Determination of stability constants of ternary copper(II) complexes formed with picolinic acid and several amino acids

Hernández, Lino; Carpio, Edgar Del; Madden, Waleska; Lubes, Giuseppe; Pérez, Alejandro; Rodríguez-Lugo, Rafael E.; Landaeta, Vanessa R.; Araujo, Mary Lorena; Martínez, José Daniel; Lubes, Vito

doi:10.1080/00319104.2018.1534235

Cited by 18 publications

(13 citation statements)

References 22 publications

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“…In Table , the p K a values of the ligands studied in this work are shown. Good agreement is observed between the values determined in this work and the values reported in the literature − and stability constants databases. , …”

Section: Resultssupporting

confidence: 87%

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Speciation of the Ternary Cobalt(II) Picolinic and Dipicolinic Acid Complexes with Small Bioligands

Chacón,

Araujo,

Hernández Mazzocchin

et al. 2023

J. Chem. Eng. Data

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This study reports on the determination of stability constants for ternary cobalt(II) complexes using primary ligands, pyridine carboxylic acids (picolinic (HPic) and dipicolinic (H2Dipic) acids), along with secondary ligands: lactic acid (HLac, HL), oxalic acid (H2Ox, H2L), citric acid (H3Cit, H3L), and phosphoric acid (H3PO4, H3L). Potentiometric data for binary cobalt(II) bioligand complexes and ternary cobalt(II) pyridine carboxylic acid and bioligand complexes were analyzed using the computational program LETAGROP. The experiments were conducted in an ionic medium of 1.0 mol dm–3 NaNO3 at 25 °C. Species distribution diagrams were generated, and relative stability parameters Δlog10 K, log10 X, and % R.S. were calculated. These findings may have important implications for the design of new cobalt(II) complexes for various applications.

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Section: Resultssupporting

confidence: 87%

“… a Values in parentheses represent 3 times the standard deviations [3σ(log 10 β pr )] on the last significant figure. b 1.0 mol dm –3 KNO 3 c 1.0 mol dm –3 NaCl, 25 °C …”

Section: Resultsmentioning

confidence: 99%

Speciation of the Ternary Cobalt(II) Picolinic and Dipicolinic Acid Complexes with Small Bioligands

Chacón,

Araujo,

Hernández Mazzocchin

et al. 2023

J. Chem. Eng. Data

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“…The positive values observed for all the amino acids HL used in this work indicate that ternary complexes are more stable than their binary counterparts, ,, which is also confirmed in the speciation diagrams of all studied ternary systems.…”

Section: Resultssupporting

confidence: 80%

“…The stability of the ternary compounds was evaluated with respect to the binary ones by means of Δlog K, which was determined ,, using the following equilibria: false[ Fe ( Pic ) false] + + false[ Fe ( L ) false] + ⇌ [ Fe false( Pic false) false( normalL false) ] + Fe 2 + , normalΔ log .25em K normalΔ log K = log .25em β ( Fe false( Pic false) false( normalL false) ) − ( log β false( Fe ( Pic ) false) + log β false( Fe ( L ) false) ) …”

Section: Resultsmentioning

confidence: 99%

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Speciation Studies of Binary and Ternary Complexes Formed with Fe(II) Ion, Picolinic Acid, and Several Amino Acids

Rodriguez,

González,

Araujo

et al. 2023

J. Chem. Eng. Data

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In this study, we investigate the chemical speciation of ternary complex systems involving Fe(II) ions, picolinic acid (HPic), and various amino acids, including α-alanine (HαAla), βalanine (HβAla), glycine (HGly), leucine (HLeu), lysine (HLys), methionine (HMet), phenylalanine (HPhe), serine (HSer), threonine (HThr), valine (HVal), proline (HPro), and histidine (H 2 His). Potentiometric titrations were conducted in an aqueous solution at 25 °C using a 1 mol dm −3 NaCl solution as the ionic medium. Data analysis was performed using the least-squares program LETAGROP. Our study also encompasses the investigation of Fe(II) hydrolysis products (hydroxylated complexes) and binary complexes formed by Fe(II) with picolinic acid and individual amino acids, all in aqueous solution at 25 °C, employing a 1.0 mol dm −3 NaCl medium. Species distribution diagrams were generated, and the relative stability parameter Δlog 10 K was calculated. These findings are significant for the potential design and application of novel Fe(II) complexes in various fields.

