Determination of Stimulants and Diuretics in Dietary Supplements for Weight Loss and Physical Fitness by Ion-pair Chromatography and Pulsed Amperometric Detection (PAD)

Müller, Larissa; Molin, Thaís Ramos Dal; Muratt, Diana Tomazi; Leal, Gabriela; Urquhart, Carolina Gonzalez; Viana, Carine; Carvalho, Leandro Machado de

doi:10.2174/1573411014666171229155726

Cited by 8 publications

(2 citation statements)

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“…e doping detection methods include gas chromatography, high-performance liquid chromatography, gas chromatography-mass spectrometry, liquid chromatography, mass spectrometry, chemiluminescence immunoassay, and electrochemistry [15][16][17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Research on Detection of Sterol Doping in Sports by Electrochemical Sensors: A Review

Yun-yan

2022

Journal of Analytical Methods in Chemistry

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The use of doping by athletes to improve performance is prohibited. Therefore, doping testing is an important step to ensure fairness in sports. Doping is gradually metabolized in the body and is therefore difficult to detect immediately by a common method. At the same time, the emergence of new doping agents poses a challenge for highly sensitive detection. Electrochemical sensors are a fast, highly sensitive, and inexpensive analytical detection technology. It provides qualitative and quantitative determination of analytes by altering the electrochemical signal of the analyte or probe at the electrode. In this min-review, we summarized the different electrochemical sensing strategies for sterol doping detection. Some of the representative papers were interpreted in detail. In addition, we compare different sensing strategies.

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Section: Introductionmentioning

confidence: 99%

Research on Detection of Sterol Doping in Sports by Electrochemical Sensors: A Review

Yun-yan

2022

Journal of Analytical Methods in Chemistry

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“…At present, various methods for detecting furosemide in slimming products have been reported, including capillary electrophoresis (CE) [9][10][11], ion migration spectrometry (IMS) [12], ion-pair chromatography (IPC) [13,14], liquid chromatography-tandem mass spectrometry (LC-MS/MS) [15], high performance liquid chromatography (HPLC) [16] and ultra-high-pressure liquid chromatography (UHPLC) [17,18]. All these methods rely on expensive equipment, which is difficult to operate and requires trained operators.…”

Section: Introductionmentioning

confidence: 99%

Lateral Flow Immunochromatography Assay for Detection of Furosemide in Slimming Health Foods

Xie

Wang

et al. 2021

Foods

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In recent years, furosemide has been found to be abused in slimming health foods. There is an urgent need for a simpler, faster method for detecting furosemide in slimming health foods. In this study, a rapid, convenient and sensitive lateral flow immunochromatography (LFIA) based on Au nanoparticles (AuNPs) was established for the first time. Under optimal conditions, the qualitative limit of detection (LOD) of the AuNPs-based LFIA was 1.0~1.2 μg/g in slimming health foods with different substrates. AuNPs-LFIA could specifically detect furosemide within 12 min (including sample pretreatment) and be read by the naked eye. The developed AuNPs-LFIA showed high consistency with liquid chromatography with tandem mass spectrometry (LC-MS/MS), and no false positive or false negative results were found in spiked slimming health foods, proving that the AuNPs-LFIA should be accurate and reliable. The AuNPs-LFIA reported here provides a serviceable analytical tool for the on-site detection and rapid initial screening of furosemide for the first time.

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A new approach to ion exchange chromatography with conductivity detection for adulterants investigation in dietary supplements

Molin

Silveira

Leal

et al. 2019

Biomedical Chromatography

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The extent of adulteration of dietary supplements has significantly increased in recent years. This situation worries health authorities and requires auxiliary analytical tools for the investigation of illegal substances purposely added. Ion exchange chromatography with conductivity detection is a consolidated analytical technique for the determination of inorganic compounds in various matrices. This technique has been applied to the pharmaceutical characterization of mainly impurities and degradation products. This work presents a new approach to ion exchange chromatography as a screening method to investigate the presence of amfepramone, femproporex, sibutramine, bisacodyl and amiloride in dietary supplements advertised for weight loss. The method was optimized and validated using a Metrosep C4 100/4.0 cation exchange column. The mobile phase consisted of 1.8 mm HNO3 containing 2% acetonitrile (v/v), with a flow rate of 0.9 ml min−1, and nonsuppressed conductivity detection was applied. The limits of detection and quantification varied from 1.01 to 3.62 mg L−1 and from 1.48 to 8.72 mg L−1, respectively. The proposed method was successful applied to 78 solid dietary supplement samples, in two of which adulterations were found. Moreover, ion exchange chromatography with conductivity detection could be easily used for quality control without prior complex sample pre‐treatment.

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Determination of Stimulants and Diuretics in Dietary Supplements for Weight Loss and Physical Fitness by Ion-pair Chromatography and Pulsed Amperometric Detection (PAD)

Cited by 8 publications

References 0 publications

Research on Detection of Sterol Doping in Sports by Electrochemical Sensors: A Review

Research on Detection of Sterol Doping in Sports by Electrochemical Sensors: A Review

Lateral Flow Immunochromatography Assay for Detection of Furosemide in Slimming Health Foods

A new approach to ion exchange chromatography with conductivity detection for adulterants investigation in dietary supplements

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