The radio-activity produced during the irradiation of 63,65 Cu, 59 Co, 93 Nb and 121,123 Sb targets with α-particles have been measured using activation technique. The yields of radioactive isotopic products 66,67,68 Ga, 61 Cu, 96g,m Tc and 123,124,126 I have been determined in the energy range ≈ 10-40 MeV using stacked foil technique. Radioactive counting of samples was performed with a high-resolution gamma-spectrometer. As light ion beams produce an extremely narrow layer of activities in the surface of a material, these reactions may be useful for thin layer activation study.