Determination of sulfonamides in milk by ID-LC-MS/MS

Unsal, Isin Aydin; Taşan, Murat; Gökçen, Taner; Goren, Ahmet C.

doi:10.25135/jcm.15.18.04.081

Cited by 8 publications

(4 citation statements)

References 34 publications

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“…ABZ sulfone was detected 5.2 µg/kg and confirmed, thiabendazole was detected in two cheese samples trace around 0.7 µg/kg. Unsal et al [27] have developed and validated isotope-dilution LC with MS with heated ESI Source method for estimation of Sulfa + in 14 milk samples obtained from market and street vendors. Recovery results were found between 91 and 114% and relative measurement uncertainty was measured between 7.5 and 12.7%.…”

Section: Lc-msmentioning

confidence: 99%

Assessment of various veterinary drug residues in animal originated food products

Parmar

Chaubey

Gupta³

et al. 2021

Vet World

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The veterinary drugs are broad-spectrum antibacterial antibiotics; it uses to cure the animal disease. Many countries have banned veterinary drug residues like nitrofurans metabolites, chloramphenicol. However, the people were administrated veterinary drugs to animals as illegal to increase the milk production in animals for economic benefit. The results of illegally use of veterinary drugs remain as a residue in animal product like milk and it is very harmful to whom consume it cause cancer and allergic for human being which has entered the concern among milk consumers. To control illegal use of veterinary drugs, the government of India has restricted its use in animals. For the identification and confirmation of veterinary drug residues in animal products, analytical techniques such as liquid chromatography and mass spectrometry are available. These are very sophisticated equipments which are available nowadays and their methodologies for the analytical method validation are described by European commission 2002/657/EC. The use of veterinary drugs is a big challenge to effectively identify and authorization of their use. There are so many analytical techniques are using very effectively and taking very less time to protect the consumers from their adverse effects. These techniques take very less time to identify more groups of compounds such as tetracycline, sulfonamides, anthelmintic, and macrolides in single multi-residue method. These methods having validation parameters include system precision, calibration curve, accuracy, limit of detection, and quantification. Therefore, improvement in the existing technologies and accessibility of new screening methodologies will give opportunities for automation that helps in obtaining the results in very less time and improved sensitivity and specificity which contribute to better safety assurance, standard, and quality of various food products of animal origin.

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Section: Lc-msmentioning

confidence: 99%

Assessment of various veterinary drug residues in animal originated food products

Parmar

Chaubey

Gupta³

et al. 2021

Vet World

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“…Analytical methods for the determination of pharmaceutical drugs in milk have undergone considerable development in recent years. Milk sample preparation techniques based on liquid-liquid extraction (LLE) [9] have been replaced by other approaches, such as solid-phase extraction (SPE) [10,11], solid-liquid extraction (SLE) [5], matrix solid phase dispersion (MSPD) extraction [12,13], solid-phase microextraction (SPME) [14], and more recently by QuEChERS extraction [7,8,[15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Determination of Multiclass Pharmaceutical Residues in Milk Using Modified QuEChERS and Liquid-Chromatography-Hybrid Linear Ion Trap/Orbitrap Mass Spectrometry: Comparison of Clean-Up Approaches and Validation Studies

Koloka,

Koulama,

Hela

et al. 2023

Molecules

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A multi-residue method was developed to identify and quantify pharmaceutical drug residues in full-fat milk, using a modified QuEChERS extraction procedure and sonication combined with Ultra-High-Performance Liquid Chromatography–High-Resolution Orbitrap Mass Spectrometry (UHPLC-HR-Orbitrap-MS). Sample preparation involves three different QuEChERS extraction procedures and sorbents for the purification step. The optimized modified extraction method, combined with the clean-up approaches using C18 and the EMR-Lipid sorbent, has been validated in terms of linearity, recovery, precision, LOD and LOQ, matrix effects (ME) and expanded uncertainty. The optimized method showed a linearity >0.9903, recoveries within the range 65.1–120.1%, precision (expressed as %RSD) <17.5%, medium (<39.9%) to low (<16.7%) matrix effects and acceptable expanded uncertainty (<33.1%). Finally, the proposed method was applied to representative real samples of milk (by local markets), revealing the existence of one pharmaceutical drug (imidocarb) in one sample.

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“…It is widely used in veterinary practice to treat livestock diseases such as gastrointestinal and respiratory tract infections. 14 Various methods were reported for SDD determination, such as LC-MS/MS, 15 HPLC. 16,17 …”

Section: Introductionmentioning

confidence: 99%

Eco-friendly multivariate curve resolution-alternating least squares and chromatographic quantifications of some veterinary drug residues in pharmaceutical industrial wastewater

et al. 2021

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Determination of sulfonamides in milk by ID-LC-MS/MS

Cited by 8 publications

References 34 publications

Assessment of various veterinary drug residues in animal originated food products

Assessment of various veterinary drug residues in animal originated food products

Determination of Multiclass Pharmaceutical Residues in Milk Using Modified QuEChERS and Liquid-Chromatography-Hybrid Linear Ion Trap/Orbitrap Mass Spectrometry: Comparison of Clean-Up Approaches and Validation Studies

Eco-friendly multivariate curve resolution-alternating least squares and chromatographic quantifications of some veterinary drug residues in pharmaceutical industrial wastewater

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