Determination of terbutaline sulfate by capillary electrophoresis with chemiluminescence detection

Li, Shuting; Wang, Janshi; Zhao, Shulin

doi:10.1016/j.jchromb.2008.11.042

Cited by 31 publications

(22 citation statements)

References 18 publications

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“…The value of TER obtained in the analysis was in good agreement with the labelled value. Data obtained in this study were in good comparison to the literature values including an analytical procedure with recoveries from 98.4 % to 99.2 % (RSDs from 3.2 to 4.3) using capillary electrophoresis , a voltammetric method utilizing a composite of graphene, nafion and poly(arginine) modified electrode with average recoveries of 101.3 %∼103.0 % with an RSD of 1.0 , and anodic stripping voltammetry at GCEs with a recovery of 98.7 % with an RSD of 1.7 . A urine sample was analysed by the Eu 2 O 3 NPs/CNTs/GCE system.…”

Section: Resultsmentioning

confidence: 99%

Sensitive Determination of Terbutaline Using a Platform Based on Nanoparticles of Europium Oxide and Carbon Nanotubes

Teker

Aslanoğlu

2018

Electroanalysis

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This study presents a sensitive voltammetric determination of terbutaline (TER) on a platform based on carbon nanotubes (CNTs) and europium oxide nanoparticles (Eu2O3NPs) coated glassy carbon electrodes (GCEs). An ultrasonic bath was performed for the preparation of composite material. The material was characterized by energy dispersive X‐ray spectroscopy (EDX), X‐ray diffraction method (XRD) and scanning electron microscopy (SEM). The Eu2O3NPs/CNTs/GCE system was assessed for the oxidation of terbutaline (TER). A broad oxidation peak was appeared at 0.71 V using a bare GCE. However, the voltammetry of TER has been improved at a GCE coated with CNTs and a well‐defined anodic peak exhibited at 0.61 V. Furthermore, the nanoparticles of Eu2O3 and CNTs coated GCE has greatly improved the electrochemical behaviour of TER and a sharp peak was appeared at 0.59 V. Cyclic voltammetry at Eu2O3NPs/CNTs/GCE also reveals a high catalytic effect for the oxidation of TER with an oxidation peak that is distinctly enhanced compared to GCE and CNTs/GCE. Eu2O3 nanoparticles were utilized to enhance the surface area of GCE and then improve the sensitivity of the procedure. The response of TER was linear over a concentration range of 2.0×10−8 M −9.5×10−6 M with an LOD of 3.7×10−9 M. Square wave voltammetric analysis of tablets by Eu2O3NPs/CNTs/GCE yielded a recovery of 99.2 % with an RSD% of 3.2. The modified electrode (EuO2NPs/CNTs/GCE) provides accuracy and precision to the analysis of samples.

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Section: Resultsmentioning

confidence: 99%

Sensitive Determination of Terbutaline Using a Platform Based on Nanoparticles of Europium Oxide and Carbon Nanotubes

Teker

Aslanoğlu

2018

Electroanalysis

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“…1,2 A literature survey revealed that various analytical methods have been reported for the estimation of TBS; they include UV spectroscopy, 3,4 voltammetry, 5,6 capillary electrophoresis, [7][8][9] chemiluminescence, [10][11][12] high performance liquid chromatography (HPLC), 1,13,14 HPLC-fluorescence detection, 15 HPLC-electrochemical detection, 16,17 HPLCchemiluminescence detection, 18 RP-liquid chromatography, 19 LC-electrochemical detection, 20 column-switching LC, 21 LC-tandem mass spectrometry, 22,23 and high-resolution GC-mass spectrometry analysis. 24 For TBS pharmacokinetic studies, the most useful analytical method is GC-mass spectrometry.…”

Section: Terbutaline Sulfate (Tbs); β-[(Tert-butylamino)methyl]-35-mentioning

confidence: 99%

Stability indicating HPTLC method for determination of terbutaline Sulfate in bulk and from Submicronized dry Powder inhalers

et al. 2010

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A stability-indicating high-performance thin-layer chromatographic (HPTLC) method has been developed for the determination of terbutaline sulfate (TBS) as a bulk drug and in pharmaceutical formulations (submicronized dry powder inhalers). The separation was achieved on TLC aluminum plates precoated with silica gel 60F-254 using chloroform-methanol (9.0:1.0 v/v) as mobile phase. The densitometric analysis was carried out at 366 nm wavelength. Compact spots appeared at Rf = 0.34 ± 0.02. For the proposed procedure, linearity (r 2 = 0.9956 ± 0.0015), limit of quantification (28.35 ng spot -1 ), limit of detection (9.41 ng spot -1 ), recovery (97.06 -99.56%), and precision (≤1.86) were found to be satisfactory. TBS was subjected to acid and alkali hydrolyses, oxidation and photodegradation treatments. The degraded products were well separated from the pure drug. Statistical analysis reveals that the developed method has potential for routine analysis and stability testing of terbutaline sulfate in pharmaceutical drug delivery systems.

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“…Different analytical techniques have been developed for determination of terbutaline sulfate and tetracycline. HPLC, 8,9 LC-MS, 10 CE, 11 CE-MS, 12 voltammetry, 13 electrochemical method, 14,15 liquid chromatography, 16,17 capillary electrophoresis 18 and chemiluminescence 19,20 have been reported for determination of tetracycline. These methods are often time-consuming, expensive, and cumbersome.…”

Section: Introductionmentioning

confidence: 99%

Spectrofluorimetric Determination of Tetracycline and Terbutaline Sulphate in Its Pure and Dosage Forms Using Eosin Y Reagent

Al-Sabha¹,

Dhamra²,

Al-Ghabsha³

2017

ECB

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A spectrofluorimetric method has been developed for the determination of tetracycline hydrochloride and terbutaline sulphate in different dosage forms. The method is based on the quantitative quenching effect of tetracycline hydrochloride and terbutaline sulphate on the native fluorescence of Eosin Y at the pH 6.4 and 3.5 respectively. The quenching of the fluorescence of Eosin Y was measured at 545 nm after excitation at 350 nm. The fluorescence-concentration plots are rectilinear over the range 0.5-18 and 0.05-5.0 μg mL -1 with LOD of 0.531 and 0.241 μg mL -1 and LOQ of 1.77 and 0.806 μg mL -1 for above drugs respectively. The proposed method has been successfully applied to the analysis of commercial tablets and capsules containing the drug. Statistical comparison of the results with those of the reference method revealed good agreement and proved that there were no significant differences in the accuracy and precision between the two methods.* Corresponding Authors E-Mail: dr_theiaa@yahoo.co.uk [a]

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Determination of terbutaline sulfate by capillary electrophoresis with chemiluminescence detection

Cited by 31 publications

References 18 publications

Sensitive Determination of Terbutaline Using a Platform Based on Nanoparticles of Europium Oxide and Carbon Nanotubes

Sensitive Determination of Terbutaline Using a Platform Based on Nanoparticles of Europium Oxide and Carbon Nanotubes

Stability indicating HPTLC method for determination of terbutaline Sulfate in bulk and from Submicronized dry Powder inhalers

Spectrofluorimetric Determination of Tetracycline and Terbutaline Sulphate in Its Pure and Dosage Forms Using Eosin Y Reagent

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