1995
DOI: 10.1016/0378-4347(94)00449-f
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Determination of terbinafine and its desmethyl metabolite in human plasma by high-performance liquid chromatography

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Cited by 53 publications
(37 citation statements)
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“…The concentrations of terbinafine and its N-demethyl (SDZ 86-621), carboxybutyl (SDZ 280-027), and N-demethyl-carboxybutyl (SDZ 280-047) metabolites in plasma, urine, and tissue samples were determined by validated and sensitive high-performance liquid chromatography methods (3,14). Standard curves were constructed independently for each biological matrix and analyte.…”
Section: Methodsmentioning
confidence: 99%
“…The concentrations of terbinafine and its N-demethyl (SDZ 86-621), carboxybutyl (SDZ 280-027), and N-demethyl-carboxybutyl (SDZ 280-047) metabolites in plasma, urine, and tissue samples were determined by validated and sensitive high-performance liquid chromatography methods (3,14). Standard curves were constructed independently for each biological matrix and analyte.…”
Section: Methodsmentioning
confidence: 99%
“…The quantitative determination of T HCl pharmacokinetics in the rabbit aqueous humor was based on a previously validated HPLC method using a Merck Hitachi LaChrom HPLC system (Darmstadt, Germany) (29). A reversed phase micro-particulate Agilent® C 18 column (150×4.6 mm, 5 μm; Kansas) was attached.…”
Section: Estimation Of Drug Pharmacokinetics In the Aqueous Humor Of mentioning
confidence: 99%
“…Literature survey revealed that no HPTLC method has been reported for the estimation of Terbinafine Hydrochloride. The present investigation has been undertaken to develop simple HPTLC in pure form and its formulations 3,4,5,6,7 .…”
Section: Fig 1: Structural Formula Of Terbinafine Hydrochloridementioning
confidence: 99%