Determination of the pharmaceuticals–nano/microplastics in aquatic systems by analytical and instrumental methods

Pashaei, Reza; Dzingelevičienė, Reda; Abbasi, Sajjad; Szultka‐Młyńska, Małgorzata; Buszewski, Bogusław

doi:10.1007/s10661-022-09751-w

Cited by 21 publications

(6 citation statements)

References 187 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanoplastics are an emerging environmental pollution, and widely occur in global aquatic ecosystems [ 76 , 77 ]. The transgenerational effects of microplastics and nanoplastics are receiving increasing attention due to risks to the health of the offspring [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Sulfonate-Modified Polystyrene Nanoparticle at Precited Environmental Concentrations Induces Transgenerational Toxicity Associated with Increase in Germline Notch Signal of Caenorhabditis elegans

Wang

2023

Toxics

View full text Add to dashboard Cite

Recently, the transgenerational toxicity of nanoplastics has received increasing attention. Caenorhabditis elegans is a useful model to assess the transgenerational toxicity of different pollutants. In nematodes, the possibility of early-life exposure to sulfonate-modified polystyrene nanoparticle (PS-S NP) causing transgenerational toxicity and its underlying mechanisms were investigated. After exposure at the L1-larval stage, transgenerational inhibition in both locomotion behavior (body bend and head thrash) and reproductive capacity (number of offspring and fertilized egg number in uterus) was induced by 1–100 μg/L PS-S NP. Meanwhile, after exposure to 1–100 μg/L PS-S NP, the expression of germline lag-2 encoding Notch ligand was increased not only at the parental generation (P0-G) but also in the offspring, and the transgenerational toxicity was inhibited by the germline RNA interference (RNAi) of lag-2. During the transgenerational toxicity formation, the parental LAG-2 activated the corresponding Notch receptor GLP-1 in the offspring, and transgenerational toxicity was also suppressed by glp-1 RNAi. GLP-1 functioned in the germline and the neurons to mediate the PS-S NP toxicity. In PS-S NP-exposed nematodes, germline GLP-1 activated the insulin peptides of INS-39, INS-3, and DAF-28, and neuronal GLP-1 inhibited the DAF-7, DBL-1, and GLB-10. Therefore, the exposure risk in inducing transgenerational toxicity through PS-S NP was suggested, and this transgenerational toxicity was mediated by the activation of germline Notch signal in organisms.

show abstract

Section: Discussionmentioning

confidence: 99%

Sulfonate-Modified Polystyrene Nanoparticle at Precited Environmental Concentrations Induces Transgenerational Toxicity Associated with Increase in Germline Notch Signal of Caenorhabditis elegans

Wang

2023

Toxics

View full text Add to dashboard Cite

show abstract

“…Significant concerns have been raised about the various effects of micro and nanoplastics on human health [ 12 , 26 , 27 , 28 ], although there is no universal agreement on them, also because the reliability of in vitro models is somewhat questioned [ 29 ]. Nanoplastics, in particular, have been shown to have the ability to bioaccumulate and invade the food chain [ 12 , 30 , 31 ]. While there are very limited human data, there is evidence from animal studies, but most of them focus only on specific types of micro- and nanoplastics, while some common types remain substantially uninvestigated; furthermore, there is still a lack of standardized methods for correct definition and detection of microplastics (MP) and nanoplastics (NP) [ 27 , 32 ].…”

Section: Sources and Concernsmentioning

confidence: 99%

Current Concerns about Microplastics and Nanoplastics: A Brief Overview

Morreale,

La Mantia

2024

Polymers

View full text Add to dashboard Cite

The widespread and increasing use of plastic-based goods in the present-day world has been raising many concerns about the formation of microplastics, their release, their impacts on the environment and, ultimately, on living organisms. These concerns are even greater regarding nanoplastics, i.e., nanosized microplastics, which may have even greater impacts. In this brief review, although without any claim or intention to exhaustively cover all the aspects of such a complex and many-sided issue, the very topical problem of the formation of microplastics, and the even more worrisome nanoplastics, from polymer-based products was considered. The approach is focused on a terse, straightforward, and easily accessible analysis oriented to the main technological engineering aspects regarding the sources of microplastics and nanoplastics released into the environment, their nature, some of the consequences arising from the release, the different polymers involved, their technological form (i.e., products or processes, with particular attention towards unintentional release), the formation mechanisms, and some possible mitigation pathways.

show abstract

“…Such reactions also occur in aqueous mediums, including sewage water, even at trace levels (ng L −1 to μg L −1 ). While traditional identification methods, such as liquid chromatography coupled to tandem mass spectrometry (HPLC‐MS/MS) can detect dexamethasone, the identification of intermediates remains challenging due to limited knowledge on the environmental transformation mechanisms, as well as the need for high‐resolution techniques [20] . On this basis, theory‐experiment studies may contribute to identify possible degradation byproducts of the pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

“…While traditional identification methods, such as liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) can detect dexamethasone, the identification of intermediates remains challenging due to limited knowledge on the environmental transformation mechanisms, as well as the need for high-resolution techniques. [20] On this basis, theory-experiment studies may contribute to identify possible degradation byproducts of the pharmaceuticals. Quantumbased calculations are herein used as a first step to assist in monitoring pollutants and their degradation products.…”

Section: Introductionmentioning

confidence: 99%

Identifying the Degradation Products of Dexamethasone for COVID‐19 Treatment in Mexico City's Wastewater: Theory and Experiments

Udaeta,

Rodríguez‐Varela,

Cruz‐Narváez

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

Quantum chemistry calculations were performed to elucidate the reaction sites and degradation routes of dexamethasone. Flow Injection Analysis Electrospray Fourier‐Transform Ion Cyclotron Resonance Mass Spectrometry (FIA‐ESI‐FTCIR‐MS) was used to identify dexamethasone and its byproducts in Mexico City's wastewater, guided by results from ab‐initio calculations on the bond energy analysis and thus propose possible degradation routes. Products of hydroxylation/reduction, decarbonylation/formylation and defluorination reactions were identified. The results of this study contribute to the identification of the degradation products of drugs commonly used in the treatment of COVID‐19 in urban areas. Through wastewater analysis and computationally assisted Mass‐Spectrometry techniques, an alternative approach is presented to identify byproducts in complex matrices when analytical standards are unavailable or in case of limited understanding on the stability of the degradation byproducts in aqueous medium.

show abstract

Determination of the pharmaceuticals–nano/microplastics in aquatic systems by analytical and instrumental methods

Cited by 21 publications

References 187 publications

Sulfonate-Modified Polystyrene Nanoparticle at Precited Environmental Concentrations Induces Transgenerational Toxicity Associated with Increase in Germline Notch Signal of Caenorhabditis elegans

Sulfonate-Modified Polystyrene Nanoparticle at Precited Environmental Concentrations Induces Transgenerational Toxicity Associated with Increase in Germline Notch Signal of Caenorhabditis elegans

Current Concerns about Microplastics and Nanoplastics: A Brief Overview

Identifying the Degradation Products of Dexamethasone for COVID‐19 Treatment in Mexico City's Wastewater: Theory and Experiments

Contact Info

Product

Resources

About