Determination of the parent of origin in nine cases of prenatally detected chromosome aberrations found after intracytoplasmic sperm injection

Opstal, Diane Van; Los, Frans J.; Ramlakhan, S.; Hemel, J. O. Van; Ouweland, Ans M.W. van den; Brandenburg, Helen; Pieters, M.H.E.C.; Verhoeff, Arie; Vermeer, M. C. S.; Dhont, Marc; Veld, Pieter In 'T

doi:10.1093/humrep/12.4.682

Cited by 121 publications

(61 citation statements)

References 12 publications

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“…The much higher incidences of chromosomal abnormalities after ICSI reported by In't Veld et al (1995) and Van Opstal et al (1997) are consistent with our data. Previously, Martin (1996) suggested that there may be a risk of transmitting chromosomal abnormalities to offspring following ICSI.…”

Section: Discussionsupporting

confidence: 93%

The high incidence of meiotic errors increases with decreased sperm count in severe male factor infertilities

Pang¹,

Kim²,

Lee³

et al. 2005

Human Reproduction

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BACKGROUND:The high frequency of aneuploidy sperm raises concerns that there may be an increased incidence of aneuploid offspring in ICSI programmes. In order to assess the role that chromosome complement plays in normal and abnormal fertility, detailed molecular cytogenetic studies must be done on sperm samples from men with normal and abnormal fertility. METHODS: To understand more clearly the cytogenetic make-up of sperm from oligoasthenoteratozoospermic (OAT) patients, multi-colour fluorescence in situ hybridization was used to determine numerical chromosome abnormalities. RESULTS: Increased aneuploidy frequencies for chromosomes 13, 18, 21, X and Y were detected in sperm from OAT patients. The frequencies of diploidy also increased. There were no differences in non-disjunction at meiosis I compared to meiosis II. Sperm count inversely correlated with the frequencies of diploidy, aneuploidies for chromosomes 13 and 21 in OAT patients. Twenty-two cycles of ICSI and 18 embryo transfers were performed in 20 couples. Only three cases achieved successful pregnancies. CONCLUSIONS: A higher incidence of meiotic errors and lower sperm counts was found in sperm from OAT patients.

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Section: Discussionsupporting

confidence: 93%

The high incidence of meiotic errors increases with decreased sperm count in severe male factor infertilities

Pang¹,

Kim²,

Lee³

et al. 2005

Human Reproduction

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“…Increased gonosomal aneuploidies were also reported in the sperm of oligoasthenoteratozoospermic patients [23]. Van Opstal and colleagues [33] prenatally evaluated 9 ICSI pregnancies and found out that 7 were paternally transmitted chromosome aberrations and 6 cases were sex chromosome abnormalities.…”

Section: Discussionmentioning

confidence: 96%

Sperm Chromosomal Abnormalities In Patients With Unexplained Recurrent Abortions

Al-Hassan

Hellani

Al-Shahrani

et al. 2005

Archives of Andrology

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“…Oligozoospermic men are frequent candidates for ICSI, which is known to be a more invasive procedure than routine IVF (Devroey and Van Steirteghem, 2004). Some studies have reported a higher risk for de novo chromosomal anomalies of paternal origin (Van Opstal et al, 1997) in fetuses (Van Steirteghem et al, 2002) and children (Aboulghar et al, 2001) issued from the ICSI procedure. These aberrations are likely related to the high aneuploidy rates observed in the sperm of infertile men.…”

Section: Discussionmentioning

confidence: 99%

High Frequency of Sex Chromosomal Disomy in Spermatozoa of Lebanese Infertile Men

Younes

Hazzouri

Chaaban

et al. 2010

Journal of Andrology

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In Lebanon, assisted reproductive techniques (ART) are widely used to overcome infertility, but the genetic risk associated with these techniques is still ignored. In this study, in order to estimate the transmission risk of paternal chromosomal anomalies to ART offspring, the meiotic segregation of chromosomes X, Y, 18, and 21 was analyzed by fluorescent in situ hybridization on the spermatozoa of 19 Lebanese infertile men. Our results show significantly higher frequencies of sex chromosome disomies in the group of patients with oligozoospermia compared with a control group of fertile males. Interestingly, the sex chromosome aneuploidy rates were highly variable between oligozoospermic patients, and ranged between 0.9% and 12.87%. No significant increase in aneuploidy rates was found for the group of nonoligozoospermic patients with asthenozoospermia and/or teratozoospermia. In addition, the disomy rate for chromosome 21 was analyzed in 8 patients, in whom higher disomy rates were shown as compared with the controls. Altogether, the results suggest that Lebanese oligozoospermic men undergoing ART may have an increased risk of transmitting sex chromosome anomalies to their offspring, as well as, in some cases, trisomy 21. Based on this work, genetic counseling programs for Lebanese infertile couples undergoing ART procedures should be developed, in order to improve the investigation and selection of Lebanese infertile couple candidates for ART procedures and optimize the choice of ART techniques.

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Determination of the parent of origin in nine cases of prenatally detected chromosome aberrations found after intracytoplasmic sperm injection

Cited by 121 publications

References 12 publications

The high incidence of meiotic errors increases with decreased sperm count in severe male factor infertilities

The high incidence of meiotic errors increases with decreased sperm count in severe male factor infertilities

Sperm Chromosomal Abnormalities In Patients With Unexplained Recurrent Abortions

High Frequency of Sex Chromosomal Disomy in Spermatozoa of Lebanese Infertile Men

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