Determination of the stereoisomeric impurities of sitafloxacin by capillary electrophoresis with dual chiral additives

Meng, Ranran; Kang, Jingwu

doi:10.1016/j.chroma.2017.05.010

Cited by 23 publications

(16 citation statements)

References 26 publications

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“…Three classes of low molecular weight compounds were reported as CS. These are CS with a central ion (i.e., ligand exchangers [78,79], an ion-pair selector [80]), ILs [31,81,82] and a tetracycline antibiotic [83]. An IL implemented in a ligand exchanger is discussed under ILs.…”

Section: Low Molecular Weight Compoundsmentioning

confidence: 99%

“…The copper(II)- d -phenylalanine (Cu(II)- d -Phe) complex was used with γ-CD as dual CSs for the determination of sitafloxacin and its enantiomeric impurities [79]. Figure 6a–c show the electrochromatograms of sitafloxacin and its impurities using γ-CD, Cu(II)- d -Phe and γ-CD-Cu(II)- d -Phe, respectively.…”

Section: Low Molecular Weight Compoundsmentioning

confidence: 99%

“…There have been reports on the improved chiral recognition in CLE-EKC by the addition of SDS micelles into the BGS [85]. Indeed, the use of SDS micelles was also critical in the separation of sitafloxacin and its impurities [79]. This was further validated in a report that used copper(II)- l -isoleucine complex with SDS micelles for the simultaneous analysis of ofloxacin enantiomers and six related impurities [78].…”

Section: Low Molecular Weight Compoundsmentioning

confidence: 99%

“…Peaks: 1 = impurity C ( R , S , R ), 2 = impurity B ( S , S , R ), 3 = impurity A ( R , R , S ), 4 = sitafloxacin ( S , R , S ). Reprinted with permission from [79].…”

Section: Figurementioning

confidence: 99%

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Chiral Selectors in Capillary Electrophoresis: Trends during 2017–2018

Quirino

2019

Molecules

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Chiral separation is an important process in the chemical and pharmaceutical industries. From the analytical chemistry perspective, chiral separation is required for assessing the fit-for-purpose and the safety of chemical products. Capillary electrophoresis, in the electrokinetic chromatography mode is an established analytical technique for chiral separations. A water-soluble chiral selector is typically used. This review therefore examines the use of various chiral selectors in electrokinetic chromatography during 2017–2018. The chiral selectors were both low and high (macromolecules) molecular mass molecules as well as molecular aggregates (supramolecules). There were 58 papers found by search in Scopus, indicating continuous and active activity in this research area. The macromolecules were sugar-, amino acid-, and nucleic acid-based polymers. The supramolecules were bile salt micelles. The low molecular mass selectors were mainly ionic liquids and complexes with a central ion. A majority of the papers were on the use or preparation of sugar-based macromolecules, e.g., native or derivatised cyclodextrins. Studies to explain chiral recognition of macromolecular and supramolecular chiral selectors were mainly done by molecular modelling and nuclear magnetic resonance spectroscopy. Demonstrations were predominantly on drug analysis for the separation of racemates.

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Section: Low Molecular Weight Compoundsmentioning

confidence: 99%

Section: Low Molecular Weight Compoundsmentioning

confidence: 99%

Section: Low Molecular Weight Compoundsmentioning

confidence: 99%

“…Peaks: 1 = impurity C ( R , S , R ), 2 = impurity B ( S , S , R ), 3 = impurity A ( R , R , S ), 4 = sitafloxacin ( S , R , S ). Reprinted with permission from [79].…”

Section: Figurementioning

confidence: 99%

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Chiral Selectors in Capillary Electrophoresis: Trends during 2017–2018

Quirino

2019

Molecules

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“…CE has proved to be one of the most effective methods for enantiomers' separation due to its high efficiency, robustness, low cost, simplicity, and diversity regarding different modes, such as ACE , MEKC , and NACE . The enantioseparation can be achieved using different types of chiral selectors, such as cyclodextrin and its derivatives , cyclofructans , crown ether , DNA , macrocyclic antibiotics , ionic liquids , chiral metal‐ion complexes , and proteins . However, when using selectors with UV absorbances, such as proteins and DNA, or when the separation is combined with mass spectrometric detection, the bad effects of selectors on detection must be considered.…”

Section: Introductionmentioning

confidence: 99%

Predefine resolution of enantiomers in partial filling capillary electrophoresis and two discontinuous function plugs coupling in‐capillary

et al. 2018

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In common partial filling CE (PF-CE), the capillary contains the selectors plug between the injection and detector end to avoid the selector going into the detector zone. To expand this method, we propose a mode of two discontinuous function plugs coupling in-capillary, named as plug-plug PF-CE (ppPF-CE). Initially, we present the method to predefine the effective length of chiral selector to meet the requirement of enantiomers' resolution, which could avoid some experimental procedures. With α-CD as a chiral selector, a satisfactory resolution of enantiomers d,l-tryptophan and d,l-tyrosine was obtained with a partial filling α-CD plug of optimal length and concentration. Subsequently, a second plug containing hydroxypropyl methylcellulose, organic solvents (acetonitrile and methanol), anionic and cationic surfactants (SDS and CTAB), and different concentrations of sodium phosphate buffer was inserted after the selector plug. Effects of plug-plug filling on enantiomers' migration and resolution are discussed. The ppPF-CE might be a new flexible mode for CE application.

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Capillary electrophoretic methods for quality control analyses of pharmaceuticals: A review

Řemínek

Foret

2020

Electrophoresis

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Capillary electrophoresis represents a promising technique in the field of pharmaceutical analysis. The presented review provides a summary of capillary electrophoretic methods suitable for routine quality control analyses of small molecule drugs published since 2015. In total, more than 80 discussed methods are sorted into three main sections according to the applied electroseparation modes (capillary zone electrophoresis, electrokinetic chromatography, and micellar, microemulsion, and liposome-electrokinetic chromatography) and further subsections according to the applied detection techniques (UV, capacitively coupled contactless conductivity detection, and mass spectrometry). Key parameters of the procedures are summarized in four concise tables. The presented applications cover analyses of active pharmaceutical ingredients and their related substances such as degradation products or enantiomeric impurities. The contribution of reported results to the current knowledge of separation science and general aspects of the practical applications of capillary electrophoretic methods are also discussed.

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Determination of the stereoisomeric impurities of sitafloxacin by capillary electrophoresis with dual chiral additives

Cited by 23 publications

References 26 publications

Chiral Selectors in Capillary Electrophoresis: Trends during 2017–2018

Chiral Selectors in Capillary Electrophoresis: Trends during 2017–2018

Predefine resolution of enantiomers in partial filling capillary electrophoresis and two discontinuous function plugs coupling in‐capillary

Capillary electrophoretic methods for quality control analyses of pharmaceuticals: A review

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