Determination of vancomycin-resistant Staphylococcus aureus

Ghasabi, Farzane; Halaji, Mehrdad; Nouri, Samereh

doi:10.4103/2279-042x.200986

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…The option for treatment of MRSA-induced infections and clinical symptoms are limited. Therefore, MRSA has remained a significant threat to human health globally (6)(7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, spa typing allows data comparison between clinical laboratories at the international and na-tional levels (13,14). The prevalence of different spa types among S. aureus isolates varies in different areas around the world (9). Although several studies have reported the spa typing and characterization of MRSA in patients in healthcare settings, this subject has not been investigated in healthy children in the North of Iran.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The spa Typing and Characterization of Nasal Carriage Methicillin-resistant Staphylococcus aureus Isolates From Healthy Children

Rezai¹,

Valadan²,

Ahangarkani³

et al. 2019

J. Pediatr. Rev.

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Background:The Methicillin-resistant Staphylococcus aureus (MRSA) strains cause wide spectrum infections in hospitals and are responsible for the majority of the communityacquired infections. The emergence of community-acquired MRSA in patients without risk factors represents a high risk for public health.Objectives: In this study, we aimed to molecular typing the nasal carriage MRSA strains harbored mecA gene isolated from healthy children living in the North of Iran and also to determine the pattern of vancomycin susceptibility in these isolates. Methods:The MRSA strains were identified using standard microbiological and molecular procedures. The antibiotic susceptibility test was performed according to the clinical and laboratory standards institute. The MRSA strains were characterized by spa typing. Results:In total, 14 different patterns of spa genes were obtained from MRSA isolates in this study, which included t790 (23.07%), t2962 (15.38%), t267 (15.38%), t159 (7.69%) and t701, t094, t1816, t11332, t937, t2135, t180, t160 [1 (3.84%) isolate per each type]. The rate of resistant isolates to cefoxitin, , cefalotin, clindamycin, cefazolin, co-amoxiclav, co-trimoxazole, and cephalexin antibiotics were 69.23%, 100%, 46.15%, 96.15%, 100%, 3.48%, and 100%, respectively. In total, six (23.07%) revealed vancomycin-intermediate resistant phenotype and five (19.23%) isolates revealed vancomycin-resistant S. aureus phenotype. Conclusions:This study showed the different variants of MRSA strains based on molecular typing, among healthy children. Continuous surveillance studies to monitor MRSA should be encouraged to gain a better understanding of the circulating MRSA strains and prevent community spread of this pathogen.

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“…The option for treatment of MRSA-induced infections and clinical symptoms are limited. Therefore, MRSA has remained a significant threat to human health globally (6)(7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%