Determination of topologic human brain representations and modifications of signs and symptoms of some neurologic disorders by the use of high level ultrasound

Meyers, Russell; Fry, F. J.; Fry, William J.; Eggleton, R. C.; Schultz, D. F.

doi:10.1212/wnl.10.3.271

Cited by 28 publications

(7 citation statements)

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“…Our experience in human neurosurgery in which high-level focused ultrasound was used to produce lesions through the intact skin, with a section of the temporal bone removed, bear out this conclusion [17]. It is our present position that if such methods were to be considered for human application, an acoustically transparent, rigid replacement for the temporal and parietal bone flap should be used.…”

Section: Resultsmentioning

confidence: 80%

Ultrasonic Visualization of Ultrasonically Produced Lesions in Brain

Fry¹

1970

Stereotact Funct Neurosurg

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Three anatomically discrete, ultrasonically produced brain lesions in the rhesus monkey have been visualized ultrasonically in the immediate post-lesion period, as well as three weeks later. After sacrifice at three weeks, the histologically prepared brain sections in the lesion area have been compared with the echogram information to verify lesion placement and size. The correlation data indicate that ultrasonic visualization means can be used to aid in the accurate placement of brain lesions. Additionally, the lesions can hopefully be controlled in size and shape by this means. Subsequent examination of the lesions over a long period of time also appears to be possible with ultrasonic visualization techniques. The implications of the methods for experimental animal and human brain modification are discussed. Considerably more work needs to be done to study ultrasonically produced brain lesions in fine detail utilizing the methods available in our Institute [4, 5] but we feel the present work is a good indication of the results which may ultimately be achieved.

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Section: Resultsmentioning

confidence: 80%

Ultrasonic Visualization of Ultrasonically Produced Lesions in Brain

Fry¹

1970

Stereotact Funct Neurosurg

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“…This may be a possible explanation, for most pathologists who have studied Parkinson patients claim that the initial lesions, and the most advanced, are in the substantia nigra. Against such an explanation is the claim by Meyers, Fry, Fry, Eggleton, and Schultz (1960) that nigral lesions are very effective in controlling tremor.…”

Section: Methodsmentioning

confidence: 99%

Involuntary movements following stereotactic operations for Parkinsonism with special reference to hemi-chorea (ballismus)

Hughes¹

1965

Journal of Neurology, Neurosurgery & Psychiatry

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“…T he u ltraso n ic in s tru m e n ta tio n c u rre n tly in use by th e au th o rs and co llab o rato rs on th e h u m an has been em ployed to m odify singly and in various co m b in atio n s p o rtio n s of a v a rie ty of b rain stru c tu re s to affect in a stepw ise fashion [3,4,5,8] T he u ltraso n ic m eth o d as now em ployed by us on the hu m an provides a flexibility, sa fe ty an d g en erality of ap p ro ach n o t possible b y an y m ethod re q u irin g th e in se rtio n o f probes, can n u lae, etc. into regions of b rain to be affected.…”

Section: * 2 ] -mentioning

confidence: 99%