Determination of the transcriptional level of long non-coding RNA NEAT-1, downstream target microRNAs, and genes targeted by microRNAs in diabetic neuropathy patients

Asadi, Gelayol; Varmaziar, Fatemeh Rezaei; Karimi, Mojgan; Rajabinejad, Misagh; Ranjbar, Sedigheh; Karaji, Ali Gorgin; Salari, Farhad; Hezarkhani, Leila Afshar; Rezaiemanesh, Alireza

doi:10.1016/j.imlet.2021.01.007

Cited by 24 publications

(19 citation statements)

References 42 publications

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“…Both lncRNA HCG18 and nuclear enriched abundant transcript 1 (NEAT1) have been reported to contribute to the pathogenesis of diabetic neuropathy. 55,56…”

Section: Role In Diabetic Neuropathymentioning

confidence: 99%

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Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers

Yan

Chen

Yang

et al. 2021

DMSO

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Diabetes mellitus is one of the most widespread metabolic diseases in the world, and diabetic foot ulcer (DFU), as one of its chronic complications, not only causes a large amount of physiological and psychological pain to patients but also places a tremendous burden on the entire economy and society. Despite significant advances in knowledge on the mechanism and in the treatment of DFU, clinical practice is still not satisfactory, and our understanding of its cellular and molecular pathogenesis is far from complete. Fortunately, progress in studying the roles of long non-coding RNAs (lncRNAs), which play important regulatory roles in the expression of genes at multiple levels, suggests that we can apply them in the early diagnosis and potential targeted intervention of DFU. In this review, we briefly summarize the current knowledge regarding the functional roles and potential mechanisms of reported lncRNAs in regulating DFU.

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“…Both lncRNA HCG18 and nuclear enriched abundant transcript 1 (NEAT1) have been reported to contribute to the pathogenesis of diabetic neuropathy. 55,56…”

Section: Role In Diabetic Neuropathymentioning

confidence: 99%

“…Asadi et al found an increased expression of NEAT1, ITGA4, SESN1, and SESN3, as well as a decreased expression of miR-183-5p and miR-433-3p, in patients with diabetic neuropathy. 56 Their receiver operating characteristics (ROC) curve analyses indicated that these dysregulated molecules could be potential biomarkers in diabetic neuropathy.…”

Section: Dovepressmentioning

confidence: 99%

Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers

Yan

Chen

Yang

et al. 2021

DMSO

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“…Autophagy is promoted by nucleus p53, whereas it is inhibited by cytosolic p53. P53 translocate to the nucleus in response to stress and stimulates Sestrin1/2 expression, which can trigger autophagy via the mTOR/AMPK network (Asadi et al, 2021; Budanov & Karin, 2008). The widespread lack of heterozygosity of the p53 gene on chromosome 17p13 implies that this molecule is important in NSCLC etiology.…”

Section: The Role Of Autophagy In Lung Cancermentioning

confidence: 99%

The roles, controversies, and combination therapies of autophagy in lung cancer

Wang

Zhou

Yang

2021

Cell Biology International

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Lung cancer is one of the leading causes of death among men and women worldwide. The disease initially has a silent phenotype, which leads to the progression of the disease and ultimately the lack of proper response to routine treatments. Autophagy, known as an intracellular “recycle bin” for the degradation of defective proteins and molecules, is one of the mechanisms that has been considered in the context of cancer in recent years. This study aims to provide a comprehensive review of published articles on autophagy in the context of lung cancer to have a complete view of the role of autophagy in lung cancer and its possible treatments. PubMed, Scopus, and Google Scholar were searched until June 15 to find related articles. No specific search filters or restrictions were applied. The results were entered into reference management software for aggregation and management. The full text of all articles was screened and studied. In conclusion, studies on the exact function of autophagy in lung cancer are contradictory, but what can be concluded from a review of literature on lung cancer is that targeting autophagy combined with traditional routine therapies such as chemotherapy, especially in advanced stages of lung cancer, can be an effective anticancer approach.

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“…Lung cancer is one of the leading causes of tumor death worldwide. 19.3 million new cancer cases are reported in 2020, including 1.79 million deaths, which account for 20% of all cancer death worldwide, due to lung cancer [1,2]. Over 200,000 new lung cancer cases are expected to be detected in the United States (US) in 2021.…”

Section: Introductionmentioning

confidence: 99%

“…1). These signaling pathways may, thus, play a role in a wide range of disorders, including cancer [16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Autophagy-related signaling pathways in non-small cell lung cancer

et al. 2021

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Lung cancer is one of the most prevalent causes of morbidity and mortality in both men and women across the globe. The disease has a quiet phenotype at first, which leads to chronic tumor development. Non-small cell lung cancer (NSCLC) is the most common kind of lung cancer, accounting for 85 percent of all lung malignancies. Autophagy has been described as an intracellular "recycle bin" where damaged proteins and molecules are degraded. Autophagy regulation is mainly dependent on signaling pathways such as phosphoinositide 3-kinases (PI3K), AKT, and the mammalian target of rapamycin (mTOR). In the context of NSCLC, studies on these signaling pathways are inconsistent, but our literature review suggests that the inhibition of mTOR, PI3K/AKT, and epidermal growth factor receptor signaling pathways by different medications can active autophagy and inhibit NSCLC progression. In conclusion, signaling pathways related to autophagy are effective therapeutic approaches for the treatment of NSCLC.

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Determination of the transcriptional level of long non-coding RNA NEAT-1, downstream target microRNAs, and genes targeted by microRNAs in diabetic neuropathy patients

Cited by 24 publications

References 42 publications

Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers

Emerging Roles of Long Non-Coding RNAs in Diabetic Foot Ulcers

The roles, controversies, and combination therapies of autophagy in lung cancer

Autophagy-related signaling pathways in non-small cell lung cancer

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