Determination of the macro- and microelement composition of the saliva of СHPP workers

Abstract

Chemical homeostasis is a necessary component of maintaining health, and an excessive or insufficient level of macro- and microelements in the body is considered as a risk factor for the development of pathological changes. Purpose of the study: to study the possibility of determining the micro- and macroelement composition of saliva by capillary electrophoresis, and to assess the applicability of the data for monitoring the technogenic load on the human body. Methods: For the experiment, we used saliva samples of employees of the Omsk СHPP aged 25-45 years (main group, n=104) and healthy volunteers aged 23-25 years who were not related to the СHРP (comparison group, n=195). In all samples, the content of potassium, sodium, magnesium, calcium, lithium, strontium, barium and magnesium was determined by capillary electrophoresis. In all samples, the content of potassium, sodium, magnesium, calcium, lithium, strontium, barium and magnesium was determined by capillary electrophoresis. Results: It has been established that potassium, sodium, magnesium and calcium ions were present in all the studied samples, however, their balance is significantly disturbed under conditions of technogenic pollution. It was shown that the frequency of occurrence of lithium, barium, strontium and manganese was significantly higher for СHPP workers compared to the control group. Strontium was not found in the saliva of volunteers in the control group; its appearance correlated with working conditions. Conclusions: The proposed method allows assessing the degree of technogenic load on the body and identifying a risk group for which it is necessary to select appropriate preventive measures and be more attentive to the diagnosis of occupational diseases as part of a planned medical examination.