Determination of Three Water-Soluble Active Ingredients in Qiangli Yingqiao Containing Vc Tablets by Capillary Zone Electrophoresis

Zhang, Z.; Chen, X.; Hu, Zhide

doi:10.1080/10826079708000487

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…In particular, an HPLC-based analytical method for the determination (PM and E) [1] has been developed and successfully applied to nasal drops and tablets [2]. CZE-based methods [3][4][5] and MECK (Micellar Electrophoretic Capillary Chromatography) have been developed for determination of pseudoephedrine, acetaminophen, chlorpheniramine, ascorbic acid and dextromethorphan [6][7][8]. An accurate and rapid method based on CZE in TBS (pH = 8.5) for the determination of codeine, DPH, E and noscapine in a syrup formulation was described [9].…”

Section: Introductionmentioning

confidence: 99%

Quick Single Run Capillary Zone Electrophoresis Determination of Active Ingredients and Preservatives in Pharmaceutical Products

Franco¹,

Jasionowska²

2013

AJAC

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The paper deals with the development of a rapid and efficient Capillary Zone Electrophoresis (CZE) method for Quality Control analysis of pharmaceutical preparations containing antihistamines, decongestants, anticholinergic remedies and preservatives. Active ingredients of interest are: ChlorPheniramine Maleate (CPM), DiPhenhydramine Hydrochloride (DPH), Ephedrine hydrochloride (E), Isopropamide Iodide (II), Pheniramine Maleate (PM), Lidocaine hydrochloride (L), Tetracaine hydrochloride (T), Clopamide Hydrochloride (CH), DiHydroErgochristine (DHE), PhenylEphrine hydrochloride (PE) and Acetaminophen (A). Preservatives studied are: MethylParaben (MeP), EthylParaben (EtP), Pro-pylParaben (PrP), ButylParaben (BuP), p-HydroxyBenzoic Acid (p-HBA). All these analytes were separated in a single run using 60 mM tetraborate buffer solution (TBS) pH = 9.2 as a BackGround Electrolyte (BGE) by using an uncoated fused silica capillary of I.D. = 50 μm and applying a voltage of 25 kV in the first part of the electropheretic run (up to 5.8 min) and 30 kV for the remaining time. The hydrodynamic pressurization of the inlet vial was 20 psi at 7.2 min. up to the end of analysis. Total separation time was of 7.5 min. The method was then successfully validated and applied to the simultaneous determination of active ingredients and preservatives. Good repeatability, linearity, and sensitivity were demonstrated. Precision of migration time (t m) was RSD% < 0.53% and of corrected peak area (A c) was RSD% < 6.15%. The linearity evaluation gave 0.9928 < r 2 < 1.000. LOD and LOQ, accuracy (recovery) and ruggedness were evaluated for each analyte demonstrating the good reliability of the method. Analyses of some pharmaceutical real samples were performed.

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Section: Introductionmentioning

confidence: 99%

Quick Single Run Capillary Zone Electrophoresis Determination of Active Ingredients and Preservatives in Pharmaceutical Products

Franco¹,

Jasionowska²

2013

AJAC

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The application of capillary electrophoresis to the analysis of vitamins in food and beverages

Trenerry¹

2001

Electrophoresis

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Capillary electrophoretic (CE) methods have been used to separate and determine a wide range of water-soluble vitamins in pharmaceutical preparations, but has found limited application in determining vitamins at naturally occurring levels in food and beverages. CE has been used to determine vitamin C in fruits and beverages, niacin in a range of foods and thiamine in samples of meat and milk. The CE methodologies used to determine vitamins in pharmaceutical preparations and biological fluids are also included as examples of the effectiveness of CE in vitamin analysis.

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Development and validation of an MEKC method for determination of nitrogen‐containing drugs in pharmaceutical preparations

et al. 2008

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A fast and accurate micellar electrokinetic capillary chromatography method was developed for quality control of pharmaceutical preparations containing cold remedies as acetaminophen, salicylamide, caffeine, phenylephrine, pseudoephedrine, norephedrine and chlorpheniramine. The method optimization was realized on a Beckman P/ACE System MDQ instrument. The baseline separation of seven analytes was performed in an uncoated fused silica capillary internal diameter (ID)=50 microm using tris-borate (20 mM, pH=8.5) containing sodium dodecyl sulphate 30 mM BGE. On line-UV detection at 214 nm was performed and the applied voltage was 10 kV. The operating temperature was 25 degrees C. After experimental conditions optimization, the proposed method was validated. The evaluated parameters were: precision of migration time and of corrected peak area ratio, linearity range, limit of detection, limit of quantification, accuracy (recovery), ruggedness and applicability. The method was then successfully applied for the analysis of three pharmaceutical preparations containing some of the analytes listed before.

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Determination of Three Water-Soluble Active Ingredients in Qiangli Yingqiao Containing Vc Tablets by Capillary Zone Electrophoresis

Cited by 5 publications

References 12 publications

Quick Single Run Capillary Zone Electrophoresis Determination of Active Ingredients and Preservatives in Pharmaceutical Products

Quick Single Run Capillary Zone Electrophoresis Determination of Active Ingredients and Preservatives in Pharmaceutical Products

The application of capillary electrophoresis to the analysis of vitamins in food and beverages

Development and validation of an MEKC method for determination of nitrogen‐containing drugs in pharmaceutical preparations

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