Determination of the antioxidant and enzyme-inhibiting activities and evaluation of selected terpenes' ADMET properties: in vitro and in silico approaches

Touhtouh, Jihane; Laghmari, Mustapha; Benali, Taoufiq; Aanniz, Tarik; Lemhadri, Ahmed; Akhazzane, Mohamed; Habbadi, Khaoula; Bouyahya, Abdelhakim; Zengin, Gokhan; Hammani, Khalil

doi:10.1016/j.bse.2023.104733

Cited by 7 publications

(2 citation statements)

References 72 publications

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“…In the DPPH assay, the mechanism of action involves measuring the free radical scavenging activity of the examined extracts by reducing the DPPH • radical to its non-radical form, DPPH-H [ 39 ]. Conversely, the ABTS test primarily relies on the chemical interaction between specific antioxidant molecules and the ABTS radical cation (ABTS •+ ).…”

Section: Resultsmentioning

confidence: 99%

Petroselinum crispum L., essential oil as promising source of bioactive compounds, antioxidant, antimicrobial activities: In vitro and in silico predictions

Nouioura,

El fadili,

El Hachlafi

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Petroselinum crispum L., essential oil as promising source of bioactive compounds, antioxidant, antimicrobial activities: In vitro and in silico predictions

Nouioura,

El fadili,

El Hachlafi

et al. 2024

Heliyon

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“…Due to their intense smell, monoterpenes are widely used in many industrial fields such as spices, cosmetics, flavors, etc. Nevertheless, most studies are based on their biological activities such as anticancer, antibacterial, and antifungal that reveal cardiovascular protective properties and are used in pharmacology and medicine [2]. The secondary plant metabolites are often considered as active anti-neurodegenerative natural compounds which are able to counteract a few neurodegenerative factors [3].…”

Section: Introductionmentioning

confidence: 99%

Ability of Selected Monoterpenes to Reduce Fe(III) Ions Being Pro-Neurodegenerative Factors: Tests Based on a FRAP Reaction Extended to 48 Hours

Wojtunik-Kulesza,

Oniszczuk

2024

IJMS

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Monoterpenes are secondary plant metabolites, and such volatile compounds have antioxidant, antibacterial, antiviral, and enzyme inhibitory properties. These compounds are also able to reduce the potentially pro-neurodegenerative trace metal ions that can be sources of free radicals. One basic method used to evaluate the ability of chemical compounds to reduce Fe(III) is FRAP. To date, most studies based on a FRAP assay were performed within several dozen minutes. However, taking into account the diversity of compounds, it is justified to observe their activity over a much longer period of time. The present study aimed to observe the activity of isopulegol, γ-terpinene, α-terpinene, linalool, carvone, citral, and α-phellandrene over a 48 h period. Our study indicates that the lengthened reaction period enhanced activity from several dozen to several hundred percent. The obtained results also revealed an explicit high correlation of the increase in the activity of compounds with the increase in monoterpene concentration. Due to the hydrophobic character of monoterpenes, the FRAP method was modified by the addition of Tween 20. The highest activity was obtained for α-terpinene and γ-terpinene.

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Initial report on the multiple biological and pharmacological properties of hispolon: Exploring stochastic mechanisms

Aanniz,

Zeouk,

Elouafy

et al. 2024

Biomedicine & Pharmacotherapy

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Determination of the antioxidant and enzyme-inhibiting activities and evaluation of selected terpenes' ADMET properties: in vitro and in silico approaches

Cited by 7 publications

References 72 publications

Petroselinum crispum L., essential oil as promising source of bioactive compounds, antioxidant, antimicrobial activities: In vitro and in silico predictions

Petroselinum crispum L., essential oil as promising source of bioactive compounds, antioxidant, antimicrobial activities: In vitro and in silico predictions

Ability of Selected Monoterpenes to Reduce Fe(III) Ions Being Pro-Neurodegenerative Factors: Tests Based on a FRAP Reaction Extended to 48 Hours

Initial report on the multiple biological and pharmacological properties of hispolon: Exploring stochastic mechanisms

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