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Development of comprehensive approaches to characterizing Cu^II complexes: structures in solution and solid‐state, dynamic behavior, and bioactivity

Ermolaev,

Shtyrlin,

Gizatullin

et al. 2023

ChemistrySelect

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CuII ternary systems with aromatic N‐donors (1,10‐phenanthroline, dipyrido‐[3,2‐f:2’,3’‐h]‐quinoxaline, and 2‐methyldipyrido‐[3,2‐f:2’,3’‐h]‐quinoxaline) and amino acids have been extensively studied in water solution under closely physiological conditions using several techniques, including potentiometric pH titration, mathematical modeling, nuclear magnetic relaxation, EPR, and DFT calculations. Based on the distribution diagrams of the complex species, single crystal syntheses of the ternary systems CuII‐aromatic N‐donor‐L‐amino acid were carried out. As a result, several crystal structures of the complexes with the desired copper‐to‐ligand ratio were established by X‐ray diffraction analysis. The most successful synthetic attempts were with L‐proline and L‐serine, resulting in the crystals with the desired copper(II) to ligand ratio. The developed approach made it possible to thoroughly describe systems with major proteinogenic amino acids in the L‐configuration. Numerous non‐covalent interactions such as H‐bonds, π‐π stacking, d‐π interactions, lone electron pair‐π interactions between CuII atom, conjugated aromatic ligand system, counterions, and water molecules were found to affect the stability and structure of the resulting complex particles. It has been found that in the CuII–N‐donor–amino acid systems there is an acceleration of ligand exchange by a factor of 2–25 compared to CuII‐amino acid systems, which is explained by taking into account steric effects, d‐π interactions, and the pseudo Jahn‐Teller effect. The investigated systems were tested for antitumor activity against MCF‐7, PC‐3, OVCAR‐4, SNB‐19, and M‐14 cell lines, and most samples, in particular, CuII–Phen–L‐His, CuII–MeDPQ−L‐Val and CuII–MeDPQ−L‐Ser, showed a therapeutic activity index greater than 2 for all selected cell types, which opens up prospects for their medical application.

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Determination of stability constants of ternary copper(II) complexes formed with picolinic acid and several amino acids

Cited by 18 publications

References 22 publications

Speciation of the Ternary Cobalt(II) Picolinic and Dipicolinic Acid Complexes with Small Bioligands

Speciation of the Ternary Cobalt(II) Picolinic and Dipicolinic Acid Complexes with Small Bioligands

Speciation Studies of Binary and Ternary Complexes Formed with Fe(II) Ion, Picolinic Acid, and Several Amino Acids

Development of comprehensive approaches to characterizing Cu^II complexes: structures in solution and solid‐state, dynamic behavior, and bioactivity

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Determination of stability constants of ternary copper(II) complexes formed with picolinic acid and several amino acids

Cited by 18 publications

References 22 publications

Speciation of the Ternary Cobalt(II) Picolinic and Dipicolinic Acid Complexes with Small Bioligands

Speciation of the Ternary Cobalt(II) Picolinic and Dipicolinic Acid Complexes with Small Bioligands

Speciation Studies of Binary and Ternary Complexes Formed with Fe(II) Ion, Picolinic Acid, and Several Amino Acids

Development of comprehensive approaches to characterizing CuII complexes: structures in solution and solid‐state, dynamic behavior, and bioactivity

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Development of comprehensive approaches to characterizing Cu^II complexes: structures in solution and solid‐state, dynamic behavior, and bioactivity