Determination of the disintegration behavior of magnetically marked tablets

A Semi-mechanistic Modeling Strategy to Link In Vitro and In Vivo Drug Release for Modified Release Formulations

“…Formulation Z was also investigated with the modified ERWEKA (m-ERWEKA) dissolution tester (21). The USP 2 experiments were carried out at AstraZeneca R&D, Mölndal Sweden and the m-ERWEKA experiments in Institute of Pharmacy, University of Greifswald, Greifswald, Germany.…”

“…A mathematical relationship between the decrease in magnetical signal and amount of released drug substance was derived based on in vitro characterization of the labeled formulation (21). Using this correlation function and the individually measured magnetic moments the theoretical amount of drug remaining to be released at each time point could be calculated.…”

“…For dosage forms where the drug release rate is determined by the erosion of the dosage form, the magnetic moment can be linked to the drug release. In these cases a relationship between decrease in magnetic signal and drug release characterized in in vitro experiments can be used to obtain actual in vivo drug release profiles (21).…”

Biomagnetic Methods: Technologies Applied to Pharmaceutical Research

“…Alternatively, the disintegration process of magnetically marked tablets in relation to the temporal development of the magnetic moments also can be investigated (90). In this case, the magnetic moments of the particles are aligned during magnetization into the direction of the magnetic field applied.…”

“…The disintegration process of tablets and capsules can be accurately determined in vitro (90,97). While the dosage form is characterized as a marker, the magnetic dipole moment remains stable; however, when the release of magnetic particles from the dosage forms occurs, those particles lose their orientation and do not generate a background signal; therefore, the time course of the magnetic moment is the direct measurement of disintegration (Fig.…”