The objectives of this study were to compute diagnosis and recommendation integrated system (DRIS) norms and sufficiency ranges from a survey of tomato crops grown in Mediterranean greenhouses and the verification of their variation during plant growth and development. DRIS norms were computed from 408 samples of first young mature leaves collected during different phenological stages. Using the DRIS technique, two sufficiency ranges were developed: one includes all the database regardless of the phenological stage, and the other was developed based on the phenological stage. Also, ten DRIS norm nutrient ratios and cv were computed from N, P, K, Ca, and Mg analytical results. All the ratios in flowering (FL), and only N/K, Mg/K, and Mg/N in fruit development (FD), showed low cv and therefore may play a fundamental role in crop development in accord with the DRIS norms calculated. It is also necessary to point out that a slight modification in the nutrient concentration led to a large change in the nutritional balance of the plant. Moreover, the general sufficiency ranges developed were: N (25–48), P (2.6–4.7), K (16–31), Ca (23–36), and Mg (6.7–10 g·kg−1). In conclusion, this work may signify an improvement in the nutritional diagnosis of greenhouse tomatoes in the Mediterranean area, because there is great variability when setting DRIS standards and sufficiency ranges based on phenological stages compared with general DRIS norms and sufficiency ranges. Use of DRIS norms and sufficiency ranges will allow better nutritional adjustment based on the phenological stage of the crop.