Determination of the axial and circumferential mechanical properties of the skin tissue using experimental testing and constitutive modeling

Karimi, Alireza; Navidbakhsh, Mahdi; Haghighatnama, Maedeh; Haghi, Afsaneh Motevalli

doi:10.1080/10255842.2014.961441

Cited by 28 publications

(15 citation statements)

References 59 publications

(42 reference statements)

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“…There have been some reports on the measurement of the mechanical properties of the rat and mice skin tissues using uniaxial 18,26 or biaxial 27,28 tensile tests. However, so far no study has investigated the anisotropic mechanical properties of the rat and mice skin tissues at different anatomical locations of their body, i.e., abdomen and back, using histostructural and uniaxial extension data.…”

Section: Discussionmentioning

confidence: 99%

“…However, so far no study has investigated the anisotropic mechanical properties of the rat and mice skin tissues at different anatomical locations of their body, i.e., abdomen and back, using histostructural and uniaxial extension data. There have been some studies which used Ogden, 18 Neo-Hookean, 17 Mooney-Rivlin, 26 and Fung-type 29,30 material model to address the nonlinear mechanical behavior of the skin tissue. However, none of those studies implemented the role of fiber orientations into a constitutive equation to capture the anisotropic nonlinear mechanical properties of the skin tissue.…”

Section: Discussionmentioning

confidence: 99%

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Mechanical characterization of the rat and mice skin tissues using histostructural and uniaxial data

2015

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The skin tissue has been shown to behave like a nonlinear anisotropic material. This study was aimed to employ a constitutive fiber family equation to characterize the nonlinear anisotropic mechanical behavior of the rat and mice skin tissues in different anatomical locations, including the abdomen and back, using histostructural and uniaxial data. The rat and mice skin tissues were excised from the animals' body and then the histological analyses were performed on each skin type to determine the mean fiber orientation angle. Afterward, the preconditioned skin tissues were subjected to a series of quasi-static axial and circumferential loads until the incidence of failure. The crucial role of fiber orientation was explicitly added into a proposed strain energy density function. The material coefficients were determined using the constrained nonlinear optimization method based on the axial and circumferential extension data of the rat and mice samples at different anatomical locations. The material coefficients of the skins were given with R 2 0.998. The results revealed a significant load-bearing capacity and stiffness of the rat abdomen compared to the rat back tissues. In addition, the mice abdomen showed a higher stiffness in the axial direction in comparison with circumferential one, while the mice back displayed its highest stiffness in the circumferential direction. The material coefficients of the rat and mice skin tissues were determined and well compared to the experimental data. The optimized fiber angles were also compared to the experimental histological data, and in all cases less than 11.85% differences were observed in both the skin tissues.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mechanical characterization of the rat and mice skin tissues using histostructural and uniaxial data

2015

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“…2) resulted to have a high variability, and demonstrated the pronounced anisotropy of the tissue, since CC and the ML directions have produced very different responses; as a consequence, anisotropic hyper-elastic material models were expected to be more adequate to reproduce dermis response. Two anisotropic hyper-elastic constitutive laws were selected, which had been developed for modelling arterial walls but can be adapted to any soft tissue, together with an isotropic hyper-elastic model which still finds application in soft tissues modelling [10], [19]. The isotropic Ogden model strain energy function presents as follows:…”

Section: Experimental Biaxial Datamentioning

confidence: 99%

“…Numerical methods applied to soft biological tissues have considerably spread recently, and, as a consequence, hyper-elastic anisotropic constitutive formulations have been implemented in commercial FE codes. Although nonlinear isotropic material models such as the Ogden, Mooney-Rivlin and Neo-Hookean ones have been used to describe the mechanical response of skin [9], [10], [19], more adequate anisotropic structural formulations, i.e. accounting for the real collagenous structure of soft tissues, have recently been developed [7], [15], [16], [20], [21], which more coherently represent their mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

