Determination of the Flow Parameters of a Scattering Liquid in a Microfluidic Blood Vessel Phantom Based on Laser Speckle Contrast Imaging

Galyastov, Andrey; Stavtsev, D. D.; Kozlov, Igor; Konovalov, A N; Gerasimenko, Alexander Yu.; Telyshev, D. V.

doi:10.1007/s10527-023-10283-x

Biomed Eng

2023

DOI: 10.1007/s10527-023-10283-x

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Determination of the Flow Parameters of a Scattering Liquid in a Microfluidic Blood Vessel Phantom Based on Laser Speckle Contrast Imaging

Andrey Galyastov

D. D. Stavtsev

Igor Kozlov

et al.

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2024

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Laser speckle imaging of the hippocampus

Mikkelsen,

Skøtt,

Gutierrez

et al. 2024

Biomed. Opt. Express

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Research on hippocampal blood flow is essential for gaining insight into its involvement in learning and memory and its role in age-related cognitive impairment and dementia. In this study, we applied laser speckle contrast imaging (LSCI) and dynamic light scattering imaging (DLSI) to monitor perfusion in mouse hippocampus via a chronic, optically transparent window. LSCI scans showed hippocampal blood vessels appear more out of focus than similar caliber vessels in the mouse cortex. We hypothesize that it is caused by the inverse vascular topology and increased contribution of multiply-scattered photons detected from the upper layers of the hippocampus. We support the hypothesis with DLSI, showing a 1300% increased contribution of multiple-scattering unordered dynamics regime in large hippocampal vessels.

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Laser speckle imaging of the hippocampus

Mikkelsen,

Skøtt,

Gutierrez

et al. 2024

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

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Determination of the Flow Parameters of a Scattering Liquid in a Microfluidic Blood Vessel Phantom Based on Laser Speckle Contrast Imaging

Cited by 1 publication

References 13 publications

Laser speckle imaging of the hippocampus

Laser speckle imaging of the hippocampus

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