Determination of the Bacteriocin-like Substances Produced By Enterococcus hirae Isolated from Traditional Egyptian Food (Koskos)

Azab, Essam A.; Elsilk, Sobhy E.; El-Salam, Ibrahim S. Abd; Tahwash, Amal M.

doi:10.13005/bbra/2100

Cited by 1 publication

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The in vivo assessment of bacteriocins in alternative models has been evaluated using a CFS that contains a bacteriocin like-substance (BLIS). For example, A. salina brine shrimp showed no toxicity of CFS with BLIS from Enterococcus hirae ( Azab et al, 2016 ). Recently, CFS from Lactobacillus curvatus P99 cultures showed no toxic effect in D. melanogaster flies ( Funck et al, 2019 ).…”

Section: In Vivo Assessment Of Bacteriocinsmentioning

confidence: 99%

Bacteriocins: An Overview of Antimicrobial, Toxicity, and Biosafety Assessment by in vivo Models

et al. 2021

View full text Add to dashboard Cite

The world is facing a significant increase in infections caused by drug-resistant infectious agents. In response, various strategies have been recently explored to treat them, including the development of bacteriocins. Bacteriocins are a group of antimicrobial peptides produced by bacteria, capable of controlling clinically relevant susceptible and drug-resistant bacteria. Bacteriocins have been studied to be able to modify and improve their physicochemical properties, pharmacological effects, and biosafety. This manuscript focuses on the research being developed on the biosafety of bacteriocins, which is a topic that has not been addressed extensively in previous reviews. This work discusses the studies that have tested the effect of bacteriocins against pathogens and assess their toxicity using in vivo models, including murine and other alternative animal models. Thus, this work concludes the urgency to increase and advance the in vivo models that both assess the efficacy of bacteriocins as antimicrobial agents and evaluate possible toxicity and side effects, which are key factors to determine their success as potential therapeutic agents in the fight against infections caused by multidrug-resistant microorganisms.

show abstract

Section: In Vivo Assessment Of Bacteriocinsmentioning

confidence: 99%