-Sectional Study to Investigate the Biomarker Potential of Phosphorylated Neurofilament-H and Immune Mediators of Disability in Patients With 5 Year Relapsing-Remitting Multiple Sclerosis

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