Determining biosensing modes in SH-SAW device using 3D finite element analysis

Brookes, Jennifer C.; Bufacchi, Rory John; Kondoh, Jun; Duffy, Dorothy M.; McKendry, Rachel A.

doi:10.1016/j.snb.2016.03.103

Cited by 16 publications

(10 citation statements)

References 21 publications

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“…Other types of visuotactile and audiotactile integration have also been shown to increase in magnitude with proximity the body [87] . Data reproduced, with permission, from 9 , 25 , 88 . …”

Section: More Than An ‘In-or-out’ Bubblementioning

confidence: 99%

An Action Field Theory of Peripersonal Space

Bufacchi

Iannetti

2018

Trends in Cognitive Sciences

170

142

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Predominant conceptual frameworks often describe peripersonal space (PPS) as a single, distance-based, in-or-out zone within which stimuli elicit enhanced neural and behavioural responses. Here we argue that this intuitive framework is contradicted by neurophysiological and behavioural data. First, PPS-related measures are not binary, but graded with proximity. Second, they are strongly influenced by factors other than proximity, such as walking, tool use, stimulus valence, and social cues. Third, many different PPS-related responses exist, and each can be used to describe a different space. Here, we reconceptualise PPS as a set of graded fields describing behavioural relevance of actions aiming to create or avoid contact between objects and the body. This reconceptualisation incorporates PPS into mainstream theories of action selection and behaviour.

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“…Other types of visuotactile and audiotactile integration have also been shown to increase in magnitude with proximity the body [87] . Data reproduced, with permission, from 9 , 25 , 88 . …”

Section: More Than An ‘In-or-out’ Bubblementioning

confidence: 99%

An Action Field Theory of Peripersonal Space

Bufacchi

Iannetti

2018

Trends in Cognitive Sciences

170

142

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“…In the literature, various materials such as ZnO, gold [25], titanium [31], and platinum [32] have been proposed as guiding and sensing layers where the requisite is mainly determined by the acoustic and mechanical properties such as shear velocity, Young modulus and density. To obtain an efficient guiding layer, the material should have a lower shear wave velocity compared to the piezoelectric layer and the substrate.…”

Section: Resultsmentioning

confidence: 99%

“…Such applications using surface modes require an array of pillar or a layer of thin film on the top of surface acting as a guiding and sensing layer since Rayleigh SAW will induce a radiation into the fluid in the form of a longitudinal wave [23]. The integration of such a thin layer made from various materials such as SiO2 [24], Au [25] and ZnO [26] on a bulk piezoelectric substrate would confine the Love’s wave energy onto the surface; thus, the sensitivity could be increased directly under surface perturbations. Nevertheless, the effectiveness of such a sensing layer on GaN heterostructure has never been investigated in the literature, especially in the case of Sezawa mode with the presence of liquid required for the development of biosensing platform.…”

Section: Introductionmentioning

confidence: 99%

A Theoretical Study of Surface Mode Propagation with a Guiding Layer of GaN/Sapphire Hetero-Structure in Liquid Medium

et al. 2018

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Gallium Nitride (GaN) is considered as the second most popular semiconductor material in industry after silicon. This is due to its wide applications encompassing Light Emitting Diode (LED) and power electronics. In addition, its piezoelectric properties are fascinating to be explored as electromechanical material for the development of diverse microelectromechanical systems (MEMS) application. In this article, we conducted a theoretical study concerning surface mode propagation, especially Rayleigh and Sezawa mode in the layered GaN/sapphire structure with the presence of various guiding layers. It is demonstrated that the increase in thickness of guiding layer will decrease the phase velocities of surface mode depending on the material properties of the layer. In addition, the Q-factor value indicating the resonance properties of surface mode appeared to be affected with the presence of fluid domain, particularly in the Rayleigh mode. Meanwhile, the peak for Sezawa mode shows the highest Q factor and is not altered by the presence of fluid. Based on these theoretical results using the finite element method, it could contribute to the development of a GaN-based device to generate surface acoustic wave, especially in Sezawa mode which could be useful in acoustophoresis, lab on-chip and microfluidics applications.

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“…We show that the platform technology can also be tailored to detect p24, via an immuno-sandwich complex. Further work to understand the fundamental origin of the SAW signal is underway 51 . These developments aim to enable detection of low level of p24 associated with early infections, where a person may unknowingly be 26 times more infectious than during later asymptomatic infection 52 .…”

Section: Discussionmentioning

confidence: 99%

Towards an ultra-rapid smartphone- connected test for infectious diseases

Turbé

Gray

Lawson

et al. 2017

Sci Rep

Self Cite

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The development is reported of an ultra-rapid, point-of-care diagnostic device which harnesses surface acoustic wave (SAW) biochips, to detect HIV in a finger prick of blood within 10 seconds (samplein-result-out). The disposable quartz biochip, based on microelectronic components found in every consumer smartphone, is extremely fast because no complex labelling, amplification or wash steps are needed. A pocket-sized control box reads out the SAW signal and displays results electronically. High analytical sensitivity and specificity are found with model and real patient blood samples. The findings presented here open up the potential of consumer electronics to cut lengthy test waiting times, giving patients on the spot access to potentially life-saving treatment and supporting more timely public health interventions to prevent disease transmission.Ebola and Zika viruses offer a stark reminder that infectious diseases rank among the gravest threats to human health, and can spread rapidly and unpredictably. New infections will continue to emerge each year, and old enemies re-emerge, increasingly with acquired-drug resistance (e.g. gonorrhoea and HIV). Rapid diagnosis plays a crucial role in any outbreak situation, empowering patients to gain faster access to potentially life-saving treatment, and informing prevention strategies to protect the wider public. However, routine diagnostic tests based on enzyme linked immunosorbent assays (ELISAs) and polymerase chain reaction (PCR) are confined to centralized laboratories often requiring large, sophisticated, costly instrumentation and highly trained staff. Inherent delays occur between taking samples, conveying them to the laboratory, waiting for results to come back and subsequent follow up appointments 1-3 . This means that a patient often has to make multiple visits to a clinic in order to receive treatment, potentially over long distances. This delays prescribing of treatment with increased risk of suffering, mortality, and also incorrect prescription of antimicrobials.Recent policy drivers aim to widen access to testing using so called 'rapid' point-of-care tests (POCT) but the performance and implementation of these tests still remain a challenge 4 . The most common tests based on lateral flow technology are still relatively slow, requiring a 10-20 minute waiting time for results 5 . This exceeds a typical doctor's appointment (8-10 mins in the UK 6 ) necessitating changes to patient pathways within a clinic with additional on-costs and staffing implications. It is also notoriously difficult to interpret a faint lateral flow test line by eye, particularly for non-experts (e.g. self-testers) 1 . Those tests that are currently available are insensitive to recent (acute) infections 7 and lack the ability to automatically capture test results electronically, risking an incorrect reading, missed opportunities to link patients to care pathways and potential data loss for public health (e.g. during an Ebola outbreak) 8 . Alternatively, uneccesary treatment may be initi...

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Determining biosensing modes in SH-SAW device using 3D finite element analysis

Cited by 16 publications

References 21 publications

An Action Field Theory of Peripersonal Space

An Action Field Theory of Peripersonal Space

A Theoretical Study of Surface Mode Propagation with a Guiding Layer of GaN/Sapphire Hetero-Structure in Liquid Medium

Towards an ultra-rapid smartphone- connected test for infectious diseases

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