Determination of tetracycline using imprinted polymethacrylates along with fluorescent CdTe quantum dots on plastic substrates

Chen, Jian‐Lian

doi:10.1007/s00604-017-2118-2

Cited by 30 publications

(21 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One form of solid-phase MI-FL microdevices is a test strip, which can be simply proposed by grafting MI-FL sensors on a proper substrate to fully integrate their respective advantages but is rarely reported (Chen, 2017;Zhang et al, 2016). Taking a polyimide-based test strip as an example, Chen (2017) invented a test strip for tetracycline detection by bonding MIP-QDs composites to methacrylated polyimide (PI) substrates, as illustrated in Fig. 14.…”

Section: Test Stripmentioning

confidence: 99%

Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis

Yang

Wang

et al. 2018

Biosensors and Bioelectronics

327

126

View full text Add to dashboard Cite

One pressing concern today is to construct sensors that can withstand various disturbances for highly selective and sensitive detecting trace analytes in complicated samples. Molecularly imprinted polymers (MIPs) with tailor-made binding sites are preferred to be recognition elements in sensors for effective targets detection, and fluorescence measurement assists in highly sensitive detection and user-friendly control. Accordingly, molecular imprinting-based fluorescence sensors (MI-FL sensors) have attracted great research interest in many fields such as chemical and biological analysis. Herein, we comprehensively review the recent advances in MI-FL sensors construction and applications, giving insights on sensing principles and signal transduction mechanisms, focusing on general construction strategies for intrinsically fluorescent or nonfluorescent analytes and improvement strategies in sensing performance, particularly in sensitivity. Construction strategies are well overviewed, mainly including the traditional indirect methods of competitive binding against pre-bound fluorescent indicators, employment of fluorescent functional monomers and embedding of fluorescence substances, and novel rational designs of hierarchical architecture (core-shell/hollow and mesoporous structures), post-imprinting modification, and ratiometric fluorescence detection. Furthermore, MI-FL sensor based microdevices are discussed, involving micromotors, test strips and microfluidics, which are more portable for rapid point-of-care detection and in-field diagnosing. Finally, the current challenges and future perspectives of MI-FL sensors are proposed.

show abstract

Section: Test Stripmentioning

confidence: 99%

Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis

Yang

Wang

et al. 2018

Biosensors and Bioelectronics

327

126

View full text Add to dashboard Cite

show abstract

“…Polyimide (PI) is one of the materials most used as a plastic substrate. For improving the adhesion of coating materials on the chemically inert PI substrate, electron beam [9], laser [10], ion beam [11], ultraviolet (UV)/O 3 radiation [12], gamma-ray [13], plasma [14][15][16][17][18], and chemicals [19][20][21], have been applied to PI surfaces before coating. In contrast with the dry treatments, wet chemical modification possesses lower instrument expenses but more tedious procedures.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to a few studies on precursor film deposition [22,23], physical ion bombardments, which create hydrophilicity and roughness on PI surfaces, are used to enhance the peel strength of metals and metal composites. To the best of our knowledge, sensors fabricated with dry modification of PIs have not been described to date, although chemical modification of PIs has been used as a substrate for bonding quantum dots (QDs) as fluorescent sensors in our previous study [21].…”

Section: Introductionmentioning

confidence: 99%

Effective and Efficient Pretreatment of Polyimide Substrates by Capacitively Coupled Plasma for Coating the Composites of Tetracycline-Imprinted Polymers and Quantum Dots: Comparison with Chemical Pretreatment

Chen

2020

Sensors

Self Cite

View full text Add to dashboard Cite

Composites of tetracycline (Tc)-imprinted polymethacrylates and quantum dots have been coated on chemically pretreated polyimide substrates (PIs) as fluorescent sensors. In this study, PIs were pretreated by capacitively coupled plasma (CCP) before coating the same composites on them. For the first time, to fabricate sensors by plasma modification of PIs, the CCP conditions, including plasma gas, flow rate, radio frequency generation power, and duration time, the fabrication details, including coating, baking, and stripping steps, and the sample loading process were optimized to perform a linear decrease in fluorescent intensity with Tc concentrations in the range of 5.0–3000 μM (R2 = 0.9995) with a limit of detection of 0.2 μM (S/N = 3, relative standard deviation (RSD) = 2.2%). The selectivity of the stripped PIs was evaluated by the imprinting factors (IFs) for Tc (IF = 7.2), other Tc analogues (IF = 3.4–5.3), and steroids (IF ≈ 1) and by the recoveries of 5.0 μM Tc from bovine serum albumin at 300 μg∙mL−1 (98%, RSD = 3.2%), fetal bovine serum at 1.5 ppt (98%, RSD = 2.8%), and liquid milk (94.5%, RSD = 5.3%). The superiority of the present plasma-treated-based sensor over the previous chemically-treated one in fabrication efficiency and detection effectiveness was clear.

show abstract

“…MIPs have been grafted onto the surface of magnetic nanoparticles, resulting in magnetic MIPs which possess both magnetically susceptible characteristics and good selectivity for the target molecules [19][20][21]. Fluorescent molecules such as fluorescent dyes, quantum dots or carbon dots have also been integrated into MIPs, which effectively turns the MIP composites into fluorescence-based sensors [22,23]. Several reports have even demonstrated the combined use of magnetic nanoparticles and fluorophores with MIPs [24,25].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the incorporation of fluorescence dyes or quantum dots into the MIP layer might lead to interference in MIP binding. Some work tried to avoid the problem by incorporating quantum dots into a separate silica layer, but this could in turn result in decrease in quenching ability due to the distance between the binding site and fluorescent molecules [22].…”

Section: Introductionmentioning

confidence: 99%

A multifunctional molecularly imprinted polymer-based biosensor for direct detection of doxycycline in food samples

Ashley

Feng

Sun

2018

Talanta

View full text Add to dashboard Cite

In this study, we developed a new type of multifunctional molecularly imprinted polymer (MIP) composite as an all-in-one biosensor for the low-cost, rapid and sensitive detection of doxycycline in pig plasma. The MIP composite consisted of a magnetic core for ease of manipulation, and a shell of fluorescent MIPs for selective recognition of doxycycline. By simply incorporating a small amount of fluorescent monomer (fluorescein-O-acrylate), the fluorescent MIP layer was successfully grafted onto the magnetic core via a surface imprinting technique. The resultant MIP composites showed significant doxycycline-dependent fluorescence quenching in an aqueous environment. Good linearity ranging from 0.2 to 6 µM was achieved, and the limit of detection was determined to be 117 nM. The biosensor also showed good selectivity towards doxycycline when compared to other common antibiotic residues. The multifunctional MIP composites were used to directly extract doxycycline from spiked pig plasma samples and quantify the antibiotics based on the quenched fluorescence signals. Recoveries of doxycycline were found in the range of 88-107%.

show abstract

Determination of tetracycline using imprinted polymethacrylates along with fluorescent CdTe quantum dots on plastic substrates

Cited by 30 publications

References 30 publications

Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis

Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis

Effective and Efficient Pretreatment of Polyimide Substrates by Capacitively Coupled Plasma for Coating the Composites of Tetracycline-Imprinted Polymers and Quantum Dots: Comparison with Chemical Pretreatment

A multifunctional molecularly imprinted polymer-based biosensor for direct detection of doxycycline in food samples

Contact Info

Product

Resources

About