Determination of trace levels of eleven bisphenol A analogues in human blood serum by high performance liquid chromatography–tandem mass spectrometry

Owczarek, Katarzyna; Kubica, Paweł; Kudłak, Błażej; Rutkowska, Aleksandra; Konieczna, A; Rachoń, Dominik; Namieśnik, Jacek; Wasik, Andrzej

doi:10.1016/j.scitotenv.2018.02.148

Cited by 96 publications

(46 citation statements)

References 30 publications

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“…Human plasma is a complex matrix rich in endogenous proteins and other biological compounds. ACN has previously been shown to be an extraction solvent that can produce significantly high recovery [25]. The use of ACN in the extraction method of this study gave good recovery and ruled out ion suppression.…”

Section: Discussionmentioning

confidence: 62%

Validation of a simple extraction procedure for bisphenol A identification from human plasma

et al. 2019

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The general population is exposed to bisphenol A (BPA) orally, parenterally, transdermally, and environmentally as a result of the use of BPA in food packaging, plastics, and personal care products. The majority of the population nowadays (91–99%) has detectable levels of BPA inside their body. In this study, we successfully performed an inexpensive, rapid, and simple protein precipitation procedure for extraction of BPA from human plasma, followed by analysis by LC-MS/MS. This method was specifically developed for handling large numbers of samples with minimum cost and volume of sample. The developed method was accurate, precise, and reproducible for quantification of BPA from human plasma samples in the concentration range of 10–2000 ng/mL. The method was performed on samples from 150 healthy volunteers who were enrolled in the study. The mean of observed BPA level was 2.22 ± 9.91 ng/mL. Higher BPA levels were observed for females compare to that of males (p-value = 0.002), the BPA levels were higher in participants 33 years of age and older compared to those less than 33 years of age (p-value = 0.000), then the BPA levels higher in subjects with tap water as source of drinking (p-value = 0.005). This method may be valuable for general risk assessment of BPA for a large and varied population because of its efficiency and economical aspects.

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Section: Discussionmentioning

confidence: 62%

Validation of a simple extraction procedure for bisphenol A identification from human plasma

et al. 2019

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“…Available data on exposure to BP analogues, however, are very limited, and only a few studies have focused on the detection of urinary levels of these bisphenols in infants and toddlers [ 8 , 28 , 38 ]. Indeed, only nine (i.e., BPA, BPAF, BPAP, BPB, BPF, BPM, BPP, BPS, and BPZ) of the most common BPs have previously been analyzed in urine obtained from adults and children [ 8 , 28 , 48 , 49 , 50 , 51 , 52 , 53 ]. The analysis of human urine is a preferred approach in monitoring total BP concentrations, as urinary excretion is the main route of BP elimination, independently of the exposure route [ 49 , 51 ].…”

Section: Introductionmentioning

confidence: 99%

Exposure to New Emerging Bisphenols Among Young Children in Switzerland

Lucarini

Krasniqi

Rosset³

et al. 2020

IJERPH

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Restrictions on the use of bisphenol A (BPA) in consumer products led to its replacement by various bisphenol (BP) analogues, yet young children’s exposure to these analogues has been poorly characterized so far. This study aimed to characterize infants’ and toddlers’ exposure to BPA and 14 emerging BP analogues (i.e., bisphenol AF, bisphenol AP, bisphenol B, bisphenol BP, bisphenol C (BPC), bisphenol E, bisphenol F (BPF), bisphenol G, bisphenol M (BPM), bisphenol P, bisphenol PH, bisphenol S (BPS), bisphenol TMC, and bisphenol Z). We extracted infants’ and toddlers’ urine from diapers (n = 109) collected in Swiss daycare centers as a practical and noninvasive alternative approach to urinary biomonitoring. Bisphenols were present in 47% of the samples, with BPC and BPM being the most frequently detected (23% and 25% of all samples, respectively). The mean concentrations of urinary BPS and BPF were greater than that of BPA. This contrasts with data reported previously. Furthermore, statistical analysis revealed a significant and negative correlation between urinary BPM concentration and the population’s age. Our results provide a first characterization of infants’ and toddlers’ exposure to bisphenols in Switzerland. This knowledge can be used to support ongoing biomonitoring studies and to prioritize exposure reduction and prevention strategies.

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“…Electrochemical sensors and liquid chromatography have increasingly been used in the last several years for the quantification of BPA in water and milk analysis [14,15]. High-performance liquid chromatography-tandem mass spectrometry methods can determine BPA, its major metabolite BPA-glucuronide, and eleven BPA analogues in human urine and blood serum [16,17]. Other analytical methods for the detection of BPA at trace levels in solid environmental matrices have recently been reviewed [18].…”

Section: Introductionmentioning

confidence: 99%

Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins

2020

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Quantitative analysis of endocrine-disrupting molecules such as bisphenol A (BPA) in freshwater to determine their widespread occurrence in environmental resources has been challenged by various adsorption and desorption processes. In this work, ion trap mass spectrometry (ITMS) analysis of BPA was aimed at studying its molecular interactions with titanium dioxide (TiO2) nanoparticles and milk whey proteins. Addition of sodium formate prevented TiO2 nanoparticles from sedimentation while enhancing the electrospray ionization (ESI) efficiency to produce an abundance of [BPA + Na]+ ions at m/z 251.0. More importantly, the ESI-ITMS instrument could operate properly during a direct infusion of nanoparticles up to 500 μg/mL without clogging the intake capillary. Milk protein adsorption of BPA could decrease the [BPA + Na]+ peak intensity significantly unless the proteins were partially removed by curdling to produce whey, which allowed BPA desorption during ESI for quantitative analysis by ITMS.

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Determination of trace levels of eleven bisphenol A analogues in human blood serum by high performance liquid chromatography–tandem mass spectrometry

Cited by 96 publications

References 30 publications

Validation of a simple extraction procedure for bisphenol A identification from human plasma

Validation of a simple extraction procedure for bisphenol A identification from human plasma

Exposure to New Emerging Bisphenols Among Young Children in Switzerland

Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins

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