Determination of the Impact of the Compression Force by Evaluating the Mechanical and Release Properties of Mesalazine Tablets

Abstract

Drug delivery to the targeted site of action in the human body is always affected by the excipients used and almost in the same manner by some processing variables like changes in the compression force. The aim of this study was to investigate the impact of the changes in compression forces during tablet manufacturing on the mechanical and release properties of mesalazine matrix tablets. For the mechanical properties, hardness and friability were used as assessment properties, while dissolution test was undertaken in order to ascertain the release properties. Data were analysed using One-way ANOVA at p < 0.05. The tablet hardness and friability were typically compression pressure-dependent with a significant difference in tablet hardness and friability with the increase in compression pressure (p < 0.001). The release properties of mesalazine tablets were not significantly influenced by compression pressure but rather by the polymer and the material properties of the drug. RezumatCedarea țintită a substanței medicamentoase din forma farmaceutică este aproape întotdeauna influențată de prezența excipienților, dar și de variabile ce intervin în procesul de obținere al acestora, cum ar fi forța de comprimare. Scopul studiului a fost de a investiga impactul modificărilor forței de comprimare în procesul de comprimare asupra proprităților mecanice și de cedare a mesalazinei din comprimate. Pentru proprietățile mecanice, au fost investigate rezistența comprimatului la rupere și friabilitatea, iar în cazul proprietăților de cedare, au fost efectuate teste de dizolvare. Datele au fost analizate prin intermediul analizei unifactoriale de varianță ANOVA, stabilind p < 0,05 ca având semnificație statistică. Rezistența la rupere și friabilitatea depind într-o manieră proporțională de forța de comprimare (p < 0,001). Forța de comprimare nu a influențat proprietățile de cedare ale mesalazinei din comprimate, acestea fiind modificate de matrița polimerică și de componentele materiale ale comprimatelor.

Formulation and Optimization of Matrix Tablets Based on Spirulina and Vitamin C

“…Since the dissolution rate is also a function of the disintegration time of the tablets, we noticed a more coordinated and time-dependent (sustained) release of vitamin C from the spirulina + vitamin C tablets. These results are similar to those of Saurav A. et al, who found that good sized particles give more compact matrices, which slows down the dissolution rate of the active ingredient 15 . A prior granulation operation of the powder of formula A1 can improve its flow and its compressibility and will make it possible to obtain a firmer matrix which will slow down the rate of release of vitamin C.…”

“…The slight resistance of vitamin C tablets associated with spirulina could be explained by a better cohesion of the particles in the powder containing spirulina. Catalin D. et al, also demonstrated the influence of compression force, particle size and shape on tablets strength 15 . These parameters can be corrected by operations prior to compression such as the granulation and spheronization 14 .…”

“…These parameters can be corrected by operations prior to compression such as the granulation and spheronization 14 . Furthermore, Saurav A. et al, proved that wet granulation applied to HPMC powder gives much more compact tablets 15 .…”