Determination of water quality, toxicity and estrogenic activity in a nearshore marine environment in Rio de Janeiro, Southeastern Brazil

Nascimento, Marília Teresa Lima do; Santos, Ana Dalva de Oliveira; Felix, Louise Cruz; Gomes, Giselle; Sá, Mariana de Oliveira e; Cunha, Danieli Lima da; Vieira, Maria Natividade; Hauser‐Davis, Rachel Ann; Neto, José Antônio Baptista; Bila, Daniele Maia

doi:10.1016/j.ecoenv.2017.11.045

Cited by 41 publications

(17 citation statements)

References 44 publications

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“…In Brazil, pharmaceuticals like hormones and anti-inflammatory agents have already been detected decades ago in raw sewage, treated wastewater, and river water in Rio de Janeiro (Brazilian southern east) [29]. In another study, the estrogenic potential of water sampled from different depths in the nearshore marine environment in Rio de Janeiro, as determined by the yeast estrogen screening assay, indicated that EDCs were adsorbed in the sediments [30]. Moreover, the surface water of a river tributary of a lagoon system in the oceanic region of Rio de Janeiro, which suffers from the discharge of untreated urban sewage, presented extreme ecological risk indexes associated with high concentrations of the steroid 17α-ethynylestradiol and the antibiotic sulfamethoxazole [31].…”

Section: Contamination Of Soil and Water By Pharmaceuticalsmentioning

confidence: 98%

Pharmaceutical Pollution and Disposal of Expired, Unused, and Unwanted Medicines in the Brazilian Context

Freitas

Rádis-Baptista

2021

JoX

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The occurrence of pharmaceuticals in the environment is an everyday recognized concern worldwide, and drugs as environmental contaminants have been detected in water and soil systems, posing risks to humans and wildlife. The presence of drugs in wastewater, groundwater, and even drinking water occurs in several countries, including Brazil, where the pharmaceutical market is expanding over the years. The adverse, harmful effects of pharmaceuticals in the environment range from the spreading of antimicrobial resistance and species survival to the interference with reproduction and increased cancer incidence in humans. Therefore, it is demanding to count on proper legislation to prevent these pollutants from entering the distinct environment compartments. In some developed countries, laws, directives, programs, and initiatives regarding drug disposal reach a mature status. In Brazil, federal laws dealing with drug residues’ management are recent, with flaws that might facilitate non-compliance with drug pollution issues. Besides, pharmacies and drugstores are not obligated to collect unneeded household medicines, while particular State laws aim to ordinate the disposal of drug residues regionally. In this review, we consider the current knowledge about pharmaceutical (drug) pollution, the recommendation and regulations on the disposal of useless medicines in some countries, and in the context of the expanding pharmaceutical market in Brazil. The awareness of emerging contaminants in the environment, besides the joint effort of authorities, consumers, and the general public nationwide, will be required to avoid pharmaceutical/drug pollution and achieve an eco-friendly environment and a sustainable society.

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Section: Contamination Of Soil and Water By Pharmaceuticalsmentioning

confidence: 98%

Pharmaceutical Pollution and Disposal of Expired, Unused, and Unwanted Medicines in the Brazilian Context

Freitas

Rádis-Baptista

2021

JoX

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“…Steroid hormones are important compounds found in the human body that are derived from cholesterol and have characteristics lipid-soluble and normally are grouped into two classes: corticosteroids and sex steroids differenced by bonding receptors and biological functions [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. Hence, different factors (solubilization, motility, transport, metabolism, and complementarity of fit between hormone and receptor) have influence on the activity of steroid hormones.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, estrone, estradiol, estriol, equilenin, equilin and their derivatives are some of species associated with estrogens and, obviously, to steroid hormones [1][2][3][4][5][6][7][8][9]11,13]. Structural studies on these hormones and their quick identifications are very important from medicinal, chemistry, human health, environmental and pharmacological points of view because when these hormones are discharged toward the environmental can affect the systems of all living beings [14,15]. On the other hand, from long time the vibrational spectroscopy was a very useful technique used widely to detect the species related to steroid hormones, as evidenced in the numerous research papers published in the literature [10,12,14,17].…”

Section: Introductionmentioning

confidence: 99%

Structural and vibrational studies of equilenin, equilin and estrone steroids

2019

Biointerface Res Appl Chem

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Three species associated with estrogens have been studied in this work, equilenin, equilin and estrone. Their molecular structures have been theoretically studied in gas phase with the hybrid B3LYP/6-31G* method. NBO, AIM and frontier orbital calculations were computed for the three species at the same level of theory. Higher dipole moment and volume were observed for estrone while equilin presents higher volume than equilenin but lower dipole moment value. Probably, the unsaturated C=C in the B ring of equilin could explain those differences. The differences observed in the properties could be clearly explained by differences in the dihedral angles. The analyses of MK and Mulliken charges evidence the higher variations on the C atoms common to the B, C and D rings in the three species. The mapped MEP surfaces show that both A and B rings of equilenin are different from the other ones because they have aromatic naphthalene core, as was evidenced experimentally. The NBO studies support the higher stability of equilin, in relation to equilenin and estrone while the AIM analyses reveal the higher stability for estrone. The gap values suggest that equilenin is the most reactive species due to its higher global electrophilicity value, in agreement with the higher stability observed for this species while the higher global nucleophilicty values are observed for equilin and estrone. Here, the harmonic force fields, scaled force constants and the complete assignments of 108, 114 and 120 vibration modes for equilenin, equilin and estrone, respectively are reported for first time.

