Determination of traces of cyanide

Murty, G. E.; Viswanathan, T. S.

doi:10.1016/0003-2670(61)80162-1

Cited by 16 publications

(4 citation statements)

References 3 publications

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“…Therefore, these methods often require microdiffusion sample preparation. Modifications have been developed that yield more stable reagents and increased precision for this type of reaction (59,93,133,147,(163)(164)(165)(166).…”

Section: Spectrophotometric Luminescence and Atomic Absorption Methodsmentioning

confidence: 99%

The Analysis of Cyanide and its Breakdown Products in Biological Samples

Logue¹,

Hinkens²,

Baskin³

et al. 2010

Critical Reviews in Analytical Chemistry

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Cyanide is a toxic chemical that may be introduced into living organisms as a result of natural processes and/or anthropogenic uses (legal or illicit). Exposure to cyanide can be verified by analysis of cyanide or one of its breakdown products from biological samples. This verification may be important for medical, law-enforcement, military, forensic, research, or veterinary purposes. This review will discuss current bioanalytical techniques used for the verification of cyanide exposure, identify common problems associated with the analysis of cyanide and its biological breakdown products, and briefly address the metabolism and toxicokinetics of cyanide and its breakdown products in biological systems.

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Section: Spectrophotometric Luminescence and Atomic Absorption Methodsmentioning

confidence: 99%

The Analysis of Cyanide and its Breakdown Products in Biological Samples

Logue¹,

Hinkens²,

Baskin³

et al. 2010

Critical Reviews in Analytical Chemistry

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“…Br03~o-Arsanilic acid (278) cio,-Indirect, Ferroin as precipitant (169) ON" Barbituric acid (313) co2 Air Thymol blue, diethanolamine…”

Section: -mentioning

confidence: 99%

Light Absorption Spectrometry

Mellon¹,

Boltz²

1964

Anal. Chem.

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“…At present, the well-known Aldridge's method based on the formation of cyanogen bromide and its subsequent reaction with pyridine and benzidine to form a highly colored polymethine dye is still in use for the spectrophotometric determination of low concentrations of cyanide. 5 Its variants involve the use of reagents, such as pyrazalone 6 or barbituric acid, 7 instead of benzidine.…”

Section: Introductionmentioning

confidence: 99%

Cyanide Reaction with Ninhydrin: Elucidation of Reaction and Interference Mechanisms

Drochioiu

Mangalagiu

Avram³

et al. 2004

ANAL. SCI.

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A new sensitive spectrophotometric method has recently been developed for the trace determination of cyanide with ninhydrin. Cyanide ion was supposed to act as a specific base catalyst. Nevertheless, this paper demonstrates that the reported assay is based on a novel reaction of cyanide with 2,2-dihydroxy-1,3-indanedione, which affords purple or blue colored salts of 2-cyano-1,2,3-trihydroxy-2H indene. Hydrindantin is merely an intermediary of the reaction. The formation of a stable and isolable ninhydrin-cyanide compound has been confirmed by its preparation in crystalline form. Also, it is thoroughly characterized by elemental as well as MS, IR, UV/VIS and 1 H NMR analyses. The Ruhemann's sequence of reactions of cyanide with ninhydrin has been reconsidered and an adequate mechanism of the reaction is proposed. As a consequence, the interference of oxidizers as well as copper, silver and mercury ions with the cyanide determination has been elucidated.

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Determination of traces of cyanide

Cited by 16 publications

References 3 publications

The Analysis of Cyanide and its Breakdown Products in Biological Samples

The Analysis of Cyanide and its Breakdown Products in Biological Samples

Light Absorption Spectrometry

Cyanide Reaction with Ninhydrin: Elucidation of Reaction and Interference Mechanisms

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