Determination of the absolute configuration of (+)- and (−)-N-CBZ-3-fluoropyrrolidine-3-methanol using vibrational circular dichroism and confirmation of stereochemistry by conversion to (R)-tert-butyl 3-fluoro-3-(((R)-1-phenylethyl)carbamoyl)pyrrolidine-1-carboxylate

Absolute Configurations of Synthetic Molecular Scaffolds from Vibrational CD Spectroscopy

“…Further examples are propellane 34 (which may be considered axially chiral as well), the building block for α v β 6 integrin inhibitors 35 , the products of the anodic oxidation of 2,4-dimethylphenol such as 36 , the bioactive spiropyrazolone derivatives 37 , and the lactone 38 . Stoltz and co-workers investigated the enantioselective Pd-catalyzed allylic alkylation yielding dialkylated N-heterocycles such as 39 and utilized VCD spectroscopy to determine the AC of several of the obtained products …”

Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors

“…66 Exploring the utility of new methodology devised in a project and its exemplification with nonconfidential substrates allows much earlier publication of the science, but these experiments have to be fitted in around project work. 41,49,51,53 This can be achieved by working a little longer at the bench and by asking colleagues to help, with the promise that they will be considered for authorship in any forthcoming publication. This is a successful approach our experience, and colleagues may bring additional ideas and concepts that embellish the science.…”

“…Synthetic and methodology chemistry papers are generally much easier to write when compared to medicinal chemistry articles since there are typically fewer factors involved and the studies may be more succinct in scope. They cover a range of topics including correcting errors in the literature, , interesting rearrangements, − developing new reactions and devising new methodology, − detailed mechanistic studies, proof of stereochemistry, , and the characterization of natural products (although these are currently out of favor as sources of new leads for therapeutics) . Exploring the utility of new methodology devised in a project and its exemplification with nonconfidential substrates allows much earlier publication of the science, but these experiments have to be fitted in around project work. ,,, This can be achieved by working a little longer at the bench and by asking colleagues to help, with the promise that they will be considered for authorship in any forthcoming publication.…”

“…They cover a range of topics including correcting errors in the literature, , interesting rearrangements, − developing new reactions and devising new methodology, − detailed mechanistic studies, proof of stereochemistry, , and the characterization of natural products (although these are currently out of favor as sources of new leads for therapeutics) . Exploring the utility of new methodology devised in a project and its exemplification with nonconfidential substrates allows much earlier publication of the science, but these experiments have to be fitted in around project work. ,,, This can be achieved by working a little longer at the bench and by asking colleagues to help, with the promise that they will be considered for authorship in any forthcoming publication. This is a successful approach in our experience, and colleagues may bring additional ideas and concepts that embellish the science.…”