Determination of the binding site of chloro(triethylphosphine)gold(I) in serum albumin

Sułkowska, Anna; Sułkowski, Wieslaw W.; Nowak, Krzysztof; Pentak, Danuta; Maciążek-Jurczyk, Małgorzata; Równicka-Zubik, J.

doi:10.1016/j.molstruc.2010.02.053

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2019

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Cited by 2 publications

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“…The best SI values for Ph3P-Au-tuH complex were found for the glioma (U251, SI = 4.07), renal (786-0, SI = 2.65) and leukemia lines (K-562, SI = 24.4). According to the literature, the chlorido(triphenylphosphine)gold(I) (Ph3P-Au-Cl) compound is able to induce apoptosis in breast tumor cells (MCF-7) with low level of ct-DNA interaction, and Ph3P-Au-Cl interacts with sulphydryl groups present in serum albumin (BSA) [145]. These activities could partially explain the antiproliferative effect observed for Ph3P-Au-Cl.…”

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confidence: 99%