Determination of β-blockers in pharmaceutical and human urine by capillary electrophoresis with electrochemiluminescence detection and studies on the pharmacokinetics

Wang, Yuanchao; Wu, Qiong; Cheng, Mengchun; Cai, Cheng

doi:10.1016/j.jchromb.2011.02.032

Cited by 43 publications

(20 citation statements)

References 25 publications

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“…In this assay, if the solution was prepared by liquid with low conductivity (like water), the analyte ion could get into the separation buffer quickly and gradually stack at the leading frontier. With the increase of the analyte ion concentration, the conductivity also increased, causing the deceleration of the leading frontier and more severely stacking of the analyte ions .…”

Section: Resultsmentioning

confidence: 99%

Simultaneous determination of galanthamine and lycorine in Lycoris radiata by a capillary electrophoresis with an electrochemiluminescence method

Wang

Zhu

et al. 2014

J of Separation Science

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A novel capillary electrophoresis with electrochemiluminescence determination method was developed for the determination of two alkaloids based on the electrochemiluminescence signal enhancement effect of the tertiary amine group on tris(2,2'-bipyridyl)ruthenium(II). A linear relationship between the electrochemiluminescence peak area and concentrations of galanthamine and lycorine in the range of 0.07 ∼ 17 μg/mL and 0.07 ∼ 18 μg/mL was obtained and the detection limit was 0.008 and 0.002 μg/mL, respectively. The method is selective, simple, and convenient. It had been successfully applied to the analysis of galanthamine and lycorine in Lycoris radiata samples purchased from a local market.

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Section: Resultsmentioning

confidence: 99%

Simultaneous determination of galanthamine and lycorine in Lycoris radiata by a capillary electrophoresis with an electrochemiluminescence method

Wang

Zhu

et al. 2014

J of Separation Science

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“…Methods reported in references [64,65] used more sensitive detection with simple dilution for metoprolol, and propranolol [17] was analyzed after head space-solid-phase microextraction extraction method, which is comparable with our method, but it is applied for one drug. CE-based methods without FASS used more sensitive detectors and produced higher and/or comparable LODs [53,66].…”

Section: Drugmentioning

confidence: 93%

“…Nominal concentration (ng/ml) (n = 5) Improved determination of beta blocker drugs in human urine | ReseaRch aRticle www.future-science.com CE-based methods (Table 9), three FASS-CE methods [17,64,65] were reported for determination of one beta blocker in urine samples with higher and/or comparable LOD values. Methods reported in references [64,65] used more sensitive detection with simple dilution for metoprolol, and propranolol [17] was analyzed after head space-solid-phase microextraction extraction method, which is comparable with our method, but it is applied for one drug.…”

Section: Drugmentioning

confidence: 99%

Salt-Assisted Lle Combined with Field-Amplified Sample Stacking in Ce for Improved Determination of Beta Blocker Drugs in Human Urine

et al. 2014

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“…Several analytical methods have been reported for the determination of atenolol in human plasma, urine, or pharmaceutical preparations, such as high-performance liquid chromatography [5][6][7][8][9], gas chromatography [10], liquid chromatography [11,12]. Other techniques include voltammetric [13][14][15], electrophoresis [16,17], chemiluminescence [18][19][20], spectrofluorimetric [21], ultraviolet and visible spectrophotometry [22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Direct Spectrophotometric Determination of Atenolol and Timolol Anti-Hypertensive Drugs

El‐Didamony

Moustafa

2017

Int J Pharm Pharm Sci

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Objective: Direct and sensitive spectrophotometric method is described for the quantitative determination of some anti-hypertensive drugs such as atenolol (ATN) and timolol (TIM) in pure forms as well as in their dosage forms. Methods:The proposed method is based on the redox reaction between the selected drugs and KMnO4 in alkaline medium. The method involves treating the aqueous solution of the selected drugs with KMnO4 in alkaline medium and measuring the bluish-green product at 610 nm. The different experimental parameters affecting the development and stability of the color were carefully studied and optimized. Results:The fixed-time method is adopted for constructing the calibration curves, which were found to be linear over the concentration ranges of 2.0-14 µg/ml and 2.0-28 µg/ml for ATN and TIM, respectively. The determination of the studied drugs by initial rate, variable time and rate constant method was workable with the calibration equations obtained but the fixed time method has been found to be more applicable. Conclusion:The applicability of the proposed method was demonstrated by the determination of the selected drugs in both pure and in commercial dosage forms and has met the validation requirements.

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Determination of β-blockers in pharmaceutical and human urine by capillary electrophoresis with electrochemiluminescence detection and studies on the pharmacokinetics

Cited by 43 publications

References 25 publications

Simultaneous determination of galanthamine and lycorine in Lycoris radiata by a capillary electrophoresis with an electrochemiluminescence method

Simultaneous determination of galanthamine and lycorine in Lycoris radiata by a capillary electrophoresis with an electrochemiluminescence method

Salt-Assisted Lle Combined with Field-Amplified Sample Stacking in Ce for Improved Determination of Beta Blocker Drugs in Human Urine

Direct Spectrophotometric Determination of Atenolol and Timolol Anti-Hypertensive Drugs

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