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“…Over recent decades, land disturbance and urbanization in the surrounding area has significantly increased sediment input and all kind of pollution to the bay and had a negative effect on its overall environment (Baptista Neto et al, 2013). Previous studies have pointed out Guanabara Bay as one of the most polluted ecosystems in Brazil (Rebello et al, 1986;Kjerfve et al, 1997;Carreira et al, 2002;Baptista Neto et al, 2006;Covelli et al, 2012;Vilela et al, 2014;Soares-Gomes et al, 2016;Nascimento et al, 2018;Aguiar et al, 2018), with indications that the bay may export pollutants, including heavy metals, to the coastal area (Melo et al, 2014). According to environmental regulations, the local authorities don't permit dredged sediment discharges inside the estuary.…”

Section: Study Areamentioning

confidence: 99%

Geomorphic and Sedimentary Impacts on the Continental Shelf after Accumulated Dredge Disposal from Rio de Janeiro Harbor, Brazil

Dias¹,

Fontana²,

Silva³

et al. 2019

Braz J Geophys

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ABSTRACT.Marine dredging is a sub-aquatic excavation activity executed around the globe for various purposes by many industries. The negative impacts ofdredged material discharge on benthic ecosystems are diverse. Researches on the results of dredging on estuarine geomorphology and its sedimentary regime areusual. Still, the results of dumping dredged material off the coast, in the Brazilian continental shelf, are not easily found in the literature. The present research evaluatedthe geomorphic disturbance resulted from discharging dredged material from Rio de Janeiro Harbor in the inner Rio de Janeiro continental shelf. Grain size analysisof the dredged and dumped sediments was compared to the inner shelf original seabed sediments. The geomorphological impact was evaluated through bathymetricand high resolution seismic and side scan sonar imagery methods. Obtained data revealed significant geomorphologic changes on the offshore bottom caused by theaccumulation of compacted mud from the dredge site underlying the recent soft mud bottom of the harbor area. Besides the morphological sea bottom disturbance,sediment accumulation, and local grain size characteristics exhibited significant change, potentially impacting the surrounding benthic environment.Keywords:compacted mud, Guanabara Bay, grain size.RESUMO.A dragagem marinha é uma atividade de escavação subaquática executada em todo o mundo por muitas indústrias para diferentes fins. Os impactosnegativos do descarte de material dragado nos ecossistemas bentônicos são diversos. Pesquisas sobre os resultados da dragagem na geomorfologia estuarina e o seuregime sedimentar são frequentes. Ainda assim, os resultados do despejo de material dragado ao longo da costa, na plataforma continental brasileira, não são facilmenteencontrados na literatura. A presente pesquisa avaliou o distúrbio geomórfico resultante do descarte de material dragado do Porto do Rio de Janeiro na plataformacontinental interna do Rio de Janeiro. A granulometria dos sedimentos dragados e descartados foi comparada com os sedimentos originais do fundo marinho naplataforma interna. O impacto geomorfológico foi avaliado através de métodos batimétricos, sísmica de alta resolução e imageamento por sonar de varredura lateral.Os dados obtidos revelaram mudanças geomorfológicas significativas no fundo causadas pelo acúmulo de lama compactada do local dragado, subjacente ao fundode lama mole recente da área do porto. Além do distúrbio morfológico do fundo marinho, o acúmulo de sedimentos e as características locais de tamanho de grãoapresentaram mudança significativa, potencialmente impactando o ambiente bentônico circundante.Palavras-chave:lama compactada, Baía de Guanabara, granulometria.

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Determination of water quality, toxicity and estrogenic activity in a nearshore marine environment in Rio de Janeiro, Southeastern Brazil

Cited by 41 publications

References 44 publications

Pharmaceutical Pollution and Disposal of Expired, Unused, and Unwanted Medicines in the Brazilian Context

Pharmaceutical Pollution and Disposal of Expired, Unused, and Unwanted Medicines in the Brazilian Context

Structural and vibrational studies of equilenin, equilin and estrone steroids

Geomorphic and Sedimentary Impacts on the Continental Shelf after Accumulated Dredge Disposal from Rio de Janeiro Harbor, Brazil

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