Determination of the individual specific heat capacities of solids from multi-component powder mixtures and polymorphic mixtures

Tjahjono, Martin; Schreyer, Martin; Guo, Liangfeng; Garland, Marc

doi:10.1007/s10973-011-1928-4

Cited by 11 publications

(3 citation statements)

References 28 publications

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“…Thermal analysis is frequently utilized to swot up variation in properties of material with temperature. To confirm new crystal form or solid forms of pharmaceuticals, techniques viz., (i) powder X-ray diffraction experiment is performed in order to understand the measurement and structural characterization 10 and (ii) FT-IR, is used for the identification of salt or co-crystal 11 .…”

Section: Introductionmentioning

confidence: 99%

Novel Salt of Tinidazole with Improved Solubility and Antibacterial Activity

Patnala¹,

Mukkanti²,

Ram³

et al. 2017

Orient. J. Chem

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The present study describes the preparation of novel salt of Tinidazole (TN) with p-Toluenesulfonic acid (PTSA) that display enhanced solubility and antibacterial activity in Bacillus. The salt was prepared by solvent-drop grinding and characterised by powdered X-Ray diffraction, thermal analysis, Fourier transformation infrared spectroscopy (FT-IR) and polarized microscopy. FT-IR data confirms Tinidazole salt with p-Toluenesulfonic acid (TN-PTSA). Powdered X-ray diffraction and thermal analysis data reveals that both TN and TN-PTSA are crystalline nature. From microscopic photographs of polarized microscopy, crystals of TN-PTSA are rod shape whereas crystals of TN are plate shape. Solubility measurement of TN-PTSA on UV spectrophotometer showed solubility improvement compared with TN by 49.7 times in water. Antibacterial test showed higher activity in TN-PTSA to the Gram-positive bacillus bacteria as compared to the TN. This study demonstrates that TN-PTSA can be a potential substitute to the TN in the treatment of infection with Gram-positive bacillus bacteria.

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Section: Introductionmentioning

confidence: 99%

Novel Salt of Tinidazole with Improved Solubility and Antibacterial Activity

Patnala¹,

Mukkanti²,

Ram³

et al. 2017

Orient. J. Chem

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show abstract

“…According to the heat balance equation (see Equation ( 8 )), density

, specific heat

, and thermal conductivity k must be provided. For the PP/HDPE blend, the empirical Neumann–Kopp law was adopted to provide the estimation of the density [ 41 , 42 ] and the heat capacity [ 43 , 44 ] for a mixed material, which are given by

where

is the weight fraction of each blending component.…”

Section: Thermomechanical Modelingmentioning

confidence: 99%

Advancing the Characterization of Recycled Polyolefin Blends with a Combined Experimental and Numerical Approach to Thermomechanical Behavior

Hao,

Siebers,

Ragaert

et al. 2024

Polymers

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The blending of polyolefins (POs), such as polyethylene (PE) and polypropylene (PP), is a growing area of research, particularly for recycling mixed polyolefin (MPO) waste through flotation sorting techniques. However, understanding the thermomechanical behavior of these recycled blends is challenging due to limitations in the existing characterization methods. This paper introduces a combined experimental and numerical method to accurately assess the complex mechanical behavior of high-density PE, PP, and their blends. We conducted detailed thermomechanical analyses using a high-speed stereo digital image correlation (DIC) system paired with an infrared camera to capture temperature variations alongside mechanical stress and strain. This approach allowed us to correct for distortions caused by necking and to derive accurate stress–strain relationships. We also applied a cutting-edge unified semi-crystalline polymer (USCP) model to simplify the analysis, focusing on the effects of strain rate and temperature, including self-heating and thermal softening phenomena. Our results, which closely match experimental observations of stress–strain behavior and temperature changes, offer new insights into the thermomechanical properties of PO blends, which are essential for advancing their practical applications in various fields.

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“…In order to confirm the formation of new solid forms of pharmaceuticals, powder X-ray diffraction measurements is used as an important tool for their structural characterization 15 . Confirmation of the formation of salt/molecular salts can be determined by PXRD and single crystal X-ray (or neutron) diffraction techniques [16][17][18][19][20][21] .Recently, we have reported the powder X-Ray diffraction patterns of the TN and TN-PTSA and confirmed that the powder diffraction pattern of TN-PTSA solid form is different from the XRD pattern of TN 6 .…”

Section: Powder X-ray Diffraction Analysismentioning

confidence: 99%

Synthesis, Characterization and Biological Activity of Novel Salt/Molecular Salts of Tinidazole

Patnala¹,

Mukkanti²,

Ram³

et al. 2017

Orient. J. Chem

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The present study is the continuation of our recently published work on novel salts of Tinidazole, in this study, new solid forms i.e salt/molecular salts of Tinidazole with certain selected organic acids such as hydroxyl benzoic acids, oxalic acid and para-toulenesulphonic acid (TN-organic acids) and inorganic acid such as hydrochloric acid (TN-HCl) were prepared and tested for the solubility parameter. The solubility of TN (compound 1) is 3.7 mg /mL, TN-HCl (compound 2) is 321.2 mg/mL and TN-PTSA (compound 3) is 184.2 mg /mL. These results clearly indicates enhancement of solubility by 86.8 folds and 49.7 folds respectively when compared to TN. These new solid phases (compounds 1-11) were characterized by IR, 1H NMR and DSC and were evaluated for various biological activities viz., anti-antibacterial, analgesic and anti-inflammatory activity. Compounds, TN-PTSA and TN-EBA exhibited good antibacterial activity against the Gram negative bacterial strain, Bacillus subtilus. In case of anti-inflammatory activity studies, TN-PTSA,TN-HCl,TN-DBA exhibited significant activity ranging from 45 to 50 % when compared to TN (50.7%) but exhibited moderate activity in comparison to the standard drug Diclofenac sodium (67.3%). While, in case of analgesic activity, TN-PBA, TN-PTSA, TN-VA exhibited prominent activity ranging from 78 to 86 % when compared to TN (94.1%) but exhibited moderate analgesic activity in comparison to the standard drug morphine (97.3%).

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Determination of the individual specific heat capacities of solids from multi-component powder mixtures and polymorphic mixtures

Cited by 11 publications

References 28 publications

Novel Salt of Tinidazole with Improved Solubility and Antibacterial Activity

Novel Salt of Tinidazole with Improved Solubility and Antibacterial Activity

Advancing the Characterization of Recycled Polyolefin Blends with a Combined Experimental and Numerical Approach to Thermomechanical Behavior

Synthesis, Characterization and Biological Activity of Novel Salt/Molecular Salts of Tinidazole

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