Determination of Sulfonamides and Local Anesthetics with 9-Chloroacridine by Quenching Fluorometry

Stewart, James T.; Wilkin, R.E.

doi:10.1002/jps.2600610325

Cited by 13 publications

References 7 publications

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Electroanalytical study of succinylsulfathiazole and phtalylsulfathiazole at a glassy carbon electrode

1989

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An electroanalytical study of succinylsulfathiazole and phtalylsulfathiazole oxidation processes at a glassy carbon electrode using different voltammetric techniques was carried out. Results obtained at a rotating disk electrode allow the determination of the pK, values of the reduced and oxidized forms. Limiting currents are diffusion controlled in concentration ranges of 1.0 X mol L-' for succinylsulfathiazole and phtalylsulfathiazole, respectively. Adsorption phenomena occur at higher concentrations, becoming stronger as the acidity of the medium increases. From differential pulse voltammeuy at a stationary electrode, the limits of determination were 3.7 X and 4.7 x mol L-' for succinylsulfathiazole and phtalylsulfathiazole, respectively. Interferences between the two sulfa drugs were studied. The application of Merentid pulse voltammetry at a stationary electrode gave good results for the determination of phtalylsulfathiazole in a commercid pharmaceutical preparation. to 5.0 x and 2.0 X to 6.0 x

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Electroanalytical study of succinylsulfathiazole and phtalylsulfathiazole at a glassy carbon electrode

1989

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Fluorescence Analysis

King¹,

Miller²

1986

Analytical Methods in Human Toxicology

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Fluorimetric Determination of Sulphaguanidine and Sulphamethoxazole by Host-Guest Complexation in β-Cyclodextrin and Partial Least Squares Calibration

et al. 2007

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The host-guest inclusion complexes of sulphamethoxazole (SMTX) and sulphaguanidine (SGN) with beta-cyclodextrin, in aqueous solutions, have been investigated. A 1:1 stoichiometry of the complexes was established, the association constants were calculated by different methods, and the influence of several chemical variables on the complexation processes were established. According to the results obtained, a spectrofluorimetric method for the determination of these sulphonamides has been proposed. The individual and binary mixtures of both sulphonamides have been determined in human urine samples, at representative therapeutic ranges, by application of a first-order multivariate calibration partial least squares (PLS-1) model. The calibration set was designed with 9 samples, containing different concentrations of the two sulphonamides, and 8 blank urine samples, with the aim of modelling the variability of the background. The concentration ranges for the sulphonamides were up to 0.5 microg mL(-1) for SMTX and 1.0 microg mL(-1) for SGN. Figures of merit as selectivity, analytical sensitivity and limit of detection (LOD) were also calculated. The proposed procedure was validated by comparing the obtained results with a HPLC method, with satisfactory results for the assayed method.

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Determination of Sulfonamides and Local Anesthetics with 9-Chloroacridine by Quenching Fluorometry

Cited by 13 publications

References 7 publications

Electroanalytical study of succinylsulfathiazole and phtalylsulfathiazole at a glassy carbon electrode

Electroanalytical study of succinylsulfathiazole and phtalylsulfathiazole at a glassy carbon electrode

Fluorescence Analysis

Fluorimetric Determination of Sulphaguanidine and Sulphamethoxazole by Host-Guest Complexation in β-Cyclodextrin and Partial Least Squares Calibration

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