Determination of trace elements in normal and diabetic whole blood by neutron activation analysis

El-Amri, F. A.; El-Saltani, H. A.; Dogadkin, N. N.; Ashour, I. A.

doi:10.1007/bf02917339

Cited by 4 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, there is no information about CrHis supplementation on trace element distribution in liver and kidney tissues of diabetic animals. However, these results are consistent with previous studies that diabetes decreases Cr, Zn, Mn, and Se and increases Cu and Fe in human and animals [5,26]. Kazi et al [30] reported that the mean values of Zn, Mn, and Cr were significantly reduced in blood and scalp hair samples of diabetic patients.…”

Section: Discussionsupporting

confidence: 93%

“…Some studies found that hyperglycemia was corrected by long-term Cr supplementation [10,17,18], while some could not find hypoglycemic effects [24,25]. Lower levels of Cr, Zn, and Se and higher Cu levels were found in patients with diabetes [5,22,26]. In the present study, a significant increase in levels of glucose and decrease in body weight and levels of Cr, Zn, Se, Mn was found in serum, liver, and kidney tissue of diabetic rats when compared to control rats.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

The Effects of Chromium Histidinate on Mineral Status of Serum and Tissue in Fat-Fed and Streptozotocin-Treated Type II Diabetic Rats

Doğukan

Şahin

Tuzcu

et al. 2009

Biol Trace Elem Res

View full text Add to dashboard Cite

The present study was conducted to investigate the effects of chromium histidinate (CrHis) against experimentally induced type II diabetes and on chromium (Cr), zinc (Zn), selenium (Se), manganese (Mn), iron (Fe), and copper (Cu) in serum, liver, and kidney of diabetic rats. The male Wistar rats (n = 60, 8 weeks old) were divided into four groups. Group I received a standard diet (12% of calories as fat); group II were fed standard diet and received CrHis (110 mcg CrHis/kg body weight per day); group III received a high-fat diet (HFD; 40% of calories as fat) for 2 weeks and then were injected with streptozotocin (STZ) on day 14 (STZ, 40 mg/kg i.p.; HFD/STZ); group IV were treated as group III (HFD/STZ) but supplemented with 110 mcg CrHis/kg body weight per day. The mineral concentrations in the serum and tissue were determined by atomic absorption spectrometry. Compared to the HFD/STZ group, CrHis significantly increased body weight and reduced blood glucose in diabetic rats (p < 0.001). Concentrations of Cr, Zn, Se, and Mn in serum, liver, and kidney of the diabetic rats were significantly lower than in the control rats (p < 0.0001). In contrast, higher Fe and Cu levels were found in serum and tissues from diabetic versus the non-diabetic rats (p < 0.001). Chromium histidinate supplementation increased serum, liver, and kidney concentrations of Cr and Zn both in diabetic and non-diabetic rats (p < 0.001). Chromium supplementation increased Mn and Se levels in diabetic rats (p < 0.001); however, it decreased Cu levels in STZ-treated group (p < 0.001). Chromium histidinate supplementation did not affect Fe levels in both groups (p > 0.05). The results of the present study conclude that supplementing Cr to the diet of diabetic rats influences serum and tissue Cr, Zn, Se, Mn, and Cu concentrations.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 94%

The Effects of Chromium Histidinate on Mineral Status of Serum and Tissue in Fat-Fed and Streptozotocin-Treated Type II Diabetic Rats

Doğukan

Şahin

Tuzcu

et al. 2009

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

Insights into the Age-Dependent Variation in Nutrition-Related Trace Elements in Diabetes Blood Using Total Reflection X-Ray Fluorescence

Manjunatha,

Bennal,

Hanumanthappa

et al. 2024

Biol Trace Elem Res

View full text Add to dashboard Cite

Selenium in global food systems

2001

View full text Add to dashboard Cite

Food systems need to produce enough of the essential trace element Se to provide regular adult intakes of at least 40 m g/d to support the maximal expression of the Se enzymes, and perhaps as much as 300 m g/d to reduce risks of cancer. Deprivation of Se is associated with impairments in antioxidant protection, redox regulation and energy production as consequences of suboptimal expression of one or more of the Secontaining enzymes. These impairments may not cause deficiency signs in the classical sense, but instead contribute to health problems caused by physiological and environmental oxidative stresses and infections. At the same time, supranutritional intakes of Se, i.e. intakes greater than those required for selenocysteine enzyme expression, appear to reduce cancer risk. The lower, nutritional, level is greater than the typical intakes of many people in several parts of the world, and few populations have intakes approaching the latter, supranutritional, level. Accordingly, low Se status is likely to contribute to morbidity and mortality due to infectious as well as chronic diseases, and increasing Se intakes in all parts of the world can be expected to reduce cancer rates.

show abstract

Determination of trace elements in normal and diabetic whole blood by neutron activation analysis

Cited by 4 publications

References 11 publications

The Effects of Chromium Histidinate on Mineral Status of Serum and Tissue in Fat-Fed and Streptozotocin-Treated Type II Diabetic Rats

The Effects of Chromium Histidinate on Mineral Status of Serum and Tissue in Fat-Fed and Streptozotocin-Treated Type II Diabetic Rats

Insights into the Age-Dependent Variation in Nutrition-Related Trace Elements in Diabetes Blood Using Total Reflection X-Ray Fluorescence

Selenium in global food systems

Contact Info

Product

Resources

About