The paper investigates the effect of silver nanoparticles preparations on the
rate of burn healing and scar quality. Three preparations on burn were
considered: one with silver sulfadiazine and two with silver nanoparticles
woven into two types of dressing: one, of polyethylene and second,
carboxymethyl cellulose. The experiment was performed on pigs, due to
anatomical and pathophysiological similarities with human skin. All three
silver preparations have antimicrobial properties with a beneficial effect
on the healing of burns. Preparations with silver nanoparticles proved to be
the most effective, since they encourage very fast epithelialization of
burns, affect reduction of the level of matrix metalloproteinase-9 in the
environment of the burn wound, lead to faster expression of Vascular
Endothetial Growth Factor - VEGF, cause less thickening of the epidermis and
contractility, and improve tension characteristics of the scar compared to
the preparation with silver sulfadiazine. By comparing results of healing
parameters and evaluation of the scar achieved with preparations with silver
nanoparticles, it was determined that the best overall results of local
treatment were achieved with silver nanoparticles in crystalline form. Due
to quantum-mechanics, surface and chemical oxidation-reduction (reactive
oxygen species) phenomenological characteristics Ag nanoparticles in
crystalline form have unique ability to catalyze rate of healing.