Determination of thermal conductivities of biological tissue protein

Due to their attributes, the application of medical lasers is on the rise in numerous medical fields. From a biomedical point of view, the most interesting applications are the thermal interactions and the photoablative interactions, which effectively remove tissue without excessive heat damage to the remaining tissue. The objective of this work is to create a theoretical model for heat transfer in the tissue following its interaction with the laser beam to predict heat transfer during medical laser surgery procedures. The dimensions of the ablated crater (shape and ablation depth) were determined by computed tomography imaging. COMSOL Multiphysics software was used for temperature modelling. The parameters of tissue and blood, such as density, specific heat capacity, thermal conductivity and diffusivity, were calculated from the chemical ratio. The parameters of laser-tissue interaction, such as absorption and reflection coefficients, were experimentally determined. The parameters of the laser beam were power density, repetition frequency, pulse length and spot dimensions. Heat spreading after laser interaction with tissue was captured using a Fluke thermal camera. The model was verified for adipose tissue, skeletal muscle tissue and heart muscle tissue.

show abstract

“…Values used for theoretical modelling are in table 1. These values are very similar to those reported in the literature [8][9][10].…”

Section: Resultssupporting

confidence: 91%

Heat transfer modelling of pulsed laser-tissue interaction

Urzová

Jelínek

2018

Laser Phys.

View full text Add to dashboard Cite

show abstract

“…The simulation gives a solution for the governing equation to provide a As its value goes tighter, the solution accuracy increases at the expense of the computational time for a given mesh. In our case, this value is good enough because the inputs (material properties) in our model are approximate values [259][260][261][262][263][264][265][266][267][268][269]. The biological tissues properties vary between individuals, due to different age and health status for example.…”

Section: Bioheat Transfer Modelmentioning

confidence: 99%

“…Ascertaining the extent of thermal damage and its degree in tissue is required from the heat transfer models of hyperthermia [259][260][261][262][263][264][265][266][267][268][269][270][271][272][273][274][275]. Accurate estimation of these thermal properties is imperative to determine the heat transfer and its effect on a biological system.…”

Section: Input Parametersmentioning

confidence: 99%

Tilted Fiber Bragg Grating Active Heater for Controlled and Localised Hyperthermia

Alqarni¹

View full text Add to dashboard Cite

We present data from localized heat inducement studies at both cellular and tissue levels along with a computational model built to predict the temperature increase and damage extent in tissues receiving hyperthermia treatment by a fiber-based active heater. This novel fiber-based active heater serves as a heat source and a temperature sensor. Five important insights are highlighted from this thesis work.First, heat-induced controlled cell deaths were observed experimentally in the three cell lines with MCF-10A being more susceptible to heat compared to HEK 293 and MCF7 cells. Second, comparison between the phantom tissue and ex vivo experimental and computational results shows a lesion size of 5×12 mm and 4.87×11.6 mm in the phantom tissue and 7×15 mm and 8.8×14.3 mm in the ex vivo studies at pumping power of 1.8 W for 10 minutes respectively. Thus, this computational model is able to provide information about the heat transfer characteristics caused by the active heater in living biological tissue.

show abstract

Non-equilibrium thermodynamic properties and internal dynamics of 32-residue beta amyloid fibrils

Shekaari

Jafari

2020

Physica A: Statistical Mechanics and its Applications

View full text Add to dashboard Cite

Determination of thermal conductivities of biological tissue protein

Cited by 3 publications

References 17 publications

Heat transfer modelling of pulsed laser-tissue interaction

Heat transfer modelling of pulsed laser-tissue interaction

Tilted Fiber Bragg Grating Active Heater for Controlled and Localised Hyperthermia

Non-equilibrium thermodynamic properties and internal dynamics of 32-residue beta amyloid fibrils

Contact Info

Product

Resources

About