Determination of total phenolic content and antidiabetic, antioxidant and antiproliferative activities of Gypsophila pilulifera extracts grown by in vitro culture

Ustuner, Hatice; Nasircilar, Ayşe Gül; Servi, Hüseyin; Demir, Ümmühan; Sen, Ali; Gundogdu, Büşra; Gokturk, Ramazan Süleyman

doi:10.1016/j.bcab.2023.103014

Biocatalysis and Agricultural Biotechnology

2024

DOI: 10.1016/j.bcab.2023.103014

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Determination of total phenolic content and antidiabetic, antioxidant and antiproliferative activities of Gypsophila pilulifera extracts grown by in vitro culture

Hatice Ustuner,

Ayşe Gül Nasircilar,

Hüseyin Servi

et al.

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Cited by 3 publications

References 34 publications

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An updated overview of Gypsophila species: Phytochemical and pharmacological investigations

Kamali,

Talebi,

Mottaghipisheh

et al. 2024

Fitoterapia

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An updated overview of Gypsophila species: Phytochemical and pharmacological investigations

Kamali,

Talebi,

Mottaghipisheh

et al. 2024

Fitoterapia

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Utilizing HPLC-DAD, multivariate analysis, molecular docking, and in vitro validation methods to investigate phenolic compounds with potential antidiabetic properties in Fraxinus mandshurica

Guo,

Ho,

Bai

2024

Microchemical Journal

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Eco-friendly synthesis of silver nanoparticles using Phyllanthus niruri leaf extract: Assessment of antimicrobial activity, effectiveness on tropical neglected mosquito vector control, and biocompatibility using a fibroblast cell line model

Prabakaran,

Baranitharan,

Mathiyazhagan

et al. 2024

Open Chemistry

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Mosquitoes are rapidly advancing as vectors of several severe diseases. The increasing resistance of mosquitoes and the environmental harm caused by insecticides pose significant challenges for eradicating mosquito vectors. In this study, 18 plant extracts were tested for larvicidal properties against Aedes aegypti, Culex quinquefasciatus, and Anopheles stephensi larvae. Phyllanthus niruri (Pn) showed enhanced larvicidal activity in both laboratory and field trials. The biosynthesis of silver nanoparticles (AgNPs) using Pn leaf methanol extract (Pn-LME) was confirmed by UV-visible spectroscopy, X-ray diffraction, transmission electron microscopy, scanning electron microscopy, and Fourier-transform infrared spectroscopy. Among various concentrations, 3 mM AgNPs exhibited significant LC90 values of 0.83, 1.46, and 9.11 ppm compared to 9.25, 93.48, and 14.60 ppm of Pn-LME against A. stephensi, C. quinquefasciatus, and A. aegypti, respectively. This indicates the high mortality of mosquito vectors at low AgNP concentrations. Additionally, Pn-AgNPs showed enhanced antibacterial activity and no cytotoxicity in normal fibroblast cells (L929). Field trials demonstrated a 98.70% decrease in mosquito larval density at A. stephensi breeding sites, a 96.55% reduction at C. quinquefasciatus sites, and a 97.85% reduction at Ae. aegypti sites. This study presents an eco-friendly and cost-effective AgNP bio-pesticide synthesized from Pn leaves for controlling and preventing the transmission of filarial, dengue, and malaria vectors.

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Determination of total phenolic content and antidiabetic, antioxidant and antiproliferative activities of Gypsophila pilulifera extracts grown by in vitro culture

Cited by 3 publications

References 34 publications

An updated overview of Gypsophila species: Phytochemical and pharmacological investigations

An updated overview of Gypsophila species: Phytochemical and pharmacological investigations

Utilizing HPLC-DAD, multivariate analysis, molecular docking, and in vitro validation methods to investigate phenolic compounds with potential antidiabetic properties in Fraxinus mandshurica

Eco-friendly synthesis of silver nanoparticles using Phyllanthus niruri leaf extract: Assessment of antimicrobial activity, effectiveness on tropical neglected mosquito vector control, and biocompatibility using a fibroblast cell line model

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