Determinaton of sildenafil citrate and related substances in the commercial products and tablet dosage form using HPLC

Phytochemical Techniques in Complex Botanicals. The XXI Century Analytical Challenge

“…NMR has been proposed as the possible tool in natural products fingerprint and its use reported on foods and medicinal drugs [17][18][19], including the analysis of adulteration or food supplements spiked with synthetic products, when a single simple HPTLC plate can be sufficient [17][18][19][20][21][22][23]. The main problem to face is that also using a spectrometer of high resolution, the possibility of peaks overlapping remains very high.…”

Phytochemical Techniques in Complex Botanicals. The XXI Century Analytical Challenge

“…NMR has been proposed as the possible tool in natural products fingerprint and its use reported on foods and medicinal drugs [17][18][19], including the analysis of adulteration or food supplements spiked with synthetic products, when a single simple HPTLC plate can be sufficient [17][18][19][20][21][22][23]. The main problem to face is that also using a spectrometer of high resolution, the possibility of peaks overlapping remains very high.…”

Separation and Determination of Synthetic Impurities of Sildenafil (Viagra) by Reversed-Phase High-Performance Liquid Chromatography

“…14 A reversed-phase HPLC method for the determination of its related substances in commercial formulations and tablets was reported. 15 However, it did not attempt to separate 1-methyl-4-nitro-3-propylpyrazole-5-carboxylic acid (MNP), which is most likely to be present as an impurity in the final products of SLD. In this paper we describe a simple and rapid reversed-phase HPLC method for the separation and determination of small amounts of all probable impurities of SLD, not only for quality assurance, but also to monitor the procedures followed during its synthesis.…”