Determination of withdrawal time, efficacy, and safety test of enrofloxacin in carp (Cyprinus carpio)

Abstract

The use of antibiotic such as enrofloxacin for the treatment of fish diseases needs to be appropriately controlled so that the medicine function effectively and does not cause antibiotic residues above the maximum residues limit (MRL). The study aims to determine the duration of administration, efficacy, and safety of enrofloxacin in carp. The size of the carp used was 10-40 g, with a length of 8-12 cm. The methods used in this study were (a) withdrawal time test, (b) efficacy and safety test, and (c) histopathology analysis. The results of determining enrofloxacin withdrawal time for 0.5 MRL and 1 MRL were two days and eight days, respectively. The survival rates of carp in post-challenge with Aeromonas hydrophila for the positive control and efficacy groups were 86.7% and 88.9%, respectively, and were not significantly different. The results of histopathological observations on the liver, spleen, kidney, and muscle of the carp showed no significant pathological changes between the safety test dose treatment and the control treatment.