Determination of the interaction between glimepiride and hyperbranched polymers in solid dispersions

Synthesis of poly(ester-amide) dendrimers based on 2,2-Bis (hydroxymethyl) propanoic acid and glycine

“…On the contrary, the PVA proved to be ineffective. These results thus confirm the findings of our previous studies, which revealed that hydroxyl functional groups are not involved in complex formation between glimepiride and poly(ester‐amide) hyperbranched polymer …”

“…Our previous work revealed that poly(ester‐amide) hyperbranched polymers enhance water‐solubility of the poorly water‐soluble antidiabetic drug glimepiride by preparation of solid dispersions that were finally incorporated into the tablet formulation . Experimental results showed that the improved glimepiride solubility is due to the formation of a complex between the glimepiride drug and the hyperbranched polymer which is stabilized by a hydrogen‐bond interaction between the slightly acidic proton of NH group of the glimepiride sulfonylurea segment and the carbonyls of the amide and ester bonds of the hyperbranched polymers, while the hydroxyl groups did not seem to play a role in the complex formation . This interaction allows molecularly dispersed glimepiride within the amorphous hyperbranched polymers and thereby glimepiride solubility and dissolution rate are significantly improved.…”

Improvement in oral bioavailability and dissolution of tanshinone IIA by preparation of solid dispersions with porous silica

“…The others effects, such as hydrogen bonding between the silanol groups of silica and carbonyl groups of tanIIA were demonstrated using FTIR spectroscopy. Hydrogen‐bond formation could improve the wettability properties of the drug and further increase drug dissolution rates [39–41]…”

A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique

“…Concerning the drawbacks associated with the GLMP treatment, the use of suitable strategies to increase its water solubility or gastrointestinal absorption could reduce the undesirable side effects by the administration of lower doses (Aloisio et al, 2013). To overcome these obstacles, a lot of new pharmaceutical technologies, such as inclusion complexes (Ammar et al, 2006a,b), solid dispersions (Ahuja et al, 2007;Mohamed et al, 2012;Pahovnik et al, 2011), cosolvent (Seedher and Kanojia, 2009), self-nanoemulsifying system (Mohd et al, 2014;Shah et al, 2013), nanocrystal (Du et al, 2013;Ning et al, 2011), and micelles (Reven et al, 2010(Reven et al, , 2013Seedher and Kanojia, 2008) have been used for increasing the solubility of glimepiride. Although those technologies improved the solubility of glimepiride to some extent, the improvement of clinical efficacy was not clear or the complex preparation was not suitable for industrial production.…”