A Constitutive Framework for Human Dermis Mechanical Modelling

Aldieri¹,

Terzini²,

Bignardi³

et al. 2017

WIT Transactions on Engineering Sciences

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Finite element models, in conjunction with adequate constitutive relations of the materials involved, have proved to be crucial in many medical applications, such as in surgical planning. Nevertheless, a thorough numerical analysis of dermis' mechanical response is a challenging research area because of dermis' highly anisotropic and nonlinear behaviour. The aim of this work has been to assess the performance of two orthotropic and one isotropic hyper-elastic constitutive laws, providing an experimental-computational framework for the definition of reliable constitutive models of dermis tissue. Experimental, equi-biaxial stress-strain data obtained on human reticular dermis specimens have been exploited in order to extract, through a stochastic optimization procedure, constitutive parameters of three widely used constitutive laws: the Ogden, Holzapfel and Gasser-Ogden-Holzapfel (GOH) models. A set of specimen specific parameters and a set of best matching parameters, determined by simultaneously fitting all experimental stress-strain curves, have been obtained. The goodness of the selected laws has been assessed by means of FEM simulations performed in Abaqus (Simulia, Dessault Systèmes Inc.) which reproduce the actual specimen boundary conditions and geometry, rebuilt through an image segmentation process implemented in MATLAB (The MathWorks, Inc.). Models have been validated comparing experimental and numerical outcomes related to reference points on the specimen surface. In the preliminary fitting phase, Normalized Root Mean Square Error values were above 0.9 for the specimen-specific and above 0.54 for the best matching models. The comparison between numerical and experimental outcomes has highlighted the inadequacy of the isotropic constitutive law in reproducing the dermis behaviour, particularly at higher stretch levels. Errors obtained in the horizontal loading direction are lower than 40% for Holzapfel and GOH models, while the Ogden model reaches the 80%. Lower and more uniform errors occur in the orthogonal direction, which settles below 30% for the orthotropic laws, while it increases up to 40% in the isotropic case.

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“…Measurements on ex vivo animal skin were performed abundantly, mostly in uniaxial (Groves et al, 2013;Li and Xiaoyu, 2016;Lokshin and Lanir, 2009a;Bischoff, 2006;Karimi et al, 2015Karimi et al, , 2016Limbert, 2011) tests and a single multiaxial (Jor et al, 2011) tensile test. However, because of the well-known anatomical, biological and mechanical differences, it is difficult to translate these results to human skin.…”

Section: Introductionmentioning

confidence: 99%

A model of human skin under large amplitude oscillatory shear

Soetens

Vijven

Bader

et al. 2018

Journal of the Mechanical Behavior of Biomedical Materials

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A B S T R A C TSkin mechanics is of importance in various fields of research when accurate predictions of the mechanical response of skin is essential. This study aims to develop a new constitutive model for human skin that is capable of describing the heterogeneous, nonlinear viscoelastic mechanical response of human skin under shear deformation. This complex mechanical response was determined by performing large amplitude oscillatory shear (LAOS) experiments on ex vivo human skin samples. It was combined with digital image correlation (DIC) on the cross-sectional area to assess heterogeneity. The skin is modeled as a one-dimensional layered structure, with every sublayer behaving as a nonlinear viscoelastic material. Heterogeneity is implemented by varying the stiffness with skin depth. Using an iterative parameter estimation method all model parameters were optimized simultaneously. The model accurately captures strain stiffening, shear thinning, softening effect and nonlinear viscous dissipation, as experimentally observed in the mechanical response to LAOS. The heterogeneous properties described by the model were in good agreement with the experimental DIC results. The presented mathematical description forms the basis for a future constitutive model definition that, by implementation in a finite element method, has the capability of describing the full 3D mechanical behavior of human skin.

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Determination of the axial and circumferential mechanical properties of the skin tissue using experimental testing and constitutive modeling

Cited by 28 publications

References 59 publications

Mechanical characterization of the rat and mice skin tissues using histostructural and uniaxial data

Mechanical characterization of the rat and mice skin tissues using histostructural and uniaxial data

A Constitutive Framework for Human Dermis Mechanical Modelling

A model of human skin under large amplitude oscillatory shear

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