Determination of the Amount of Certain Heavy Metal Ions and Some Specific Liver Enzymes and Levels of Testesterone Hormone in the Blood Sera of Heavy Asphalt Workers and Rural Community in Van, Turkey

Atasoy, Nurhayat; Kanat, Yeliz

doi:10.3923/rjmsci.2011.73.79

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…We also noted significantly higher AST level between the study and control groups, in contrast to the findings of (Atasoy et al) [28]. The contradictory observations between these two studies could be explained by difference in the type of asphalt used, or the method of use and the extend and level of exposure to PAHs.…”

Section: Discussioncontrasting

confidence: 86%

Detection of Benzo[a] pyrenediol epoxide-DNA adducts in White Blood Cells of Asphalt Plant Workers in Syria

Zohairee¹,

Zamrik²,

Barguil³

2018

Rese. Jour. of Pharm. and Technol.

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Benzo[a]pyrene (B[a]P) is a major polycyclic aromatic hydrocarbon (PAH), it can bind the DNA to produce DNA-adducts, which has major carcinogenic potential. Enzyme-linked immunosorbet assay (ELISA) is the method used to detect these DNA adducts of B[a] P diolepoxide (BPDE) within the living cells.The aim of this study is to evaluate exposure to bitumen fumes, and to B[a]P in asphalt plant workers by measuring the BPDE-DNA adducts in their peripheral white blood cells (WBC), which are considered biological markers for exposure risk assessment. In this study, Hemostatic blood (CBC, AST) were measured, and the levels of BPDE-DNA adducts were measured in DNA samples of WBC obtained from asphalt plant workers in Syria and compared to those measured from a control group. The measurement was performed using BPDE-DNA Adducts ELISA.kit. The sample size was determined to be 50 with 25 asphalt plant workers and 25 healthy volunteers with no occupational exposure to PAHs.The results showed some diseases associated with exposure to asphalt fumes among the workers in the study group and a statistically significant difference in the values of (CBC; WBC, leukocytes, HCT, MCHC and AST) between the study group and the control group. BPDE-DNA adducts were detected in WBC of 11 asphalt plant workers with concentrations ranging between 0 and 2.75 ng/ml and only one individual in the control group with concentration of 0.75 ng/ml. These results indicate significant positive relationship between exposure to the bitumen fumes and formation of BPDE-DNA adducts.BPDE-DNA adducts is potential biomarker for PAHs exposure and likely helpful indicator of PAH-induced DNA damage and possibly carcinogenesis.

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Section: Discussioncontrasting

confidence: 86%

Detection of Benzo[a] pyrenediol epoxide-DNA adducts in White Blood Cells of Asphalt Plant Workers in Syria

Zohairee¹,

Zamrik²,

Barguil³

2018

Rese. Jour. of Pharm. and Technol.

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“…Most commonly, this would take the form of inhaled occupational dusts with the ability to adsorb trace elements from cigarette smoke. Further evidence for this compound exposure is demonstrated in Turkish bitumen ashphalters, who demonstrated a six-fold increase in serum cadmium compared to either non-smoking colleagues or control smokers [ 88 ] (Fig. 5 ).…”

Section: Pathophysiologic Considerations Of Vapour Gas Dust and Fumementioning

confidence: 96%

“… Interaction of asphalt exposure and cigarette smoking on serum cadmium levels among Turkish asphalt workers, adapted from Atasoy et al . [ 88 ]. …”

Section: Fig (1)mentioning

confidence: 99%

Is Male Rheumatoid Arthritis an Occupational Disease? A Review

Hutchinson

2017

TORJ

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Background:Rheumatoid arthritis (RA) is a systemic, inflammatory disease with an estimated global prevalence of 0.3–1.0%. An unexplained association exists between low formal education and the development of RA independent of smoking. It is established that RA is initiated in the lungs and that various occupations associated with dust, fume and metal inhalation can increase the risk of RA development.Objective:The objective of this review is to evaluate published clinical reports related to occupations associated with RA development. We highlight the concept of a “double-hit” phenomenon involving adsorption of toxic metals from cigarette smoke by dust residing in the lung as a result of various work exposures. We discuss the relevant pathophysiological consequences of these inhalational exposures in relation to RA associated autoantibody production.Method:A thorough literature search was performed using available databases including Pubmed, Embase, and Cochrane database to cover all relative reports, using combinations of keywords: rheumatoid arthritis, rheumatoid factor, anti-citrullinated peptide antibody silica, dust, fumes, metals, cadmium, cigarette smoking, asbestos, mining, bronchial associated lymphoid tissue, heat shock protein 70, and adsorption.Conclusion:We postulate that the inhalation of dust, metals and fumes is a significant trigger factor for RA development in male patients and that male RA should be considered an occupational disease. To the best of our knowledge, this is the first review of occupations as a risk factor for RA in relation to the potential underlying pathophysiology.

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“…We suggest occupational kaolin dust inhalation has resulted in the significantly raised urinary cadmium level reported here. men asphalters: Smokers demonstrated a six-fold increase in serum cadmium compared to either non-smoking colleagues or control smokers [12]. Further evidence is seen in an animal model.…”

Section: Case Reportmentioning

confidence: 89%

Rheumatoid Pulmonary Nodules and Significantly Elevated Urinary Cadmium in a Kaolin (China Clay) Worker: Could Cadmium Adsorption onto Occupationally Inhaled Dust Explain Caplan's Syndrome?

Dl¹,

Robert²,

Chris³

et al. 2017

J Rheum Dis Treat

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Determination of the Amount of Certain Heavy Metal Ions and Some Specific Liver Enzymes and Levels of Testesterone Hormone in the Blood Sera of Heavy Asphalt Workers and Rural Community in Van, Turkey

Cited by 7 publications

References 9 publications

Detection of Benzo[a] pyrenediol epoxide-DNA adducts in White Blood Cells of Asphalt Plant Workers in Syria

Detection of Benzo[a] pyrenediol epoxide-DNA adducts in White Blood Cells of Asphalt Plant Workers in Syria

Is Male Rheumatoid Arthritis an Occupational Disease? A Review

Rheumatoid Pulmonary Nodules and Significantly Elevated Urinary Cadmium in a Kaolin (China Clay) Worker: Could Cadmium Adsorption onto Occupationally Inhaled Dust Explain Caplan's Syndrome?

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