Determination of Suramin in Plasma and Urine by Ion-Paired Reverse-Phase High-Performance Liquid Chromatography

Stolzer, Thomas J.; Lafollette, Greg; Gambertoglio, John G.; Aweeka, Francesca; Lin, Emil T.

doi:10.1080/01483918708081883

Journal of Liquid Chromatography

1987

DOI: 10.1080/01483918708081883

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Determination of Suramin in Plasma and Urine by Ion-Paired Reverse-Phase High-Performance Liquid Chromatography

Thomas J. Stolzer

Greg Lafollette

John G. Gambertoglio

et al.

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Cited by 7 publications

References 4 publications

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Evidence of an absorption phase after short intravenous suramin infusions

Hutson¹,

Tutsch²,

Springgs³

et al. 1993

Cancer Chemother. Pharmacol.

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Suramin was given as an intravenous infusion to 16 cancer patients in a phase I trial. Individual pharmacokinetic parameters were calculated from a test dose given 1 week prior to the administration of a full-dose (350-700 mg/m2) regimen of 1-h loading and maintenance infusions. A distribution phase of 3.8 h was found. Plasma suramin concentrations were noted to increase following cessation of the intravenous test infusion in eight subjects. A model is proposed in which high-capacity, low-affinity binding of suramin to a shallow compartment adjacent to the intravascular space occurs rapidly during infusion, followed by absorption back into the measured blood pool with binding to plasma albumin. Despite the observable presence of this postinfusion peak shortly after the cessation of the brief suramin infusion, the pharmacokinetics of suramin were best characterized by a traditional two-compartment model. The dose-adjusted area under the concentration-time curve (AUC) increased with dose, supporting a hypothesis of sustained absorption of suramin to vascular endothelium but also raising the possibility of dose-dependent clearance.

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Evidence of an absorption phase after short intravenous suramin infusions

Hutson¹,

Tutsch²,

Springgs³

et al. 1993

Cancer Chemother. Pharmacol.

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Efficacy of suramin against human prostate carcinoma DU145 xenografts in nude mice

Church

Zhang

Rago

et al. 1999

Cancer Chemotherapy and Pharmacology

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Suramin, without concomitant corticosteroid therapy, was effective in slowing the growth of DU145 xenografts in nude mice at clinically relevant plasma suramin levels. The data showing efficacy for DU145 xenografts was supported by the lack of efficacy at the same time for xenografts of cells known to be less responsive to suramin in vitro, i.e. the SR DU145 cells, at similar doses and nadir plasma suramin levels. In discussions on the utility of suramin our data should be considered as support for continuing the study of suramin in the treatment of advanced, androgen-independent prostate cancer.

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Precision in capillary electrophoresis with respect to quantitative analysis of suramin

Hettiarachchi

Cheung

1995

Journal of Chromatography A

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Determination of Suramin in Plasma and Urine by Ion-Paired Reverse-Phase High-Performance Liquid Chromatography

Cited by 7 publications

References 4 publications

Evidence of an absorption phase after short intravenous suramin infusions

Evidence of an absorption phase after short intravenous suramin infusions

Efficacy of suramin against human prostate carcinoma DU145 xenografts in nude mice

Precision in capillary electrophoresis with respect to quantitative analysis of suramin

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