Determination of the novel non-steroidal anti-inflammatory drug lornoxicam and its main metabolite in plasma and synovial fluid

Spectrofluorimetric and Spectrophotometric Stability-Indicating Methods for Determination of Some Oxicams Using 7-Chloro-4-nitrobenz-2-oxa-1,3-diazole (NBD-Cl)

“…2) Lx is not official in any pharmacopoeia and a literature survey revealed that few attempts have been made as stability indicating methods, spectrophotometric, 6) electrochemical 7) and few HPLC [8][9][10] methods were reported for its determination. For Tx, different methods were reported including spectrophotometric, 6,[11][12][13] fluorimetric, [13][14][15] infrared, 16) electrochemical [17][18][19] and HPLC 8,20) methods.…”

“…The volume was completed to the mark with distilled water. Standard working solutions (10,20,40,60,80, 100 mg ml Ϫ1 for Lx and Tx alkaline degradates, while 5, 10, 20, 30, 40 mg ml Ϫ1 for Mx alkaline degradate) were prepared by suitable dilution of the obtained stock solutions of standard degradates,these solutions were used for spectrophotometric method. For spectrofluorimetric method, the standard working solutions were further diluted ten times in 10-ml volumetric flasks.…”

“…Then the volume was completed to the mark with distilled water. Standard working solutions (10,20,40,60,80, 100 mg ml Ϫ1 for Lx and Tx while 5, 10, 20, 30, 40 mg ml Ϫ1 for Mx) were prepared by appropriate dilution with distilled water. These solutions were used for spectrophotometric method.…”

Comparative study on two rapid and sensitive methods for quantitative determination of tenoxicam in tablets

“…Several analytical methods are described in recent literature such as mass spectrometric (McKinney et al, 2004), spectrofluorometric (Taha et al, 2002;Barary et al, 2004), potentiometric (El-Ries et al, 2003), polarographic (Atkopar and Tuncel, 1996), infrared spectrophotometric (Atay and Dincol, 1997) [7], coulometric (Nikolic et al, 1993), spectrophotometric (Amin, 2002;Garcia et al, 1999;El-Ries, 1998;Yener, Topaloglu, 1992;El Walily et al, 1997), derivative spectrophotometric (Taha et al, 2003) and high performance liquid chromatographic techniques (Hye et al, 2005;Sultan, et al, 2005;Taha et al, 2004;Bartsch et al, 2002;Abdel-Hamid, 2000;JosephCharles and Bertucat, 1999;Radhofer-Welte, Dittrich, 1998;Walily et al, 1997;Tracqui et al, 1995;Mason and Hobbs, 1995;Munera-Jaramillo, Botero-Garces, 1993;Carlucci et al, 1992;Dixon et al, 1984).…”

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“…It has been found to be effective in inflammatory diseases of the joints, osteoarthritis, pain following surgery, and acute lumbar sciatica conditions, and for postoperative pain management 20 . In the literatures, a voltammetric 21 , polarograhic 22 , UV spectrophotmetric 23 , LC/MS/MS 24,25 , TLCdensitometry 26 and high performance liquid chromatographic [27][28][29][30][31] methods were reported for the analysis of Lornoxicam.…”