Determination of Versikine Levels by Enzyme-Linked Immunosorbent Assay (ELISA)

Minns, Alexander Frederick; Santamaria, Salvatore

doi:10.1007/978-1-0716-3589-6_8

Methods in Molecular Biology

2023

DOI: 10.1007/978-1-0716-3589-6_8

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Determination of Versikine Levels by Enzyme-Linked Immunosorbent Assay (ELISA)

Alexander Frederick Minns,

Salvatore Santamaria

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Cited by 2 publications

References 37 publications

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Soluble Proteoglycans and Proteoglycan Fragments as Biomarkers of Pathological Extracellular Matrix Remodeling

Kemberi,

Minns,

Santamaria

2024

Proteoglycan Research

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Proteoglycans and their proteolytic fragments diffuse into biological fluids such as plasma, serum, urine, or synovial fluid, where they can be detected by antibodies or mass‐spectrometry. Neopeptides generated by the proteolysis of proteoglycans are recognized by specific neoepitope antibodies and can act as a proxy for the activity of certain proteases. Proteoglycan and proteoglycan fragments can be potentially used as prognostic, diagnostic, or theragnostic biomarkers for several diseases characterized by dysregulated extracellular matrix remodeling such as osteoarthritis, rheumatoid arthritis, atherosclerosis, thoracic aortic aneurysms, central nervous system disorders, viral infections, and cancer. Here, we review the main mechanisms accounting for the presence of soluble proteoglycans and their fragments in biological fluids, their potential application as diagnostic, prognostic, or theragnostic biomarkers, and highlight challenges and opportunities ahead of their clinical translation.

show abstract

Soluble Proteoglycans and Proteoglycan Fragments as Biomarkers of Pathological Extracellular Matrix Remodeling

Kemberi,

Minns,

Santamaria

2024

Proteoglycan Research

View full text Add to dashboard Cite

show abstract

Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease

de Groot,

Folgado,

Yamamoto

et al. 2025

Matrix Biology

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Determination of Versikine Levels by Enzyme-Linked Immunosorbent Assay (ELISA)

Cited by 2 publications

References 37 publications

Soluble Proteoglycans and Proteoglycan Fragments as Biomarkers of Pathological Extracellular Matrix Remodeling

Soluble Proteoglycans and Proteoglycan Fragments as Biomarkers of Pathological Extracellular Matrix Remodeling

Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease

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