Experimental data and theoretical results on charge loss −27ഛ⌬Z ഛ −1, charge pickup ⌬Z = + 1, and total charge-changing cross sections for 158A GeV 82 208 Pb ions on CH 2 , C, Al, Cu, Sn, and Au targets are presented.Calculations based on the revisited abrasion-ablation model for hadronic interaction and the relativistic electromagnetic dissociation (RELDIS) model for electromagnetic interaction describe the data. The decay of excited nuclear systems created in both types of interaction is described by the statistical multifragmentation model (SMM), which includes evaporation, fission, and multifragmentation channels. We show that at very high projectile energy the excitation energy of residual nuclei may be described on average as ϳ40 MeV per removed nucleon, with some increase in this value compared to fragmentation of intermediate energy heavy ions at ϳ1A GeV. The importance of the electromagnetic interaction in production of 80 Hg, 81 Tl, and 83 Bi projectile fragments on heavy targets is shown. A strong increase of nuclear-charge pickup cross sections, forming 83 Bi, is observed in comparison to similar measurements at 10.6A GeV. This process is attributed to the electromagnetic production of a negative pion by an equivalent photon, which is quantitatively described by the RELDIS model.