Determination of Total Phenolic and Flavonoid Contents of Leonurus cardiaca L. in Compare with Antioxidant Activity

Jafari, Saeid; Moradi, Abolfath; Salaritabar, A.; Hadjiakhoondi, Abbas; Khanavi, Mahnaz

doi:10.3923/rjbsci.2010.484.487

Cited by 15 publications

(17 citation statements)

References 6 publications

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“…Pharmacological studies have established that L. cardiaca possesses additional antimicrobial [ 286 , 292 ], antioxidant [ 289 , 293 ], anti-inflammatory [ 294 , 295 ], antinociceptive [ 296 ], neuroprotective [ 297 ], sedative [ 298 ], and even anticancer effects [ 299 ]. The findings obtained by Rezaee-Asl and coworkers, using the formalin , tail flick , and hot-plate tests, assess that central and peripheral mechanisms are involved in the antinociceptive activity of the motherwort extract.…”

Section: Species Of the Lamiaceae Family With Potential Analgesic/mentioning

confidence: 99%

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Uritu

Mihai

Stanciu

et al. 2018

Pain Research and Management

269

143

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Recently, numerous side effects of synthetic drugs have lead to using medicinal plants as a reliable source of new therapy. Pain is a global public health problem with a high impact on life quality and a huge economic implication, becoming one of the most important enemies in modern medicine. The medicinal use of plants as analgesic or antinociceptive drugs in traditional therapy is estimated to be about 80% of the world population. The Lamiaceae family, one of the most important herbal families, incorporates a wide variety of plants with biological and medical applications. In this study, the analgesic activity, possible active compounds of Lamiaceae genus, and also the possible mechanism of actions of these plants are presented. The data highlighted in this review paper provide valuable scientific information for the specific implications of Lamiaceae plants in pain modulation that might be used for isolation of potentially active compounds from some of these medicinal plants in future and formulation of commercial therapeutic agents.

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Section: Species Of the Lamiaceae Family With Potential Analgesic/mentioning

confidence: 99%

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Uritu

Mihai

Stanciu

et al. 2018

Pain Research and Management

269

143

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“…At the scientific level, the bioactive properties of M. aquatica , L. dentata and L. cardiaca have been mostly associated with their phenolic constituents, which are generally major components in extracts obtained with polar solvents (e.g., water, ethanol, methanol, water/alcohol or water/acetone mixtures). The antioxidant capacity of polar extracts from these three plants has been previously tested through chemical antiradical assays [12,13,14,15,16,17,18,19,20]. Besides, neuroprotective effects of methanolic and aqueous extracts of M. aquatica aerial parts were shown to counteract oxidative stress in an H 2 O 2 -induced toxicity model in PC12 cells, along with the high ability to inhibit monoamine oxidase (MAO) and a moderate affinity towards GABA A receptor [6,21].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotection of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L.

et al. 2019

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The phenolic composition of hydroethanolic extracts of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L., obtained from plants grown under organic cultivation, was determined and their hepatoprotective effects were investigated in vitro. L. cardiaca extract was rich in phenylethenoid glycosides, especially lavandolifolioside (254 ± 36 μg/mg), whereas rosmarinic acid and eriodictyol-O-rutinoside were the major phenolic compounds of L. dentata and M. aquatica extracts, accounting for 68 ± 7 μg/mg and 145 ± 22 μg/mg, respectively. These differential phenolic components presumably account for their dissimilar antioxidant properties. While L. cardiaca extract showed moderate biological effects, M. aquatica extract displayed high antioxidant activity in chemical models, and that of L. dentata was effective in counteracting potassium dichromate-induced ROS generation in human hepatocarcinoma cells. Moreover, M. aquatica extract (50 μg/mL) and its mixture (50%/50%) with L. dentata extract displayed an effective cytoprotective effect.

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“…Extracts from motherwort demonstrated antioxidant activity in several in vitro studies. Polyphenolic compounds, mainly flavonoids (rutin) and derivatives of hydroxycinnamic acid (Matkowski and Piotrowska, , ; Masteiková et al ., ; Bernatoniene et al ., ; Jafari et al ., ) may be responsible for this effect.…”

Section: Introductionmentioning

confidence: 96%

Leonurus cardiaca L. (Motherwort): A Review of its Phytochemistry and Pharmacology

Wojtyniak

Szymański

Matławska

2012

Phytotherapy Research

102

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Leonurus cardiaca is a perennial plant indigenous to central Europe and Scandinavia, but it is also found in the area spanning temperate Russia to central Asia. It has been introduced to North America and has become established locally in the wild. Motherwort (Leonuri cardiacae herba) consists of aerial parts of Leonurus cardiaca gathered during the flowering period, dried at 35 °C and, according to European Pharmacopoeia 7th edition, should contain a minimum of 0.2% flavonoids, expressed as hyperoside. Compounds belonging to the group of monoterpenes, diterpenes, triterpenes, nitrogen- containing compounds, phenylpropanoids, flavonoids and phenolic acids, as well as volatile oils, sterols and tannins, have been identified in motherwort. Traditionally, extracts of the herb have been used internally, mainly for nervous heart conditions and digestive disorders. However, they have also been used for bronchial asthma, climacteric symptoms and amenorrhoea, as well as externally in wounds and skin inflammations. Mild negative chronotropic, hypotonic and sedative effects can be attributed to the herb and preparations thereof. Pharmacological studies have confirmed its antibacterial, antioxidant, anti-inflammatory and analgesic activity, as well as its effects on the heart and the circulatory system. Sedative and hypotensive activity has been demonstrated in clinical trials.

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Determination of Total Phenolic and Flavonoid Contents of Leonurus cardiaca L. in Compare with Antioxidant Activity

Cited by 15 publications

References 6 publications

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review

Hepatoprotection of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L.

Leonurus cardiaca L. (Motherwort): A Review of its Phytochemistry and Pharmacology

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